FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033254893> ?p ?o ?g. }

• W3033254893 abstract "Abstract Inflammation is the primary pathological feature of neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s disease. Proinflammatory molecules (e.g. S100A9) play important roles during progression of the diseases by regulating behavior and fate of multiple cell types in the nervous system ( 1 ). Our earlier studies reveal that S100A9 is toxic to neurons, and its interaction with A β peptides leads to the formation of large non-toxic amyloidogenic aggregates, suggesting a protective role of A β amyloids ( 2 ). We herein, demonstrate that S100A9 interacts with neural stem cells (NSCs) and causes NSC differentiation. In the brain of transgenic AD mouse models, we found large quantities of proinflammatory S100A9, which colocalizes with the differentiated NSCs. NSC sphere formation, which is a representative character of NSC stemness, is also substantially inhibited by S100A9. These results suggest that S100A9 is a representative marker for the inflammatory conditions in AD, and it promotes NSC differentiation. Intriguingly, in contrast to the death of both stem and differentiated NSCs caused by high S100A9 doses, S100A9 at a moderate concentration is toxic only to the early differentiated NSCs (i.e. progenitor cells and immature neurons), but not the stem cells. We therefore postulate that at the early stage of AD, expression of S100A9 leads to NSC differentiation, which remedies the neuron damages. The application drugs, which help maintain NSC stemness (e.g. PDGF), may help overcome the acute inflammatory conditions and improve the efficacy of NSC transplantation therapy." @default.
• W3033254893 created "2020-06-12" @default.
• W3033254893 creator A5006715236 @default.
• W3033254893 creator A5008654532 @default.
• W3033254893 creator A5009374812 @default.
• W3033254893 creator A5026144539 @default.
• W3033254893 creator A5026954909 @default.
• W3033254893 creator A5059276823 @default.
• W3033254893 creator A5060453448 @default.
• W3033254893 creator A5077069068 @default.
• W3033254893 creator A5080646722 @default.
• W3033254893 date "2020-06-07" @default.
• W3033254893 modified "2023-09-23" @default.
• W3033254893 title "Proinflammatory S100A9 Regulate Differentiation and Aggregation of Neural Stem Cells" @default.
• W3033254893 cites W1224329310 @default.
• W3033254893 cites W1589552381 @default.
• W3033254893 cites W1599737625 @default.
• W3033254893 cites W1661677144 @default.
• W3033254893 cites W1878762030 @default.
• W3033254893 cites W1966345556 @default.
• W3033254893 cites W1969418378 @default.
• W3033254893 cites W1970798179 @default.
• W3033254893 cites W1975466068 @default.
• W3033254893 cites W1985657116 @default.
• W3033254893 cites W1987145582 @default.
• W3033254893 cites W1993158184 @default.
• W3033254893 cites W2004423242 @default.
• W3033254893 cites W2004837900 @default.
• W3033254893 cites W2009738292 @default.
• W3033254893 cites W2010243889 @default.
• W3033254893 cites W2017656054 @default.
• W3033254893 cites W2018496107 @default.
• W3033254893 cites W2030355018 @default.
• W3033254893 cites W2043679754 @default.
• W3033254893 cites W2045044865 @default.
• W3033254893 cites W2047190839 @default.
• W3033254893 cites W2047573089 @default.
• W3033254893 cites W2054552572 @default.
• W3033254893 cites W2054675033 @default.
• W3033254893 cites W2063478423 @default.
• W3033254893 cites W2065569210 @default.
• W3033254893 cites W2067224145 @default.
• W3033254893 cites W2068750445 @default.
• W3033254893 cites W2075031095 @default.
• W3033254893 cites W2075089959 @default.
• W3033254893 cites W2076694212 @default.
• W3033254893 cites W2076943827 @default.
• W3033254893 cites W2076961991 @default.
• W3033254893 cites W2076971387 @default.
• W3033254893 cites W2080664885 @default.
• W3033254893 cites W2084652685 @default.
• W3033254893 cites W2088906043 @default.
• W3033254893 cites W2089394861 @default.
• W3033254893 cites W2103484879 @default.
• W3033254893 cites W2103491454 @default.
• W3033254893 cites W2110232685 @default.
• W3033254893 cites W2155661160 @default.
• W3033254893 cites W2163371631 @default.
• W3033254893 cites W2163870773 @default.
• W3033254893 cites W2166555967 @default.
• W3033254893 cites W2172266256 @default.
• W3033254893 cites W2613736016 @default.
• W3033254893 cites W2780619630 @default.
• W3033254893 cites W2789329186 @default.
• W3033254893 cites W2805899912 @default.
• W3033254893 cites W2888589558 @default.
• W3033254893 cites W2894532771 @default.
• W3033254893 cites W2910052979 @default.
• W3033254893 cites W2912649349 @default.
• W3033254893 cites W2994724123 @default.
• W3033254893 cites W4249483638 @default.
• W3033254893 doi "https://doi.org/10.1101/2020.06.06.137745" @default.
• W3033254893 hasPublicationYear "2020" @default.
• W3033254893 type Work @default.
• W3033254893 sameAs 3033254893 @default.
• W3033254893 citedByCount "0" @default.
• W3033254893 crossrefType "posted-content" @default.
• W3033254893 hasAuthorship W3033254893A5006715236 @default.
• W3033254893 hasAuthorship W3033254893A5008654532 @default.
• W3033254893 hasAuthorship W3033254893A5009374812 @default.
• W3033254893 hasAuthorship W3033254893A5026144539 @default.
• W3033254893 hasAuthorship W3033254893A5026954909 @default.
• W3033254893 hasAuthorship W3033254893A5059276823 @default.
• W3033254893 hasAuthorship W3033254893A5060453448 @default.
• W3033254893 hasAuthorship W3033254893A5077069068 @default.
• W3033254893 hasAuthorship W3033254893A5080646722 @default.
• W3033254893 hasBestOaLocation W30332548931 @default.
• W3033254893 hasConcept C104317684 @default.
• W3033254893 hasConcept C136834591 @default.
• W3033254893 hasConcept C148738053 @default.
• W3033254893 hasConcept C164027704 @default.
• W3033254893 hasConcept C169760540 @default.
• W3033254893 hasConcept C201750760 @default.
• W3033254893 hasConcept C203014093 @default.
• W3033254893 hasConcept C2776307749 @default.
• W3033254893 hasConcept C2776914184 @default.
• W3033254893 hasConcept C28328180 @default.
• W3033254893 hasConcept C55493867 @default.
• W3033254893 hasConcept C86803240 @default.
• W3033254893 hasConcept C95444343 @default.

• next