Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033148417> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3033148417 endingPage "2745" @default.
- W3033148417 startingPage "2735" @default.
- W3033148417 abstract "Parameterization of dissolution profiles for subsequent use in in silico modeling and simulation is a crucial element for the success of extrapolating in vitro to in vivo release from solid oral dosage forms. The z-factor dissolution model is an option that can be utilized in commercial software such as GastroPlus™ to simulate the release from solid oral dosage forms. However, several aspects that can confound particle dissolution, such as disintegration and coning, are currently not taken into consideration in this model. To promote a more comprehensive use of the z-factor dissolution model, we discuss the scope of the model in its current modus operandi, highlight problems associated with the current approach and present potential solutions. Taking into account disintegration of dosage forms together with a calculation of the theoretical mass available for dissolution allows for a more realistic z-factor estimate that considers the dissolution process in terms of its two core components, dosage form disintegration and particle dissolution, independently. It is shown that separating these two elements allows for more flexible evaluation and use of the z-factor approach in modeling softwares, as both elements can then be scaled independently to describe the behavior in a range of simulated physiological environments." @default.
- W3033148417 created "2020-06-12" @default.
- W3033148417 creator A5033876964 @default.
- W3033148417 creator A5076946026 @default.
- W3033148417 date "2020-09-01" @default.
- W3033148417 modified "2023-10-16" @default.
- W3033148417 title "Suitability of the z-Factor for Dissolution Simulation of Solid Oral Dosage Forms: Potential Pitfalls and Refinements" @default.
- W3033148417 cites W1576144270 @default.
- W3033148417 cites W2017937842 @default.
- W3033148417 cites W2019096448 @default.
- W3033148417 cites W2030951340 @default.
- W3033148417 cites W2039634394 @default.
- W3033148417 cites W2049925761 @default.
- W3033148417 cites W2060318369 @default.
- W3033148417 cites W2345670636 @default.
- W3033148417 cites W2463511221 @default.
- W3033148417 cites W2505398905 @default.
- W3033148417 cites W2514383788 @default.
- W3033148417 cites W252369352 @default.
- W3033148417 cites W2592176131 @default.
- W3033148417 cites W2726970446 @default.
- W3033148417 cites W2967653042 @default.
- W3033148417 cites W2991768391 @default.
- W3033148417 doi "https://doi.org/10.1016/j.xphs.2020.05.019" @default.
- W3033148417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32497594" @default.
- W3033148417 hasPublicationYear "2020" @default.
- W3033148417 type Work @default.
- W3033148417 sameAs 3033148417 @default.
- W3033148417 citedByCount "13" @default.
- W3033148417 countsByYear W30331484172020 @default.
- W3033148417 countsByYear W30331484172021 @default.
- W3033148417 countsByYear W30331484172022 @default.
- W3033148417 countsByYear W30331484172023 @default.
- W3033148417 crossrefType "journal-article" @default.
- W3033148417 hasAuthorship W3033148417A5033876964 @default.
- W3033148417 hasAuthorship W3033148417A5076946026 @default.
- W3033148417 hasConcept C111919701 @default.
- W3033148417 hasConcept C127413603 @default.
- W3033148417 hasConcept C14029885 @default.
- W3033148417 hasConcept C147789679 @default.
- W3033148417 hasConcept C183696295 @default.
- W3033148417 hasConcept C185592680 @default.
- W3033148417 hasConcept C186060115 @default.
- W3033148417 hasConcept C192562407 @default.
- W3033148417 hasConcept C199360897 @default.
- W3033148417 hasConcept C21880701 @default.
- W3033148417 hasConcept C2778012447 @default.
- W3033148417 hasConcept C2781430271 @default.
- W3033148417 hasConcept C41008148 @default.
- W3033148417 hasConcept C43617362 @default.
- W3033148417 hasConcept C77281830 @default.
- W3033148417 hasConcept C86803240 @default.
- W3033148417 hasConcept C88380143 @default.
- W3033148417 hasConcept C98045186 @default.
- W3033148417 hasConceptScore W3033148417C111919701 @default.
- W3033148417 hasConceptScore W3033148417C127413603 @default.
- W3033148417 hasConceptScore W3033148417C14029885 @default.
- W3033148417 hasConceptScore W3033148417C147789679 @default.
- W3033148417 hasConceptScore W3033148417C183696295 @default.
- W3033148417 hasConceptScore W3033148417C185592680 @default.
- W3033148417 hasConceptScore W3033148417C186060115 @default.
- W3033148417 hasConceptScore W3033148417C192562407 @default.
- W3033148417 hasConceptScore W3033148417C199360897 @default.
- W3033148417 hasConceptScore W3033148417C21880701 @default.
- W3033148417 hasConceptScore W3033148417C2778012447 @default.
- W3033148417 hasConceptScore W3033148417C2781430271 @default.
- W3033148417 hasConceptScore W3033148417C41008148 @default.
- W3033148417 hasConceptScore W3033148417C43617362 @default.
- W3033148417 hasConceptScore W3033148417C77281830 @default.
- W3033148417 hasConceptScore W3033148417C86803240 @default.
- W3033148417 hasConceptScore W3033148417C88380143 @default.
- W3033148417 hasConceptScore W3033148417C98045186 @default.
- W3033148417 hasIssue "9" @default.
- W3033148417 hasLocation W30331484171 @default.
- W3033148417 hasOpenAccess W3033148417 @default.
- W3033148417 hasPrimaryLocation W30331484171 @default.
- W3033148417 hasRelatedWork W1971957888 @default.
- W3033148417 hasRelatedWork W2014152768 @default.
- W3033148417 hasRelatedWork W2035843972 @default.
- W3033148417 hasRelatedWork W2092267554 @default.
- W3033148417 hasRelatedWork W2104438858 @default.
- W3033148417 hasRelatedWork W2323797364 @default.
- W3033148417 hasRelatedWork W2392659217 @default.
- W3033148417 hasRelatedWork W2394297123 @default.
- W3033148417 hasRelatedWork W2414870174 @default.
- W3033148417 hasRelatedWork W4211011431 @default.
- W3033148417 hasVolume "109" @default.
- W3033148417 isParatext "false" @default.
- W3033148417 isRetracted "false" @default.
- W3033148417 magId "3033148417" @default.
- W3033148417 workType "article" @default.