FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033332892> ?p ?o ?g. }

• W3033332892 endingPage "111166" @default.
• W3033332892 startingPage "111166" @default.
• W3033332892 abstract "Abstract In this work, a pH-responsive and tumor targeted multifunctional drug delivery system (RB-DOX@HMSNs-N = C-HA) was designed to realize chemo-photodynamic combination therapy. Hollow mesoporous silica nanoparticles (HMSNs) was served as the host material to encapsulate doxorubicin (DOX) and photosensitizer rose bengal (RB). Hyaluronic acid (HA) was modified on the surface of HMSNs via pH-sensitive Schiff base bonds as gatekeeper as well as targeted agent. Characterization results indicated the successful preparation of HMSNs-N = C-HA with appropriate diameter of 170 nm around and the nanocarriers displayed superior drug loading capacity (15.30 % for DOX and 12.78 % for RB). Notably, the results of in vitro drug release experiments confirmed that the system possessed good pH-sensitivity, which made it possible to release cargoes in slight acid tumor micro-environments. Significantly, the in vitro cell uptake and cytotoxicity assay results fully proved that RB-DOX@HMSNs-N = C-HA could precisely target murine mammary carcinoma (4T1) cells and effectively inhibit tumor cells viability with chemo-photodynamic synergistic therapy. Overall, our work (RB-DOX@HMSNs-N = C-HA) provides an efficient approach for the development of chemo-photodynamic combination therapy." @default.
• W3033332892 created "2020-06-12" @default.
• W3033332892 creator A5000737773 @default.
• W3033332892 creator A5023679657 @default.
• W3033332892 creator A5034346098 @default.
• W3033332892 creator A5045640752 @default.
• W3033332892 creator A5056701466 @default.
• W3033332892 creator A5059087009 @default.
• W3033332892 creator A5069511766 @default.
• W3033332892 creator A5070982004 @default.
• W3033332892 creator A5072418695 @default.
• W3033332892 creator A5074339191 @default.
• W3033332892 date "2020-10-01" @default.
• W3033332892 modified "2023-10-05" @default.
• W3033332892 title "Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy" @default.
• W3033332892 cites W1990806983 @default.
• W3033332892 cites W2010484901 @default.
• W3033332892 cites W2088659772 @default.
• W3033332892 cites W2097105120 @default.
• W3033332892 cites W2098614661 @default.
• W3033332892 cites W2100718703 @default.
• W3033332892 cites W2146182990 @default.
• W3033332892 cites W2165232616 @default.
• W3033332892 cites W2230383031 @default.
• W3033332892 cites W2323650442 @default.
• W3033332892 cites W2461025586 @default.
• W3033332892 cites W2461427772 @default.
• W3033332892 cites W2466583385 @default.
• W3033332892 cites W2566500950 @default.
• W3033332892 cites W2572184537 @default.
• W3033332892 cites W2606758599 @default.
• W3033332892 cites W2750170772 @default.
• W3033332892 cites W2751516278 @default.
• W3033332892 cites W2761082821 @default.
• W3033332892 cites W2767970173 @default.
• W3033332892 cites W2769964316 @default.
• W3033332892 cites W2783786550 @default.
• W3033332892 cites W2790338512 @default.
• W3033332892 cites W2792614705 @default.
• W3033332892 cites W2794284537 @default.
• W3033332892 cites W2801863957 @default.
• W3033332892 cites W2805394049 @default.
• W3033332892 cites W2806013947 @default.
• W3033332892 cites W2809136880 @default.
• W3033332892 cites W2810999363 @default.
• W3033332892 cites W2878039726 @default.
• W3033332892 cites W2889646458 @default.
• W3033332892 cites W2901265038 @default.
• W3033332892 cites W2902864533 @default.
• W3033332892 cites W2911188335 @default.
• W3033332892 cites W2912211938 @default.
• W3033332892 cites W2923354574 @default.
• W3033332892 cites W2929782863 @default.
• W3033332892 cites W2934302086 @default.
• W3033332892 cites W2944014003 @default.
• W3033332892 cites W2945554430 @default.
• W3033332892 cites W2965286772 @default.
• W3033332892 doi "https://doi.org/10.1016/j.colsurfb.2020.111166" @default.
• W3033332892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32521461" @default.
• W3033332892 hasPublicationYear "2020" @default.
• W3033332892 type Work @default.
• W3033332892 sameAs 3033332892 @default.
• W3033332892 citedByCount "39" @default.
• W3033332892 countsByYear W30333328922020 @default.
• W3033332892 countsByYear W30333328922021 @default.
• W3033332892 countsByYear W30333328922022 @default.
• W3033332892 countsByYear W30333328922023 @default.
• W3033332892 crossrefType "journal-article" @default.
• W3033332892 hasAuthorship W3033332892A5000737773 @default.
• W3033332892 hasAuthorship W3033332892A5023679657 @default.
• W3033332892 hasAuthorship W3033332892A5034346098 @default.
• W3033332892 hasAuthorship W3033332892A5045640752 @default.
• W3033332892 hasAuthorship W3033332892A5056701466 @default.
• W3033332892 hasAuthorship W3033332892A5059087009 @default.
• W3033332892 hasAuthorship W3033332892A5069511766 @default.
• W3033332892 hasAuthorship W3033332892A5070982004 @default.
• W3033332892 hasAuthorship W3033332892A5072418695 @default.
• W3033332892 hasAuthorship W3033332892A5074339191 @default.
• W3033332892 hasConcept C105702510 @default.
• W3033332892 hasConcept C155672457 @default.
• W3033332892 hasConcept C161790260 @default.
• W3033332892 hasConcept C171250308 @default.
• W3033332892 hasConcept C178790620 @default.
• W3033332892 hasConcept C18150654 @default.
• W3033332892 hasConcept C185592680 @default.
• W3033332892 hasConcept C192562407 @default.
• W3033332892 hasConcept C2777496208 @default.
• W3033332892 hasConcept C2777529286 @default.
• W3033332892 hasConcept C2781323092 @default.
• W3033332892 hasConcept C55493867 @default.
• W3033332892 hasConcept C71924100 @default.
• W3033332892 hasConcept C82776694 @default.
• W3033332892 hasConceptScore W3033332892C105702510 @default.
• W3033332892 hasConceptScore W3033332892C155672457 @default.
• W3033332892 hasConceptScore W3033332892C161790260 @default.
• W3033332892 hasConceptScore W3033332892C171250308 @default.
• W3033332892 hasConceptScore W3033332892C178790620 @default.
• W3033332892 hasConceptScore W3033332892C18150654 @default.

• next