Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033331903> ?p ?o ?g. }
- W3033331903 endingPage "e1008756" @default.
- W3033331903 startingPage "e1008756" @default.
- W3033331903 abstract "Paternal cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring, but the mechanism has not been identified. Here we use mouse models to investigate mechanisms and impacts of paternal CS exposure. We demonstrate that CS exposure induces sperm DNAme changes that are partially corrected within 28 days of removal from CS exposure. Additionally, paternal smoking is associated with changes in prefrontal cortex DNAme and gene expression patterns in offspring. Remarkably, the epigenetic and transcriptional effects of CS exposure that we observed in wild type mice are partially recapitulated in Nrf2-/- mice and their offspring, independent of smoking status. Nrf2 is a central regulator of antioxidant gene transcription, and mice lacking Nrf2 consequently display elevated oxidative stress, suggesting that oxidative stress may underlie CS-induced heritable epigenetic changes. Importantly, paternal sperm DNAme changes do not overlap with DNAme changes measured in offspring prefrontal cortex, indicating that the observed DNAme changes in sperm are not directly inherited. Additionally, the changes in sperm DNAme associated with CS exposure were not observed in sperm of unexposed offspring, suggesting the effects are likely not maintained across multiple generations." @default.
- W3033331903 created "2020-06-12" @default.
- W3033331903 creator A5001292616 @default.
- W3033331903 creator A5014154391 @default.
- W3033331903 creator A5020191126 @default.
- W3033331903 creator A5026427464 @default.
- W3033331903 creator A5028885808 @default.
- W3033331903 creator A5029714395 @default.
- W3033331903 creator A5042933114 @default.
- W3033331903 creator A5056023604 @default.
- W3033331903 creator A5057668804 @default.
- W3033331903 creator A5060287517 @default.
- W3033331903 creator A5080554846 @default.
- W3033331903 creator A5080592810 @default.
- W3033331903 date "2020-06-10" @default.
- W3033331903 modified "2023-10-16" @default.
- W3033331903 title "NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure" @default.
- W3033331903 cites W1497970422 @default.
- W3033331903 cites W1966933121 @default.
- W3033331903 cites W1968110523 @default.
- W3033331903 cites W1991459037 @default.
- W3033331903 cites W2006345816 @default.
- W3033331903 cites W2022131093 @default.
- W3033331903 cites W2022484411 @default.
- W3033331903 cites W2024166484 @default.
- W3033331903 cites W2024596480 @default.
- W3033331903 cites W2032602115 @default.
- W3033331903 cites W2033274952 @default.
- W3033331903 cites W2038379636 @default.
- W3033331903 cites W2040553259 @default.
- W3033331903 cites W2050057220 @default.
- W3033331903 cites W2067079482 @default.
- W3033331903 cites W2076935230 @default.
- W3033331903 cites W2077063343 @default.
- W3033331903 cites W2079987638 @default.
- W3033331903 cites W2101526557 @default.
- W3033331903 cites W2103008999 @default.
- W3033331903 cites W2116565281 @default.
- W3033331903 cites W2117950666 @default.
- W3033331903 cites W2118238722 @default.
- W3033331903 cites W2132289378 @default.
- W3033331903 cites W2134046656 @default.
- W3033331903 cites W2134442490 @default.
- W3033331903 cites W2137291580 @default.
- W3033331903 cites W2141289961 @default.
- W3033331903 cites W2141707748 @default.
- W3033331903 cites W2143597238 @default.
- W3033331903 cites W2145738328 @default.
- W3033331903 cites W2154750559 @default.
- W3033331903 cites W2159657105 @default.
- W3033331903 cites W2164578308 @default.
- W3033331903 cites W2201382378 @default.
- W3033331903 cites W2210080033 @default.
- W3033331903 cites W2211682249 @default.
- W3033331903 cites W2254116509 @default.
- W3033331903 cites W2468218308 @default.
- W3033331903 cites W2587651673 @default.
- W3033331903 cites W2588031543 @default.
- W3033331903 cites W2740957790 @default.
- W3033331903 cites W2759363180 @default.
- W3033331903 cites W2790270529 @default.
- W3033331903 cites W2802402149 @default.
- W3033331903 cites W2884974825 @default.
- W3033331903 cites W2894563199 @default.
- W3033331903 cites W2896896317 @default.
- W3033331903 cites W2940879919 @default.
- W3033331903 cites W2941003197 @default.
- W3033331903 cites W2944079321 @default.
- W3033331903 cites W2945458483 @default.
- W3033331903 cites W2952810015 @default.
- W3033331903 cites W2963537251 @default.
- W3033331903 cites W2997669114 @default.
- W3033331903 cites W3006284663 @default.
- W3033331903 doi "https://doi.org/10.1371/journal.pgen.1008756" @default.
- W3033331903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7307791" @default.
- W3033331903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32520939" @default.
- W3033331903 hasPublicationYear "2020" @default.
- W3033331903 type Work @default.
- W3033331903 sameAs 3033331903 @default.
- W3033331903 citedByCount "8" @default.
- W3033331903 countsByYear W30333319032020 @default.
- W3033331903 countsByYear W30333319032021 @default.
- W3033331903 countsByYear W30333319032022 @default.
- W3033331903 countsByYear W30333319032023 @default.
- W3033331903 crossrefType "journal-article" @default.
- W3033331903 hasAuthorship W3033331903A5001292616 @default.
- W3033331903 hasAuthorship W3033331903A5014154391 @default.
- W3033331903 hasAuthorship W3033331903A5020191126 @default.
- W3033331903 hasAuthorship W3033331903A5026427464 @default.
- W3033331903 hasAuthorship W3033331903A5028885808 @default.
- W3033331903 hasAuthorship W3033331903A5029714395 @default.
- W3033331903 hasAuthorship W3033331903A5042933114 @default.
- W3033331903 hasAuthorship W3033331903A5056023604 @default.
- W3033331903 hasAuthorship W3033331903A5057668804 @default.
- W3033331903 hasAuthorship W3033331903A5060287517 @default.
- W3033331903 hasAuthorship W3033331903A5080554846 @default.
- W3033331903 hasAuthorship W3033331903A5080592810 @default.
- W3033331903 hasBestOaLocation W30333319031 @default.