FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033341377> ?p ?o ?g. }

• W3033341377 endingPage "2050038" @default.
• W3033341377 startingPage "2050038" @default.
• W3033341377 abstract "Changes in cellular Ca[Formula: see text] concentration control a variety of physiological activities including hormone and neurotransmitter release, muscular contraction, synaptic plasticity, ionic channel permeability, apoptosis, enzyme activity, gene transcription and reproduction process. Spatial–temporal Ca[Formula: see text] dynamics due to Ca[Formula: see text] release, buffering and re-uptaking plays a central role in studying the Ca[Formula: see text] regulation in T lymphocytes. In most cases, Ca[Formula: see text] has its major signaling function when it is elevated in the cytosolic compartment. In this paper, a two-dimensional mathematical model to study spatiotemporal variations of intracellular Ca[Formula: see text] concentration in T lymphocyte cell is proposed and investigated. The cell is assumed to be a circular shaped geometrical domain for the representation of properties of Ca[Formula: see text] dynamics within the cell including important parameters. Ca[Formula: see text] binding proteins for the dynamics of Ca[Formula: see text] are itself buffer and other physiological parameters located in Ca[Formula: see text] stores. The model incorporates the important biophysical processes like diffusion, reaction, voltage-gated Ca[Formula: see text] channel, leak from endoplasmic reticulum (ER), efflux from cytosol to ER via sarco–ER Ca[Formula: see text] adenosine triphosphate (SERCA) pumps, buffers and Na[Formula: see text] exchanger. The proposed mathematical model is solved using a finite difference method and the finite element method. Appropriate initial and boundary conditions are incorporated in the model based on biophysical conditions of the problem. Computer simulations in MATLAB R2019b are employed to investigate mathematical models of reaction–diffusion equation. The effect of source, buffer, Na[Formula: see text]/Ca[Formula: see text] exchanger, etc. on spatial and temporal patterns of Ca[Formula: see text] in T lymphocyte has been studied with the help of numerical results. From the obtained results, it is observed that, the coordinated combination of the incorporated parameters plays a significant role in Ca[Formula: see text] regulation in T lymphocytes. ER leak and voltage-gated Ca[Formula: see text] channel provides the necessary Ca[Formula: see text] to the cell when required for its proper functioning, while on the other side buffers, SERCA pump and Na[Formula: see text]/Ca[Formula: see text] exchanger makes balance in the Ca[Formula: see text] concentration, so as to prevent the cell from death as higher concentration for longer time is harmful for the cell and can cause cell death." @default.
• W3033341377 created "2020-06-12" @default.
• W3033341377 creator A5060484393 @default.
• W3033341377 date "2020-06-04" @default.
• W3033341377 modified "2023-10-03" @default.
• W3033341377 title "Modeling the mechanics of calcium regulation in T lymphocyte: A finite element method approach" @default.
• W3033341377 cites W107113097 @default.
• W3033341377 cites W1851568795 @default.
• W3033341377 cites W1934528477 @default.
• W3033341377 cites W1966579024 @default.
• W3033341377 cites W1972028570 @default.
• W3033341377 cites W1977012890 @default.
• W3033341377 cites W1977201959 @default.
• W3033341377 cites W1983562761 @default.
• W3033341377 cites W1984127958 @default.
• W3033341377 cites W1994348876 @default.
• W3033341377 cites W2002401337 @default.
• W3033341377 cites W2004220211 @default.
• W3033341377 cites W2007263885 @default.
• W3033341377 cites W2017245381 @default.
• W3033341377 cites W2020757483 @default.
• W3033341377 cites W2025596955 @default.
• W3033341377 cites W2040336234 @default.
• W3033341377 cites W2041748354 @default.
• W3033341377 cites W2046509930 @default.
• W3033341377 cites W2058177425 @default.
• W3033341377 cites W2076502472 @default.
• W3033341377 cites W2091432644 @default.
