FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033397478> ?p ?o ?g. }

• W3033397478 endingPage "4356" @default.
• W3033397478 startingPage "4347" @default.
• W3033397478 abstract "Long non-coding RNA (lncRNA) DSCAM-AS1 was reported to be aberrantly expressed and play pivotal roles in various human cancers. The aim of the present study was to investigate the expression and roles of DSCAM-AS1 in colon cancer (CC).Quantitative real-time PCR (qRT-PCR) was used to detect the expression of DSCAM-AS1, miR-204 and the mRNA level of SOX4. Cell proliferation and cell cycle were analyzed by MTT assay and flow cytometry, respectively. Transwell assay was used for migration capacity detection. Luciferase activity assay was conducted to verify the direct binding of DSCAM-AS1 and miR-204 or miR-204 and SOX4. The protein expression of SOX4 was determined by Western blot. Kaplan-Meier curves were calculated and the Log rank test was performed for the survival data analysis.DSCAM-AS1 was significantly upregulated in CC and high expression of DSCAM-AS1 was associated with poor prognosis in patients with colon cancer. Knockdown of DSCAM-AS1 significantly suppressed CC cells proliferation and migration. In addition, DSCAM-AS acted as a molecular sponge for miR-204 and SOX4 was identified as a direct target of miR-204 in CC. Moreover, the rescue assay revealed that miR-204 inhibition partly abolished the effects of DSCAM-AS1 knockdown on CC cells proliferation, migration and SOX4 expression.The present study demonstrated that DSCAM-AS1 acted as an oncogenic lncRNA in CC progression by regulating miR-204/SOX4 axis and DSCAM-AS1 may serve as a novel therapeutic target in the treatment of colon cancer." @default.
• W3033397478 created "2020-06-12" @default.
• W3033397478 creator A5015333812 @default.
• W3033397478 creator A5017839135 @default.
• W3033397478 creator A5029465921 @default.
• W3033397478 creator A5038201938 @default.
• W3033397478 creator A5043296622 @default.
• W3033397478 creator A5055814385 @default.
• W3033397478 creator A5064516480 @default.
• W3033397478 creator A5076290001 @default.
• W3033397478 date "2020-06-01" @default.
• W3033397478 modified "2023-10-15" @default.
• W3033397478 title "<p>LncRNA DSCAM-AS1 Promotes Colon Cancer Cells Proliferation and Migration via Regulating the miR-204/SOX4 Axis</p>" @default.
• W3033397478 cites W1898351156 @default.
• W3033397478 cites W1969045054 @default.
• W3033397478 cites W2125257793 @default.
• W3033397478 cites W2198153867 @default.
• W3033397478 cites W2289023840 @default.
• W3033397478 cites W2411701229 @default.
• W3033397478 cites W2518602763 @default.
• W3033397478 cites W2772819648 @default.
• W3033397478 cites W2781532008 @default.
• W3033397478 cites W2792541448 @default.
• W3033397478 cites W2910817051 @default.
• W3033397478 cites W2911188335 @default.
• W3033397478 cites W2948002688 @default.
• W3033397478 cites W2952197321 @default.
• W3033397478 cites W2955635907 @default.
• W3033397478 cites W2956599875 @default.
• W3033397478 cites W2969219697 @default.
• W3033397478 cites W2980820519 @default.
• W3033397478 cites W2982773139 @default.
• W3033397478 cites W2985136528 @default.
• W3033397478 cites W2990518753 @default.
• W3033397478 cites W2998573002 @default.
• W3033397478 cites W3004188263 @default.
• W3033397478 cites W3010540654 @default.
• W3033397478 cites W3024492775 @default.
• W3033397478 cites W3024959978 @default.
• W3033397478 cites W4289021236 @default.
• W3033397478 doi "https://doi.org/10.2147/cmar.s250670" @default.
• W3033397478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7293419" @default.
• W3033397478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32606930" @default.
• W3033397478 hasPublicationYear "2020" @default.
• W3033397478 type Work @default.
• W3033397478 sameAs 3033397478 @default.
• W3033397478 citedByCount "8" @default.
• W3033397478 countsByYear W30333974782021 @default.
• W3033397478 countsByYear W30333974782022 @default.
• W3033397478 countsByYear W30333974782023 @default.
• W3033397478 crossrefType "journal-article" @default.
• W3033397478 hasAuthorship W3033397478A5015333812 @default.
• W3033397478 hasAuthorship W3033397478A5017839135 @default.
• W3033397478 hasAuthorship W3033397478A5029465921 @default.
• W3033397478 hasAuthorship W3033397478A5038201938 @default.
• W3033397478 hasAuthorship W3033397478A5043296622 @default.
• W3033397478 hasAuthorship W3033397478A5055814385 @default.
• W3033397478 hasAuthorship W3033397478A5064516480 @default.
• W3033397478 hasAuthorship W3033397478A5076290001 @default.
• W3033397478 hasBestOaLocation W30333974781 @default.
• W3033397478 hasConcept C101762097 @default.
• W3033397478 hasConcept C104317684 @default.
• W3033397478 hasConcept C127561419 @default.
• W3033397478 hasConcept C139259183 @default.
• W3033397478 hasConcept C150194340 @default.
• W3033397478 hasConcept C153911025 @default.
• W3033397478 hasConcept C173396325 @default.
• W3033397478 hasConcept C2776415932 @default.
• W3033397478 hasConcept C502942594 @default.
• W3033397478 hasConcept C54355233 @default.
• W3033397478 hasConcept C553184892 @default.
• W3033397478 hasConcept C62112901 @default.
• W3033397478 hasConcept C81885089 @default.
• W3033397478 hasConcept C86803240 @default.
• W3033397478 hasConceptScore W3033397478C101762097 @default.
• W3033397478 hasConceptScore W3033397478C104317684 @default.
• W3033397478 hasConceptScore W3033397478C127561419 @default.
• W3033397478 hasConceptScore W3033397478C139259183 @default.
• W3033397478 hasConceptScore W3033397478C150194340 @default.
• W3033397478 hasConceptScore W3033397478C153911025 @default.
• W3033397478 hasConceptScore W3033397478C173396325 @default.
• W3033397478 hasConceptScore W3033397478C2776415932 @default.
• W3033397478 hasConceptScore W3033397478C502942594 @default.
• W3033397478 hasConceptScore W3033397478C54355233 @default.
• W3033397478 hasConceptScore W3033397478C553184892 @default.
• W3033397478 hasConceptScore W3033397478C62112901 @default.
• W3033397478 hasConceptScore W3033397478C81885089 @default.
• W3033397478 hasConceptScore W3033397478C86803240 @default.
• W3033397478 hasLocation W30333974781 @default.
• W3033397478 hasLocation W30333974782 @default.
• W3033397478 hasLocation W30333974783 @default.
• W3033397478 hasLocation W30333974784 @default.
• W3033397478 hasOpenAccess W3033397478 @default.
• W3033397478 hasPrimaryLocation W30333974781 @default.
• W3033397478 hasRelatedWork W2032373764 @default.
• W3033397478 hasRelatedWork W2904239912 @default.
• W3033397478 hasRelatedWork W3048105303 @default.
• W3033397478 hasRelatedWork W3103789129 @default.

• next