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- W3033161014 abstract "Sodium-glucose co-transporter 2 Inhibitors (SGLT2i) were initially developed as therapeutic options for patients with type 2 diabetes mellitus (T2DM). Recently, randomized clinical trials have investigated their effects in cardiorenal protection through major adverse cardiovascular event reduction and reductions in diabetic nephropathy. While multiple mechanisms are proposed for this protection, microvascular protection is the primary component of their efficacy. While not primarily emphasized in clinical trials, evidence in other studies suggests that SGLT2i may confer retinoprotective effects via some of the same mechanisms in the aforementioned cardiorenal trials. Diabetic patients are susceptible to vision loss with chronic hyperglycemia promoting inflammation, edema, and retinal pathological changes. Targeting these pathways via SGLT2i may represent opportunities for providers to decrease retinopathy in high-risk T2DM patients, reduce disease progression, and lower drug burden in diabetic retinopathy patients. Further comprehensive clinical trials investigating these associations are needed to establish the potential retinoprotective effects of SGLT2i." @default.
- W3033161014 created "2020-06-12" @default.
- W3033161014 creator A5033120729 @default.
- W3033161014 creator A5036425463 @default.
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- W3033161014 creator A5065652220 @default.
- W3033161014 creator A5083786375 @default.
- W3033161014 creator A5091860810 @default.
- W3033161014 date "2020-05-18" @default.
- W3033161014 modified "2023-09-26" @default.
- W3033161014 title "Sodium-glucose co-transporter 2 inhibitors and diabetic retinopathy: insights into preservation of sight and looking beyond" @default.
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