Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033409729> ?p ?o ?g. }
- W3033409729 endingPage "128588" @default.
- W3033409729 startingPage "128588" @default.
- W3033409729 abstract "Abstract In our previous work, we have synthesized a series of dibenzoxanthenes which showed antitumor activity. However the antiproliferation ability toward gastric cancer cells and the mechanism still is not known. Three new dibenzoxanthenes were synthesized by oxidized the binaphthol in this study. We studied the interaction between compounds and Calf thymus (CT-DNA) by electronic absorption titration, luminescence spectra, viscosity experiments and DFT computation. The mode of compounds binding with DNA was intercalation. We demonstrated that compounds inhibited the proliferation of gastric cancer cells by MTT assay. The antitumor effect of these compounds was triggered by S phase cell cycle arrest and induced the apoptosis of cells. The mitochondrial pathway of apoptosis was confirmed by the loss of mitochondrial membrane potential, the release of cyto C, the decrease expression of Bcl-2 protein and the increase expression of cleaved PARP, Bax, Bid, Bad proteins. Compounds also enhanced the concentration of calcium and ROS in SGC-7901 cells. All the above results indicated that compounds 4a-4c strongly suppressed the proliferation of gastric cancer cells via inducing cell cycle arrest and cell apoptosis, suggesting that compounds are potential novel therapeutic agents for gastric cancer." @default.
- W3033409729 created "2020-06-12" @default.
- W3033409729 creator A5007879668 @default.
- W3033409729 creator A5008768862 @default.
- W3033409729 creator A5047657728 @default.
- W3033409729 creator A5086396766 @default.
- W3033409729 date "2020-11-01" @default.
- W3033409729 modified "2023-09-24" @default.
- W3033409729 title "Novel dibenzoxanthenes compounds inhibit human gastric cancer SGC-7901 cell growth by apoptosis" @default.
- W3033409729 cites W1549270154 @default.
- W3033409729 cites W1951756999 @default.
- W3033409729 cites W1964483580 @default.
- W3033409729 cites W1967037562 @default.
- W3033409729 cites W1975402304 @default.
- W3033409729 cites W1978066824 @default.
- W3033409729 cites W1978438460 @default.
- W3033409729 cites W1988263368 @default.
- W3033409729 cites W2000234746 @default.
- W3033409729 cites W2008664172 @default.
- W3033409729 cites W2019446177 @default.
- W3033409729 cites W2020830322 @default.
- W3033409729 cites W2025128734 @default.
- W3033409729 cites W2030522976 @default.
- W3033409729 cites W2043360750 @default.
- W3033409729 cites W2051016827 @default.
- W3033409729 cites W2054550126 @default.
- W3033409729 cites W2057272948 @default.
- W3033409729 cites W2059846269 @default.
- W3033409729 cites W2059972850 @default.
- W3033409729 cites W2070640117 @default.
- W3033409729 cites W2070968914 @default.
- W3033409729 cites W2080627325 @default.
- W3033409729 cites W2088695864 @default.
- W3033409729 cites W2090595340 @default.
- W3033409729 cites W2092448272 @default.
- W3033409729 cites W2093855538 @default.
- W3033409729 cites W2117223537 @default.
- W3033409729 cites W2122587312 @default.
- W3033409729 cites W2139879957 @default.
- W3033409729 cites W2156179144 @default.
- W3033409729 cites W2207036351 @default.
- W3033409729 cites W2315191387 @default.
- W3033409729 cites W2317935136 @default.
- W3033409729 cites W2330108838 @default.
- W3033409729 cites W2401688711 @default.
- W3033409729 cites W2406361842 @default.
- W3033409729 cites W2487655635 @default.
- W3033409729 cites W2792185872 @default.
- W3033409729 cites W2803566018 @default.
- W3033409729 cites W2887327306 @default.
- W3033409729 cites W2950623893 @default.
- W3033409729 doi "https://doi.org/10.1016/j.molstruc.2020.128588" @default.
- W3033409729 hasPublicationYear "2020" @default.
- W3033409729 type Work @default.
- W3033409729 sameAs 3033409729 @default.
- W3033409729 citedByCount "2" @default.
- W3033409729 countsByYear W30334097292021 @default.
- W3033409729 countsByYear W30334097292022 @default.
- W3033409729 crossrefType "journal-article" @default.
- W3033409729 hasAuthorship W3033409729A5007879668 @default.
- W3033409729 hasAuthorship W3033409729A5008768862 @default.
- W3033409729 hasAuthorship W3033409729A5047657728 @default.
- W3033409729 hasAuthorship W3033409729A5086396766 @default.
- W3033409729 hasConcept C121608353 @default.
- W3033409729 hasConcept C126322002 @default.
- W3033409729 hasConcept C185592680 @default.
- W3033409729 hasConcept C190283241 @default.
- W3033409729 hasConcept C502942594 @default.
- W3033409729 hasConcept C55493867 @default.
- W3033409729 hasConcept C62112901 @default.
- W3033409729 hasConcept C71924100 @default.
- W3033409729 hasConcept C86803240 @default.
- W3033409729 hasConcept C96232424 @default.
- W3033409729 hasConceptScore W3033409729C121608353 @default.
- W3033409729 hasConceptScore W3033409729C126322002 @default.
- W3033409729 hasConceptScore W3033409729C185592680 @default.
- W3033409729 hasConceptScore W3033409729C190283241 @default.
- W3033409729 hasConceptScore W3033409729C502942594 @default.
- W3033409729 hasConceptScore W3033409729C55493867 @default.
- W3033409729 hasConceptScore W3033409729C62112901 @default.
- W3033409729 hasConceptScore W3033409729C71924100 @default.
- W3033409729 hasConceptScore W3033409729C86803240 @default.
- W3033409729 hasConceptScore W3033409729C96232424 @default.
- W3033409729 hasFunder F4320321001 @default.
- W3033409729 hasFunder F4320321921 @default.
- W3033409729 hasLocation W30334097291 @default.
- W3033409729 hasOpenAccess W3033409729 @default.
- W3033409729 hasPrimaryLocation W30334097291 @default.
- W3033409729 hasRelatedWork W1981600545 @default.
- W3033409729 hasRelatedWork W2010684987 @default.
- W3033409729 hasRelatedWork W2223891148 @default.
- W3033409729 hasRelatedWork W2341629494 @default.
- W3033409729 hasRelatedWork W2386605958 @default.
- W3033409729 hasRelatedWork W2501960686 @default.
- W3033409729 hasRelatedWork W2569030526 @default.
- W3033409729 hasRelatedWork W3012168770 @default.
- W3033409729 hasRelatedWork W3045868324 @default.
- W3033409729 hasRelatedWork W3156932517 @default.