FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033205657> ?p ?o ?g. }

• W3033205657 endingPage "9562" @default.
• W3033205657 startingPage "9547" @default.
• W3033205657 abstract "Circulating plasma TRAIL levels are suppressed in patients with cardiovascular and diabetic diseases. To identify novel targets in vascular metabolic diseases, genome-wide transcriptome of aortic tissue from Trail-/- versus Trail+/+ mice were interrogated. We found 861 genes differentially expressed with TRAIL deletion. Gene enrichment analyses showed many of these genes were related to inflammation, cell-to-cell cytoskeletal interactions, and transcriptional modulation. We identified vascular protective and pathological gene clusters, with Ifi205 as the most significantly reduced vascular protective gene, whereas Glut1, the most significantly increased pathological gene with TRAIL deletion. We hypothesized that therapeutic targets could be devised from such integrated analysis and validated our findings from vascular tissues of diabetic mice. From the differentially expressed gene targets, enriched transcription factor (TF) and microRNA binding motifs were identified. The top two TFs were Elk1 and Sp1, with enrichment to eight gene targets common to both. miR-520d-3p and miR-377-3p were the top enriched microRNAs with TRAIL deletion; with four overlapping genes enriched for both microRNAs. Our findings offer an alternate in silico approach for therapeutic target identification and present a deeper understanding of gene signatures and pathways altered with TRAIL suppression in the vasculature." @default.
• W3033205657 created "2020-06-12" @default.
• W3033205657 creator A5001887990 @default.
• W3033205657 creator A5012694789 @default.
• W3033205657 creator A5017104699 @default.
• W3033205657 creator A5025820627 @default.
• W3033205657 creator A5031619803 @default.
• W3033205657 creator A5042774923 @default.
• W3033205657 creator A5044572475 @default.
• W3033205657 creator A5059973362 @default.
• W3033205657 creator A5066889643 @default.
• W3033205657 creator A5079414138 @default.
• W3033205657 date "2020-06-05" @default.
• W3033205657 modified "2023-10-05" @default.
• W3033205657 title "Vascular transcriptome landscape of<i>Trail</i>^−/−mice: Implications and therapeutic strategies for diabetic vascular disease" @default.
• W3033205657 cites W135611249 @default.
• W3033205657 cites W1966693400 @default.
• W3033205657 cites W1977668440 @default.
• W3033205657 cites W1980033411 @default.
• W3033205657 cites W1983268059 @default.
• W3033205657 cites W1986222655 @default.
• W3033205657 cites W1987847260 @default.
• W3033205657 cites W1997342995 @default.
• W3033205657 cites W2006243734 @default.
• W3033205657 cites W2010000535 @default.
• W3033205657 cites W2010913093 @default.
• W3033205657 cites W2011467994 @default.
• W3033205657 cites W2016556817 @default.
• W3033205657 cites W2017417901 @default.
• W3033205657 cites W2017513433 @default.
• W3033205657 cites W2018496442 @default.
• W3033205657 cites W2019335338 @default.
• W3033205657 cites W2021323060 @default.
• W3033205657 cites W2029916147 @default.
• W3033205657 cites W2035618305 @default.
• W3033205657 cites W2036793133 @default.
• W3033205657 cites W2037439427 @default.
• W3033205657 cites W2048795636 @default.
• W3033205657 cites W2051033989 @default.
• W3033205657 cites W2053794983 @default.
• W3033205657 cites W2058275368 @default.
• W3033205657 cites W2058532824 @default.
• W3033205657 cites W2059215745 @default.
• W3033205657 cites W2065218073 @default.
• W3033205657 cites W2070502512 @default.
• W3033205657 cites W2077767552 @default.
• W3033205657 cites W2081808302 @default.
• W3033205657 cites W2082690239 @default.
• W3033205657 cites W2084346552 @default.
• W3033205657 cites W2086969742 @default.
• W3033205657 cites W2094869832 @default.
• W3033205657 cites W2097186487 @default.
• W3033205657 cites W2102844162 @default.
• W3033205657 cites W2105069636 @default.
• W3033205657 cites W2105902283 @default.
• W3033205657 cites W2109972242 @default.
• W3033205657 cites W2110149048 @default.
• W3033205657 cites W2115122333 @default.
• W3033205657 cites W2121271900 @default.
• W3033205657 cites W2128383347 @default.
• W3033205657 cites W2130410032 @default.
• W3033205657 cites W2130597092 @default.
• W3033205657 cites W2133465414 @default.
• W3033205657 cites W2134195812 @default.
• W3033205657 cites W2138523965 @default.
• W3033205657 cites W2142690926 @default.
• W3033205657 cites W2142790993 @default.
• W3033205657 cites W2144500845 @default.
• W3033205657 cites W2145998835 @default.
• W3033205657 cites W2151356556 @default.
• W3033205657 cites W2151473045 @default.
• W3033205657 cites W2151746400 @default.
• W3033205657 cites W2153417050 @default.
• W3033205657 cites W2155794059 @default.
• W3033205657 cites W2156475012 @default.
• W3033205657 cites W2156914280 @default.
• W3033205657 cites W2158217645 @default.
• W3033205657 cites W2159030877 @default.
• W3033205657 cites W2159400209 @default.
• W3033205657 cites W2161121464 @default.
• W3033205657 cites W2161481757 @default.
• W3033205657 cites W2165921560 @default.
• W3033205657 cites W2166037639 @default.
• W3033205657 cites W2177453198 @default.
• W3033205657 cites W2180097643 @default.
• W3033205657 cites W2271027602 @default.
• W3033205657 cites W2279531754 @default.
• W3033205657 cites W2288842131 @default.
• W3033205657 cites W2295692848 @default.
• W3033205657 cites W2343450311 @default.
• W3033205657 cites W2409431235 @default.
• W3033205657 cites W2410206769 @default.
• W3033205657 cites W2416550997 @default.
• W3033205657 cites W2472818137 @default.
• W3033205657 cites W2554396333 @default.
• W3033205657 cites W2599317872 @default.
• W3033205657 cites W2613965503 @default.
• W3033205657 cites W2735806443 @default.

• next