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- W3033341721 abstract "Immunization with synthetic mRNA encoding tumor-associated antigens is an emerging vaccine strategy for the treatment of cancer. In order to prevent mRNA degradation, promote antigen-presenting cells antigen presentation, and induce an anti-tumor immune response, we investigated the nasal administration of mRNA vaccines with positively charged protamine to concentrate mRNA, form a stable polycation-mRNA complex, and encapsulate the complex with DOTAP/Chol/DSPE-PEG cationic liposomes. Cationic liposome/protamine complex (LPC) showed significantly greater efficiency in uptake of vaccine particles in vitro and stronger capacities to stimulate dendritic cell maturation, which further induced a potent anti-tumor immune response. Intranasal immunization of mice with cationic LPC containing mRNA encoding cytokeratin 19 provoked a strong cellular immune response and slowed tumor growth in an aggressive Lewis lung cancer model. The results of this study provide evidence that cationic LPC can be used as a safe and effective adjuvant and this mRNA formulation provides a basis for anti-cancer vaccination of humans." @default.
- W3033341721 created "2020-06-12" @default.
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- W3033341721 date "2020-08-01" @default.
- W3033341721 modified "2023-10-14" @default.
- W3033341721 title "Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity" @default.
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- W3033341721 doi "https://doi.org/10.1016/j.cellimm.2020.104143" @default.
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