Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033355323> ?p ?o ?g. }
- W3033355323 endingPage "3995" @default.
- W3033355323 startingPage "3995" @default.
- W3033355323 abstract "The relatively few dopaminergic neurons in the mammalian brain are mostly located in the midbrain and regulate many important neural functions, including motor integration, cognition, emotive behaviors and reward. Therefore, alteration of their function or degeneration leads to severe neurological and neuropsychiatric diseases. Unraveling the mechanisms of midbrain dopaminergic (mDA) phenotype induction and maturation and elucidating the role of the gene network involved in the development and maintenance of these neurons is of pivotal importance to rescue or substitute these cells in order to restore dopaminergic functions. Recently, in addition to morphogens and transcription factors, microRNAs have been identified as critical players to confer mDA identity. The elucidation of the gene network involved in mDA neuron development and function will be crucial to identify early changes of mDA neurons that occur in pre-symptomatic pathological conditions, such as Parkinson’s disease. In addition, it can help to identify targets for new therapies and for cell reprogramming into mDA neurons. In this essay, we review the cascade of transcriptional and posttranscriptional regulation that confers mDA identity and regulates their functions. Additionally, we highlight certain mechanisms that offer important clues to unveil molecular pathogenesis of mDA neuron dysfunction and potential pharmacological targets for the treatment of mDA neuron dysfunction." @default.
- W3033355323 created "2020-06-12" @default.
- W3033355323 creator A5003749701 @default.
- W3033355323 creator A5009718807 @default.
- W3033355323 creator A5011689299 @default.
- W3033355323 creator A5056300947 @default.
- W3033355323 creator A5062499648 @default.
- W3033355323 date "2020-06-03" @default.
- W3033355323 modified "2023-10-18" @default.
- W3033355323 title "Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration" @default.
- W3033355323 cites W1584433563 @default.
- W3033355323 cites W1718365317 @default.
- W3033355323 cites W1755044521 @default.
- W3033355323 cites W1861860658 @default.
- W3033355323 cites W1877864810 @default.
- W3033355323 cites W1965134160 @default.
- W3033355323 cites W1965306643 @default.
- W3033355323 cites W1968034152 @default.
- W3033355323 cites W1969276438 @default.
- W3033355323 cites W1970642341 @default.
- W3033355323 cites W1971171795 @default.
- W3033355323 cites W1971910459 @default.
- W3033355323 cites W1978387829 @default.
- W3033355323 cites W1979113560 @default.
- W3033355323 cites W1980263460 @default.
- W3033355323 cites W1981437331 @default.
- W3033355323 cites W1983307813 @default.
- W3033355323 cites W1983365409 @default.
- W3033355323 cites W1986688939 @default.
- W3033355323 cites W1987028639 @default.
- W3033355323 cites W1987167495 @default.
- W3033355323 cites W1988791308 @default.
- W3033355323 cites W1998885927 @default.
- W3033355323 cites W2001148131 @default.
- W3033355323 cites W2001369242 @default.
- W3033355323 cites W2002020968 @default.
- W3033355323 cites W2003181166 @default.
- W3033355323 cites W2003367821 @default.
- W3033355323 cites W2004390998 @default.
- W3033355323 cites W2005890826 @default.
- W3033355323 cites W2007547257 @default.
- W3033355323 cites W2009327298 @default.
- W3033355323 cites W2010241816 @default.
- W3033355323 cites W2011069161 @default.
- W3033355323 cites W2011070056 @default.
- W3033355323 cites W2012797849 @default.
- W3033355323 cites W2012853055 @default.
- W3033355323 cites W2015205234 @default.
- W3033355323 cites W2016085626 @default.
- W3033355323 cites W2019028138 @default.
- W3033355323 cites W2021540928 @default.
- W3033355323 cites W2032466814 @default.
- W3033355323 cites W2033534718 @default.
- W3033355323 cites W2033810598 @default.
- W3033355323 cites W2034104365 @default.
- W3033355323 cites W2036375894 @default.
- W3033355323 cites W2037875822 @default.
- W3033355323 cites W2047626211 @default.
- W3033355323 cites W2048744825 @default.
- W3033355323 cites W2052323454 @default.
- W3033355323 cites W2058824016 @default.
- W3033355323 cites W2059362512 @default.
- W3033355323 cites W2064142828 @default.
- W3033355323 cites W2064199159 @default.
- W3033355323 cites W2064584805 @default.
- W3033355323 cites W2065677411 @default.
- W3033355323 cites W2067147530 @default.
- W3033355323 cites W2072837173 @default.
- W3033355323 cites W2073784532 @default.
- W3033355323 cites W2079289532 @default.
- W3033355323 cites W2079497700 @default.
- W3033355323 cites W2082347868 @default.
- W3033355323 cites W2082763706 @default.
- W3033355323 cites W2083731023 @default.
- W3033355323 cites W2084419567 @default.
- W3033355323 cites W2084894022 @default.
- W3033355323 cites W2088452419 @default.
- W3033355323 cites W2090285005 @default.
- W3033355323 cites W2093075439 @default.
- W3033355323 cites W2096304780 @default.
- W3033355323 cites W2102678193 @default.
- W3033355323 cites W2103575789 @default.
- W3033355323 cites W2105643617 @default.
- W3033355323 cites W2109242838 @default.
- W3033355323 cites W2109963281 @default.
- W3033355323 cites W2110665798 @default.
- W3033355323 cites W2111525324 @default.
- W3033355323 cites W2117726420 @default.
- W3033355323 cites W2118428015 @default.
- W3033355323 cites W2119375793 @default.
- W3033355323 cites W2121527315 @default.
- W3033355323 cites W2124161026 @default.
- W3033355323 cites W2127508962 @default.
- W3033355323 cites W2130128490 @default.
- W3033355323 cites W2132395574 @default.
- W3033355323 cites W2134964344 @default.
- W3033355323 cites W2138708625 @default.
- W3033355323 cites W2139296565 @default.