FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033452142> ?p ?o ?g. }

• W3033452142 abstract "New antifungal therapies have been imperative, largely due to the increasing burden of fungal infections worldwide, limited arsenal of available antifungal compounds, and the emergence of drug resistance among a variety of pathogenic fungi. In this study, we screened a library of 1068 FDA-approved drugs to identify hits that exhibit broad-spectrum antifungal activity. Robenidine, an anticoccidial agent which has been widely used to treat coccidian infections of poultry and rabbits, was identified in the screening. Physiological concentrations of robenidine were able to significantly inhibit yeast cell growth, filamentation and biofilm formation of Candida albicans, the most extensively studied human fungal pathogen associated with infections in immunocompromised patients. Moreover, we observed a broad-spectrum antifungal activity of this compound towards fluconazole resistant clinical isolates of C. albicans and a wide range of clinically relevant fungal pathogens as well. Intriguingly, the robenidine-treated C. albicans cells conferred hypersensitivity to diverse cell wall stressors and analysis of the cell wall structure by transmission electron microscopy (TEM) showed that cell wall was severely damaged by robenidine, both implying that this compound may target the cell wall integrity signaling pathway. Indeed, after robenidine treatment we found a dose dependent increase in the phosphorylation of cell wall integrity marker Mkc1 which was decreased after long exposure. Furthermore, we provided evidence by RNA-seq and qPCR that Rlm1, the downstream transcription factor of Mkc1, may represent a potential target of robenidine. Therefore, our data suggest that robenidine, a FDA approved anti-coccidiosis drug, displays a promising and broadly effective antifungal strategy and represents a potentially repositionable candidate for the treatment of increasing fungal infections." @default.
• W3033452142 created "2020-06-12" @default.
• W3033452142 creator A5002058484 @default.
• W3033452142 creator A5010786305 @default.
• W3033452142 creator A5012302243 @default.
• W3033452142 creator A5015732550 @default.
• W3033452142 creator A5015905518 @default.
• W3033452142 creator A5021815685 @default.
• W3033452142 creator A5022852723 @default.
• W3033452142 creator A5040647242 @default.
• W3033452142 creator A5041105207 @default.
• W3033452142 creator A5044977919 @default.
• W3033452142 creator A5051363004 @default.
• W3033452142 creator A5053507328 @default.
• W3033452142 creator A5058138487 @default.
• W3033452142 creator A5067939471 @default.
• W3033452142 creator A5080798079 @default.
• W3033452142 creator A5085487243 @default.
• W3033452142 creator A5087191727 @default.
• W3033452142 creator A5090366405 @default.
• W3033452142 date "2020-06-03" @default.
• W3033452142 modified "2023-10-18" @default.
• W3033452142 title "FDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal" @default.
• W3033452142 cites W1937096033 @default.
• W3033452142 cites W1972770043 @default.
• W3033452142 cites W1974145667 @default.
• W3033452142 cites W1978970152 @default.
• W3033452142 cites W1991488616 @default.
• W3033452142 cites W1997437177 @default.
• W3033452142 cites W2001646769 @default.
• W3033452142 cites W2002379595 @default.
• W3033452142 cites W2006475796 @default.
• W3033452142 cites W2009633046 @default.
• W3033452142 cites W2014732005 @default.
• W3033452142 cites W2020932661 @default.
• W3033452142 cites W2021225422 @default.
• W3033452142 cites W2037366997 @default.
• W3033452142 cites W2047067218 @default.
• W3033452142 cites W2047682827 @default.
• W3033452142 cites W2054994755 @default.
• W3033452142 cites W2056868286 @default.
• W3033452142 cites W2058167342 @default.
• W3033452142 cites W2062951458 @default.
• W3033452142 cites W2066649608 @default.
• W3033452142 cites W2082568641 @default.
• W3033452142 cites W2087712604 @default.
• W3033452142 cites W2094061642 @default.
• W3033452142 cites W2097348235 @default.
• W3033452142 cites W2102621484 @default.
• W3033452142 cites W2110850434 @default.
• W3033452142 cites W2120043726 @default.
• W3033452142 cites W2122709457 @default.
• W3033452142 cites W2126638918 @default.
• W3033452142 cites W2134023938 @default.
• W3033452142 cites W2135741099 @default.
• W3033452142 cites W2139776848 @default.
• W3033452142 cites W2141288854 @default.
• W3033452142 cites W2141563676 @default.
• W3033452142 cites W2145577370 @default.
• W3033452142 cites W2146558016 @default.
• W3033452142 cites W2149987266 @default.
• W3033452142 cites W2153267886 @default.
• W3033452142 cites W2170764510 @default.
• W3033452142 cites W2345739108 @default.
• W3033452142 cites W2496922210 @default.
• W3033452142 cites W2537975785 @default.
• W3033452142 cites W2761420273 @default.
• W3033452142 cites W2774358439 @default.
• W3033452142 cites W2789844644 @default.
• W3033452142 cites W2803141418 @default.
• W3033452142 cites W2804827658 @default.
• W3033452142 cites W2805037990 @default.
• W3033452142 cites W2809340867 @default.
• W3033452142 cites W2811491101 @default.
• W3033452142 cites W2952718060 @default.
• W3033452142 cites W2969219099 @default.
• W3033452142 cites W2969733058 @default.
• W3033452142 cites W2972374249 @default.
• W3033452142 cites W3010980742 @default.
• W3033452142 doi "https://doi.org/10.3389/fmicb.2020.00996" @default.
• W3033452142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7283467" @default.
• W3033452142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32582050" @default.
• W3033452142 hasPublicationYear "2020" @default.
• W3033452142 type Work @default.
• W3033452142 sameAs 3033452142 @default.
• W3033452142 citedByCount "10" @default.
• W3033452142 countsByYear W30334521422020 @default.
• W3033452142 countsByYear W30334521422021 @default.
• W3033452142 countsByYear W30334521422022 @default.
• W3033452142 crossrefType "journal-article" @default.
• W3033452142 hasAuthorship W3033452142A5002058484 @default.
• W3033452142 hasAuthorship W3033452142A5010786305 @default.
• W3033452142 hasAuthorship W3033452142A5012302243 @default.
• W3033452142 hasAuthorship W3033452142A5015732550 @default.
• W3033452142 hasAuthorship W3033452142A5015905518 @default.
• W3033452142 hasAuthorship W3033452142A5021815685 @default.
• W3033452142 hasAuthorship W3033452142A5022852723 @default.
• W3033452142 hasAuthorship W3033452142A5040647242 @default.
• W3033452142 hasAuthorship W3033452142A5041105207 @default.
• W3033452142 hasAuthorship W3033452142A5044977919 @default.

• next