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- W3033287737 abstract "Significance The interleukin-6 family of cytokines play an increasingly recognized role in inflammation, metabolism, and tissue regeneration. Cytokine binding to CNTFR triggers JAK-STAT, MAPK, and other associated pathways. From limited studies reported to date, CLCF1 has been implicated in lung cancer, osteoporosis, and atherosclerosis, identifying the CLCF1–CNTFR signaling axis as a therapeutic target for a number of diseases. To modulate multireceptor engagement to drive cell signaling, we used rational and combinatorial protein engineering methods to create two unique CLCF1 variants: one that promotes enhanced cell signaling in neuronal regeneration and one that blocks cell signaling to inhibit tumor progression. These studies highlight an approach of engineering cytokine activity to target the CLCF1–CNTFR signaling axis." @default.
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- W3033287737 date "2020-06-10" @default.
- W3033287737 modified "2023-10-16" @default.
- W3033287737 title "Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand" @default.
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- W3033287737 doi "https://doi.org/10.1073/pnas.1922729117" @default.
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