Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033352015> ?p ?o ?g. }
- W3033352015 endingPage "2755" @default.
- W3033352015 startingPage "2736" @default.
- W3033352015 abstract "Summary Royal jelly (RJ), a brood food of honey bees, has strong antimicrobial activity. Melissococcus plutonius , the causative agent of European foulbrood of honey bees, exhibits resistance to this antimicrobial activity and infects larvae orally. Among three genetically distinct groups (CC3, CC12 and CC13) of M . plutonius , CC3 strains exhibit the strongest RJ resistance. In this study, to identify genes involved in RJ resistance, we generated an RJ‐susceptible derivative from a highly RJ‐resistant CC3 strain by UV mutagenesis. Genome sequence analysis of the derivative revealed the presence of a frameshift mutation in the putative regulator gene spxA1a . The deletion of spxA1a from a CC3 strain resulted in increased susceptibility to RJ and its antimicrobial component 10‐hydroxy‐2‐decenoic acid. Moreover, the mutant became susceptible to low‐pH and oxidative stress, which may be encountered in brood foods. Differentially expressed gene analysis using wild‐type and spxA1a mutants revealed that 45 protein‐coding genes were commonly upregulated in spxA1a ‐positive strains. Many upregulated genes were located in a prophage region, and some highly upregulated genes were annotated as universal/general stress proteins, oxidoreductase/reductase, chaperons and superoxide dismutase. These results suggest that SpxA1a is a key regulator to control the tolerance status of M . plutonius against stress in honey bee colonies." @default.
- W3033352015 created "2020-06-12" @default.
- W3033352015 creator A5026743497 @default.
- W3033352015 creator A5032259910 @default.
- W3033352015 creator A5032812750 @default.
- W3033352015 creator A5049275284 @default.
- W3033352015 creator A5091509858 @default.
- W3033352015 date "2020-06-26" @default.
- W3033352015 modified "2023-10-15" @default.
- W3033352015 title "Transcriptional regulator<scp>SpxA1a</scp>controls the resistance of the honey bee pathogen<i>Melissococcus plutonius</i>to the antimicrobial activity of royal jelly" @default.
- W3033352015 cites W1515010604 @default.
- W3033352015 cites W1534406401 @default.
- W3033352015 cites W17573219 @default.
- W3033352015 cites W1963651147 @default.
- W3033352015 cites W1966717858 @default.
- W3033352015 cites W1968305507 @default.
- W3033352015 cites W1984206296 @default.
- W3033352015 cites W1984640298 @default.
- W3033352015 cites W1987732777 @default.
- W3033352015 cites W1988539288 @default.
- W3033352015 cites W1988719815 @default.
- W3033352015 cites W1990015940 @default.
- W3033352015 cites W1991106306 @default.
- W3033352015 cites W1998090585 @default.
- W3033352015 cites W1998260381 @default.
- W3033352015 cites W1999271040 @default.
- W3033352015 cites W2008531306 @default.
- W3033352015 cites W2013299392 @default.
- W3033352015 cites W2016564965 @default.
- W3033352015 cites W2022695709 @default.
- W3033352015 cites W2027966932 @default.
- W3033352015 cites W2030966943 @default.
- W3033352015 cites W2035676472 @default.
- W3033352015 cites W2037011559 @default.
- W3033352015 cites W2039277799 @default.
- W3033352015 cites W2041630534 @default.
- W3033352015 cites W2044751201 @default.
- W3033352015 cites W2048382962 @default.
- W3033352015 cites W2055747100 @default.
- W3033352015 cites W2057659396 @default.
- W3033352015 cites W2063756105 @default.
- W3033352015 cites W2073353641 @default.
- W3033352015 cites W2087952993 @default.
- W3033352015 cites W2104441527 @default.
- W3033352015 cites W2110684484 @default.
- W3033352015 cites W2112309809 @default.
- W3033352015 cites W2112713036 @default.
- W3033352015 cites W2118103634 @default.
- W3033352015 cites W2121960517 @default.
- W3033352015 cites W2124985265 @default.
- W3033352015 cites W2131271579 @default.
- W3033352015 cites W2134526812 @default.
- W3033352015 cites W2152207030 @default.
- W3033352015 cites W2154929589 @default.
- W3033352015 cites W2168225803 @default.
- W3033352015 cites W2309968436 @default.
- W3033352015 cites W2339061008 @default.
- W3033352015 cites W2519330092 @default.
- W3033352015 cites W2530728465 @default.
- W3033352015 cites W2600830049 @default.
- W3033352015 cites W2610381774 @default.
- W3033352015 cites W2756086806 @default.
- W3033352015 cites W2765371030 @default.
- W3033352015 cites W2780241905 @default.
- W3033352015 cites W2794314960 @default.
- W3033352015 cites W2795643960 @default.
- W3033352015 cites W2883116841 @default.
- W3033352015 cites W2896885023 @default.
- W3033352015 cites W2899103459 @default.
- W3033352015 cites W2945035873 @default.
- W3033352015 doi "https://doi.org/10.1111/1462-2920.15125" @default.
- W3033352015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32519428" @default.
- W3033352015 hasPublicationYear "2020" @default.
- W3033352015 type Work @default.
- W3033352015 sameAs 3033352015 @default.
- W3033352015 citedByCount "7" @default.
- W3033352015 countsByYear W30333520152020 @default.
- W3033352015 countsByYear W30333520152021 @default.
- W3033352015 countsByYear W30333520152022 @default.
- W3033352015 countsByYear W30333520152023 @default.
- W3033352015 crossrefType "journal-article" @default.
- W3033352015 hasAuthorship W3033352015A5026743497 @default.
- W3033352015 hasAuthorship W3033352015A5032259910 @default.
- W3033352015 hasAuthorship W3033352015A5032812750 @default.
- W3033352015 hasAuthorship W3033352015A5049275284 @default.
- W3033352015 hasAuthorship W3033352015A5091509858 @default.
- W3033352015 hasBestOaLocation W30333520151 @default.
- W3033352015 hasConcept C104317684 @default.
- W3033352015 hasConcept C114265396 @default.
- W3033352015 hasConcept C143065580 @default.
- W3033352015 hasConcept C165864922 @default.
- W3033352015 hasConcept C2777818307 @default.
- W3033352015 hasConcept C2777907900 @default.
- W3033352015 hasConcept C2778027074 @default.
- W3033352015 hasConcept C33498276 @default.
- W3033352015 hasConcept C4937899 @default.
- W3033352015 hasConcept C54355233 @default.
- W3033352015 hasConcept C59822182 @default.