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• W3033221405 abstract "Abstract While microbiological resistance to vancomycin in Staphylococcus aureus is rare, clinical vancomycin treatment failures are common, and methicillin-resistant S. aureus (MRSA) strains isolated from patients after prolonged vancomycin treatment failure remain susceptible. Adaptive laboratory evolution was utilized to uncover mutational mechanisms associated with MRSA vancomycin resistance in a bacteriological medium used in clinical susceptibility testing and a physiological medium. Sequencing of resistant clones revealed shared and media-specific mutational outcomes, with an overlap in cell wall regulons ( walKRyycHI, vraSRT ). Evolved strains displayed similar genetic and phenotypic traits to resistant clinical isolates. Importantly, resistant phenotypes that developed in physiological media did not translate into resistance in bacteriological media. Further, a bacteriological media-specific mechanism for vancomycin resistance enabled by a mutated mprF was confirmed. This study bridges the gap of understanding between clinical and microbiological vancomycin resistance in S. aureus and expands the number of allelic variants that result in vancomycin resistance phenotypes." @default.
• W3033221405 created "2020-06-12" @default.
• W3033221405 creator A5002819499 @default.
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• W3033221405 date "2020-06-07" @default.
• W3033221405 modified "2023-09-27" @default.
• W3033221405 title "Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus" @default.
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• W3033221405 doi "https://doi.org/10.1101/2020.06.07.138933" @default.
• W3033221405 hasPublicationYear "2020" @default.
• W3033221405 type Work @default.
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