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- W3033253453 abstract "The aim of this thesis isto investigate the adoption of PGx and the integration of genotype guideddosing in the workflow of physicians and pharmacists in primary care. Thisthesis is divided into five parts. The first part provides an overview ofanswers to frequently asked questions by clinicians related to theimplementation of PGx. The second part of this covers investigates whethergenotype guided dosing in primary care is feasible in a pilot studywhere 200 patients with an incident prescription for a subset of 10 drugs andhistorical use are genotyped in a panel based approach for 8 pharmacogenes andreceived genotype guided dosing based on recommendations of the DPWG guidelinesand covers an assessment of the clinical impact of PGx in primary care in theNetherlands is provided to predict how many patients that start with a drugcurrently described in the guidelines of the DPWG require an optimization oftherapy. Part III covers the harmonization of PGx-test interpretation andtherapeutic recommendations. Part IV investigates the knowledge, experience andattitudes towards PGx among (future) healthcare professionals. The thesis isconcluded with a general discussion." @default.
- W3033253453 created "2020-06-12" @default.
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- W3033253453 date "2018-11-14" @default.
- W3033253453 modified "2023-09-26" @default.
- W3033253453 title "Improving acceptance of pharmacogenetic testing in patient care" @default.
- W3033253453 hasPublicationYear "2018" @default.
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