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- W3033236495 abstract "Summary The emergence and rapid spread of multidrug‐resistant bacteria has induced intense research for novel therapeutic approaches. In this study, the Acinetobacter baumannii bacteriophage D2 (vB_AbaP_D2) was isolated, characterized and sequenced. The endolysin of bacteriophage D2, namely Abtn‐4, contains an amphipathic helix and was found to have activity against multidrug‐resistant Gram‐negative strains. By more than 3 log units, A. baumannii were killed by Abtn‐4 (5 µM) in 2 h. In absence of outer membrane permeabilizers, Abtn‐4 exhibited broad antimicrobial activity against several Gram‐positive and Gram‐negative bacteria, such as Staphylococcus aureus , Pseudomonas aeruginosa , Klebsiella pneumonia , Enterococcus and Salmonella . Furthermore, Abtn‐4 had the ability to reduce biofilm formation. Interestingly, Abtn‐4 showed antimicrobial activity against phage‐resistant bacterial mutants. Based on these results, endolysin Abtn‐4 may be a promising candidate therapeutic agent for multidrug‐resistant bacterial infections." @default.
- W3033236495 created "2020-06-12" @default.
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- W3033236495 date "2020-06-10" @default.
- W3033236495 modified "2023-10-11" @default.
- W3033236495 title "The endolysin of the <i>Acinetobacter baumannii</i> phage vB_AbaP_D2 shows broad antibacterial activity" @default.
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- W3033236495 doi "https://doi.org/10.1111/1751-7915.13594" @default.
- W3033236495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7936296" @default.
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- W3033236495 hasPublicationYear "2020" @default.
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