Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033454674> ?p ?o ?g. }
- W3033454674 endingPage "113372" @default.
- W3033454674 startingPage "113372" @default.
- W3033454674 abstract "In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to reside in the subventricular zone and the subgranular zone of the hippocampus. A large body of evidence shows that experiences such as learning, enriched environment and stress can alter proliferation and differentiation of RGL progenitor cells. The progenitor cells present in the subgranular zone of the hippocampus divide to give rise to newborn neurons that migrate to the dentate gyrus where they differentiate into adult granule neurons. These newborn neurons have been found to have a unique role in certain types of hippocampus-dependent learning and memory, including goal-directed behaviors that require pattern separation. Experimental traumatic brain injury (TBI) in rodents has been shown to alter hippocampal neurogenesis, including triggering the acute loss of newborn neurons, as well as progenitor cell hyper-proliferation. In this review, we discuss the role of hippocampal neurogenesis in learning and memory. Furthermore, we review evidence for the molecular mechanisms that contribute to newborn neuron loss, as well as increased progenitor cell proliferation after TBI. Finally, we discuss strategies aimed at enhancing neurogenesis after TBI and their possible therapeutic benefits." @default.
- W3033454674 created "2020-06-12" @default.
- W3033454674 creator A5022051759 @default.
- W3033454674 creator A5063633345 @default.
- W3033454674 creator A5075016843 @default.
- W3033454674 creator A5084884997 @default.
- W3033454674 creator A5088204580 @default.
- W3033454674 creator A5088695376 @default.
- W3033454674 date "2020-09-01" @default.
- W3033454674 modified "2023-10-16" @default.
- W3033454674 title "Traumatic brain injury and hippocampal neurogenesis: Functional implications" @default.
- W3033454674 cites W1503343518 @default.
- W3033454674 cites W1521417549 @default.
- W3033454674 cites W1550049909 @default.
- W3033454674 cites W1553183704 @default.
- W3033454674 cites W1570383310 @default.
- W3033454674 cites W1581458838 @default.
- W3033454674 cites W1592665312 @default.
- W3033454674 cites W1642619469 @default.
- W3033454674 cites W1836082148 @default.
- W3033454674 cites W1854313094 @default.
- W3033454674 cites W1892211249 @default.
- W3033454674 cites W1913745723 @default.
- W3033454674 cites W1971218073 @default.
- W3033454674 cites W1976498690 @default.
- W3033454674 cites W1977152335 @default.
- W3033454674 cites W1980499453 @default.
- W3033454674 cites W1984460802 @default.
- W3033454674 cites W1990471595 @default.
- W3033454674 cites W1994345197 @default.
- W3033454674 cites W2000520243 @default.
- W3033454674 cites W2001171907 @default.
- W3033454674 cites W2003174281 @default.
- W3033454674 cites W2004137484 @default.
- W3033454674 cites W2006075702 @default.
- W3033454674 cites W2006841345 @default.
- W3033454674 cites W2008566143 @default.
- W3033454674 cites W2012403948 @default.
- W3033454674 cites W2016961314 @default.
- W3033454674 cites W2021823732 @default.
- W3033454674 cites W2028938479 @default.
- W3033454674 cites W2029758417 @default.
- W3033454674 cites W2031057488 @default.
- W3033454674 cites W2034433299 @default.
- W3033454674 cites W2038081912 @default.
- W3033454674 cites W2046157151 @default.
- W3033454674 cites W2047455245 @default.
- W3033454674 cites W2049922114 @default.
- W3033454674 cites W2051173215 @default.
- W3033454674 cites W2053068006 @default.
- W3033454674 cites W2053127475 @default.
- W3033454674 cites W2054145123 @default.
- W3033454674 cites W2054261786 @default.
- W3033454674 cites W2057555130 @default.
- W3033454674 cites W2063466545 @default.
- W3033454674 cites W2065232910 @default.
- W3033454674 cites W2066865589 @default.
- W3033454674 cites W2069785065 @default.
- W3033454674 cites W2078070194 @default.
- W3033454674 cites W2078678809 @default.
- W3033454674 cites W2080718047 @default.
- W3033454674 cites W2084652820 @default.
- W3033454674 cites W2087082832 @default.
- W3033454674 cites W2088135834 @default.
- W3033454674 cites W2089578225 @default.
- W3033454674 cites W2089738396 @default.
- W3033454674 cites W2089813503 @default.
- W3033454674 cites W2092284040 @default.
- W3033454674 cites W2094547160 @default.
- W3033454674 cites W2096160341 @default.
- W3033454674 cites W2096192426 @default.
- W3033454674 cites W2105788666 @default.
- W3033454674 cites W2107521515 @default.
- W3033454674 cites W2111121844 @default.
- W3033454674 cites W2111191613 @default.
- W3033454674 cites W2115290127 @default.
- W3033454674 cites W2115303625 @default.
- W3033454674 cites W2117506912 @default.
- W3033454674 cites W2118555325 @default.
- W3033454674 cites W2120485135 @default.
- W3033454674 cites W2122020787 @default.
- W3033454674 cites W2130169724 @default.
- W3033454674 cites W2132504992 @default.
- W3033454674 cites W2136863044 @default.
- W3033454674 cites W2140437325 @default.
- W3033454674 cites W2145748909 @default.
- W3033454674 cites W2147326243 @default.
- W3033454674 cites W2148727841 @default.
- W3033454674 cites W2153122353 @default.
- W3033454674 cites W2154908600 @default.
- W3033454674 cites W2165654213 @default.
- W3033454674 cites W2173271778 @default.
- W3033454674 cites W2218526093 @default.
- W3033454674 cites W2268289085 @default.
- W3033454674 cites W2273912701 @default.
- W3033454674 cites W2331252089 @default.
- W3033454674 cites W2345554436 @default.
- W3033454674 cites W2355034969 @default.