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• W3033366976 abstract "Ruxolitinib is a Janus kinase (JAK) inhibitor that is FDA-approved for the treatment of myelofibrosis, polycythemia vera, and acute graft-versus-host disease. Its use in treating various dermatologic diseases has been a topic of growing interest due to its favorable safety profile and targeted inhibition of several cytokines that perpetuate inflammatory skin conditions. The PubMed/MEDLINE and ClinicalTrials.gov databases were searched for literature on off-label uses of ruxolitinib in dermatology and ongoing trials studying its safety and efficacy. There is randomized controlled trial (RCT) evidence for the successful use of ruxolitinib in treating alopecia, atopic dermatitis, and psoriasis, with ongoing RCTs for its use in vitiligo. Smaller studies have confirmed the success of ruxolitinib in treating conditions such as dermatomyositis and hypereosinophilic syndrome, among others. No serious adverse effects were reported with the use of ruxolitinib in dermatology, but further research is needed to determine its efficacy, delivery route, and optimal dosing for treating dermatologic conditions." @default.
• W3033366976 created "2020-06-12" @default.
• W3033366976 creator A5010379939 @default.
• W3033366976 creator A5080264591 @default.
• W3033366976 date "2020-06-09" @default.
• W3033366976 modified "2023-10-18" @default.
• W3033366976 title "Off-label studies on ruxolitinib in dermatology: a review" @default.
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• W3033366976 doi "https://doi.org/10.1080/09546634.2020.1773385" @default.
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