FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033149024> ?p ?o ?g. }

• W3033149024 endingPage "1417" @default.
• W3033149024 startingPage "1417" @default.
• W3033149024 abstract "Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the phosphoinositide composition of the retina is limited. Here, we report a characterization of the phosphoinositide profile of the mouse retina and an analysis of the subcellular localization of major phosphorylated phosphoinositide forms in light-sensitive photoreceptor neurons. Using chromatography of deacylated phosphatidylinositol headgroups, we established PI(4,5)P2 and PI(4)P as two major phosphorylated phosphoinositides in the retina. Using high-resolution mass spectrometry, we revealed 18:0/20:4 and 16:0/20:4 as major fatty-acyl chains of retinal phosphoinositides. Finally, analysis of fluorescent phosphoinositide sensors in rod photoreceptors demonstrated distinct subcellular distribution patterns of major phosphoinositides. The PI(4,5)P2 reporter was enriched in the inner segments and synapses, but was barely detected in the light-sensitive outer segments. The PI(4)P reporter was mostly found in the outer and inner segments and the areas around nuclei, but to a lesser degree in the synaptic region. These findings provide support for future mechanistic studies defining the biological significance of major mono- (PI(4)P) and bisphosphate (PI(4,5)P2) phosphatidylinositols in photoreceptor biology and retinal health." @default.
• W3033149024 created "2020-06-12" @default.
• W3033149024 creator A5000266633 @default.
• W3033149024 creator A5005562867 @default.
• W3033149024 creator A5017312602 @default.
• W3033149024 creator A5020344994 @default.
• W3033149024 creator A5044202408 @default.
• W3033149024 creator A5060418560 @default.
• W3033149024 date "2020-06-07" @default.
• W3033149024 modified "2023-10-14" @default.
• W3033149024 title "Phosphoinositide Profile of the Mouse Retina" @default.
• W3033149024 cites W1503104403 @default.
• W3033149024 cites W1555546746 @default.
• W3033149024 cites W1556038076 @default.
• W3033149024 cites W1595357503 @default.
• W3033149024 cites W1964573575 @default.
• W3033149024 cites W1967919846 @default.
• W3033149024 cites W1968093517 @default.
• W3033149024 cites W1968800607 @default.
• W3033149024 cites W1969429227 @default.
• W3033149024 cites W1978790799 @default.
• W3033149024 cites W1982074703 @default.
• W3033149024 cites W2000101474 @default.
• W3033149024 cites W2003052331 @default.
• W3033149024 cites W2003120338 @default.
• W3033149024 cites W2003709444 @default.
• W3033149024 cites W2009432227 @default.
• W3033149024 cites W2011919807 @default.
• W3033149024 cites W2019700277 @default.
• W3033149024 cites W2034224423 @default.
• W3033149024 cites W2044337730 @default.
• W3033149024 cites W2045859605 @default.
• W3033149024 cites W2052454481 @default.
• W3033149024 cites W2052785197 @default.
• W3033149024 cites W2060526968 @default.
• W3033149024 cites W2070360107 @default.
• W3033149024 cites W2078832413 @default.
• W3033149024 cites W2085035388 @default.
• W3033149024 cites W2086493498 @default.
• W3033149024 cites W2147621341 @default.
• W3033149024 cites W2161947280 @default.
• W3033149024 cites W2162228329 @default.
• W3033149024 cites W2166881406 @default.
• W3033149024 cites W2168636256 @default.
• W3033149024 cites W2168900277 @default.
• W3033149024 cites W2276630789 @default.
• W3033149024 cites W2311826957 @default.
• W3033149024 cites W2409187892 @default.
• W3033149024 cites W2595964111 @default.
• W3033149024 cites W2596080911 @default.
• W3033149024 cites W2794919915 @default.
• W3033149024 cites W2801291098 @default.
• W3033149024 cites W2807488219 @default.
• W3033149024 cites W2884972603 @default.
• W3033149024 cites W2900124590 @default.
• W3033149024 cites W2906361666 @default.
• W3033149024 cites W2955716479 @default.
• W3033149024 cites W2966581065 @default.
• W3033149024 cites W2981565897 @default.
• W3033149024 cites W2988174937 @default.
• W3033149024 cites W3001602420 @default.
• W3033149024 cites W3008378263 @default.
• W3033149024 cites W3014749058 @default.
• W3033149024 cites W3117961330 @default.
• W3033149024 doi "https://doi.org/10.3390/cells9061417" @default.
• W3033149024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7349851" @default.
• W3033149024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32517352" @default.
• W3033149024 hasPublicationYear "2020" @default.
• W3033149024 type Work @default.
• W3033149024 sameAs 3033149024 @default.
• W3033149024 citedByCount "15" @default.
• W3033149024 countsByYear W30331490242020 @default.
• W3033149024 countsByYear W30331490242021 @default.
• W3033149024 countsByYear W30331490242022 @default.
• W3033149024 countsByYear W30331490242023 @default.
• W3033149024 crossrefType "journal-article" @default.
• W3033149024 hasAuthorship W3033149024A5000266633 @default.
• W3033149024 hasAuthorship W3033149024A5005562867 @default.
• W3033149024 hasAuthorship W3033149024A5017312602 @default.
• W3033149024 hasAuthorship W3033149024A5020344994 @default.
• W3033149024 hasAuthorship W3033149024A5044202408 @default.
• W3033149024 hasAuthorship W3033149024A5060418560 @default.
• W3033149024 hasBestOaLocation W30331490241 @default.
• W3033149024 hasConcept C11960822 @default.
• W3033149024 hasConcept C169760540 @default.
• W3033149024 hasConcept C190062978 @default.
• W3033149024 hasConcept C2776879804 @default.
• W3033149024 hasConcept C2777093970 @default.
• W3033149024 hasConcept C2780610907 @default.
• W3033149024 hasConcept C2780827179 @default.
• W3033149024 hasConcept C55493867 @default.
• W3033149024 hasConcept C86803240 @default.
• W3033149024 hasConcept C95444343 @default.
• W3033149024 hasConceptScore W3033149024C11960822 @default.
• W3033149024 hasConceptScore W3033149024C169760540 @default.
• W3033149024 hasConceptScore W3033149024C190062978 @default.
• W3033149024 hasConceptScore W3033149024C2776879804 @default.
• W3033149024 hasConceptScore W3033149024C2777093970 @default.

• next