• W3033341377 cites W2091886117 @default.
• W3033341377 cites W2100626956 @default.
• W3033341377 cites W2108373826 @default.
• W3033341377 cites W2124487345 @default.
• W3033341377 cites W2126917206 @default.
• W3033341377 cites W2136864660 @default.
• W3033341377 cites W2139939841 @default.
• W3033341377 cites W2147925997 @default.
• W3033341377 cites W2151996073 @default.
• W3033341377 cites W2161008317 @default.
• W3033341377 cites W2166547308 @default.
• W3033341377 cites W2167653831 @default.
• W3033341377 cites W2169253528 @default.
• W3033341377 cites W2332934589 @default.
• W3033341377 cites W2335462292 @default.
• W3033341377 cites W2556019557 @default.
• W3033341377 cites W2637124715 @default.
• W3033341377 cites W2775840218 @default.
• W3033341377 cites W2793665353 @default.
• W3033341377 cites W2795347322 @default.
• W3033341377 cites W2888529304 @default.
• W3033341377 cites W4213388037 @default.
• W3033341377 cites W4249249312 @default.
• W3033341377 doi "https://doi.org/10.1142/s1793524520500382" @default.
• W3033341377 hasPublicationYear "2020" @default.
• W3033341377 type Work @default.
• W3033341377 sameAs 3033341377 @default.
• W3033341377 citedByCount "18" @default.
• W3033341377 countsByYear W30333413772020 @default.
• W3033341377 countsByYear W30333413772021 @default.
• W3033341377 countsByYear W30333413772022 @default.
• W3033341377 countsByYear W30333413772023 @default.
• W3033341377 crossrefType "journal-article" @default.
• W3033341377 hasAuthorship W3033341377A5060484393 @default.
• W3033341377 hasConcept C121332964 @default.
• W3033341377 hasConcept C12554922 @default.
• W3033341377 hasConcept C158617107 @default.
• W3033341377 hasConcept C181199279 @default.
• W3033341377 hasConcept C185592680 @default.
• W3033341377 hasConcept C46141821 @default.
• W3033341377 hasConcept C55493867 @default.
• W3033341377 hasConcept C86803240 @default.
• W3033341377 hasConcept C98539663 @default.
• W3033341377 hasConceptScore W3033341377C121332964 @default.
• W3033341377 hasConceptScore W3033341377C12554922 @default.
• W3033341377 hasConceptScore W3033341377C158617107 @default.
• W3033341377 hasConceptScore W3033341377C181199279 @default.
• W3033341377 hasConceptScore W3033341377C185592680 @default.
• W3033341377 hasConceptScore W3033341377C46141821 @default.
• W3033341377 hasConceptScore W3033341377C55493867 @default.
• W3033341377 hasConceptScore W3033341377C86803240 @default.
• W3033341377 hasConceptScore W3033341377C98539663 @default.
• W3033341377 hasFunder F4320321543 @default.
• W3033341377 hasIssue "05" @default.
• W3033341377 hasLocation W30333413771 @default.
• W3033341377 hasOpenAccess W3033341377 @default.
• W3033341377 hasPrimaryLocation W30333413771 @default.
• W3033341377 hasRelatedWork W1659820631 @default.
• W3033341377 hasRelatedWork W170006949 @default.
• W3033341377 hasRelatedWork W1997802374 @default.
• W3033341377 hasRelatedWork W2050240114 @default.
• W3033341377 hasRelatedWork W2085648931 @default.
• W3033341377 hasRelatedWork W2258310211 @default.
• W3033341377 hasRelatedWork W2895941381 @default.
• W3033341377 hasRelatedWork W2921660181 @default.
• W3033341377 hasRelatedWork W3015911368 @default.
• W3033341377 hasRelatedWork W3133981303 @default.
• W3033341377 hasVolume "13" @default.
• W3033341377 isParatext "false" @default.
• W3033341377 isRetracted "false" @default.

• next