FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033484175> ?p ?o ?g. }

• W3033484175 endingPage "2398" @default.
• W3033484175 startingPage "2387" @default.
• W3033484175 abstract "In several murine models of transplantation, the “cross-dressing” of recipient antigen presenting cells (APCs) with intact donor major histocompatibility complex (MHC) derived from allograft-released small extracellular vesicles (sEVs) has been recently described as a key mechanism in eliciting and sustaining alloimmune responses. Investigation of these processes in clinical organ transplantation has, however, been hampered by the lack of sensitivity of conventional instruments and assays. We have employed advanced imaging flow cytometry (iFCM) to explore the kinetics of allograft sEV release and the extent to which donor sEVs might induce cross-dressing following liver and kidney transplantation. We report for the first time that recipient APC cross-dressing can be transiently detected in the circulation shortly after liver, but not kidney, transplantation in association with the release of HLA-bearing allograft-derived sEVs. In liver transplant recipients the majority of circulating cells exhibiting donor HLA are indeed cross-dressed cells and not passenger leukocytes. In keeping with experimental animal data, the downstream functional consequences of the transfer of circulating sEVs harvested from human transplant recipients varies depending on the type of transplant and time posttransplant. sEVs released shortly after liver, but not kidney, transplantation exhibit immunoinhibitory effects that could influence liver allograft immunogenicity." @default.
• W3033484175 created "2020-06-12" @default.
• W3033484175 creator A5026251025 @default.
• W3033484175 creator A5029937461 @default.
• W3033484175 creator A5038333230 @default.
• W3033484175 creator A5041137108 @default.
• W3033484175 creator A5049005048 @default.
• W3033484175 creator A5051675830 @default.
• W3033484175 creator A5060724793 @default.
• W3033484175 creator A5067553313 @default.
• W3033484175 creator A5078940172 @default.
• W3033484175 date "2021-07-01" @default.
• W3033484175 modified "2023-10-18" @default.
• W3033484175 title "Impact of donor extracellular vesicle release on recipient cell “cross-dressing” following clinical liver and kidney transplantation" @default.
• W3033484175 cites W1796142965 @default.
• W3033484175 cites W1963711379 @default.
• W3033484175 cites W1974209230 @default.
• W3033484175 cites W2004152924 @default.
• W3033484175 cites W2007499410 @default.
• W3033484175 cites W2010883684 @default.
• W3033484175 cites W2013645766 @default.
• W3033484175 cites W2014869316 @default.
• W3033484175 cites W2050570363 @default.
• W3033484175 cites W2058938835 @default.
• W3033484175 cites W2068502683 @default.
• W3033484175 cites W2107240342 @default.
• W3033484175 cites W2111114795 @default.
• W3033484175 cites W2122211980 @default.
• W3033484175 cites W2144722668 @default.
• W3033484175 cites W2155366992 @default.
• W3033484175 cites W2162813002 @default.
• W3033484175 cites W2164783491 @default.
• W3033484175 cites W2168901628 @default.
• W3033484175 cites W2259481044 @default.
• W3033484175 cites W2291675306 @default.
• W3033484175 cites W2468654154 @default.
• W3033484175 cites W2489001340 @default.
• W3033484175 cites W2490870730 @default.
• W3033484175 cites W2528350440 @default.
• W3033484175 cites W260618237 @default.
• W3033484175 cites W2612774616 @default.
• W3033484175 cites W2754908171 @default.
• W3033484175 cites W2770429106 @default.
• W3033484175 cites W2794951161 @default.
• W3033484175 cites W2856651205 @default.
• W3033484175 cites W2991465981 @default.
• W3033484175 doi "https://doi.org/10.1111/ajt.16123" @default.
• W3033484175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32515541" @default.
• W3033484175 hasPublicationYear "2021" @default.
• W3033484175 type Work @default.
• W3033484175 sameAs 3033484175 @default.
• W3033484175 citedByCount "24" @default.
• W3033484175 countsByYear W30334841752020 @default.
• W3033484175 countsByYear W30334841752021 @default.
• W3033484175 countsByYear W30334841752022 @default.
• W3033484175 countsByYear W30334841752023 @default.
• W3033484175 crossrefType "journal-article" @default.
• W3033484175 hasAuthorship W3033484175A5026251025 @default.
• W3033484175 hasAuthorship W3033484175A5029937461 @default.
• W3033484175 hasAuthorship W3033484175A5038333230 @default.
• W3033484175 hasAuthorship W3033484175A5041137108 @default.
• W3033484175 hasAuthorship W3033484175A5049005048 @default.
• W3033484175 hasAuthorship W3033484175A5051675830 @default.
• W3033484175 hasAuthorship W3033484175A5060724793 @default.
• W3033484175 hasAuthorship W3033484175A5067553313 @default.
• W3033484175 hasAuthorship W3033484175A5078940172 @default.
• W3033484175 hasBestOaLocation W30334841751 @default.
• W3033484175 hasConcept C104317684 @default.
• W3033484175 hasConcept C126322002 @default.
• W3033484175 hasConcept C145059251 @default.
• W3033484175 hasConcept C147483822 @default.
• W3033484175 hasConcept C188280979 @default.
• W3033484175 hasConcept C202965653 @default.
• W3033484175 hasConcept C203014093 @default.
• W3033484175 hasConcept C20518536 @default.
• W3033484175 hasConcept C207936829 @default.
• W3033484175 hasConcept C2779609443 @default.
• W3033484175 hasConcept C2780091579 @default.
• W3033484175 hasConcept C2780303639 @default.
• W3033484175 hasConcept C2780868878 @default.
• W3033484175 hasConcept C2908689518 @default.
• W3033484175 hasConcept C2911091166 @default.
• W3033484175 hasConcept C2992929900 @default.
• W3033484175 hasConcept C553184892 @default.
• W3033484175 hasConcept C55493867 @default.
• W3033484175 hasConcept C71924100 @default.
• W3033484175 hasConcept C86803240 @default.
• W3033484175 hasConcept C95444343 @default.
• W3033484175 hasConceptScore W3033484175C104317684 @default.
• W3033484175 hasConceptScore W3033484175C126322002 @default.
• W3033484175 hasConceptScore W3033484175C145059251 @default.
• W3033484175 hasConceptScore W3033484175C147483822 @default.
• W3033484175 hasConceptScore W3033484175C188280979 @default.
• W3033484175 hasConceptScore W3033484175C202965653 @default.
• W3033484175 hasConceptScore W3033484175C203014093 @default.
• W3033484175 hasConceptScore W3033484175C20518536 @default.
• W3033484175 hasConceptScore W3033484175C207936829 @default.
• W3033484175 hasConceptScore W3033484175C2779609443 @default.

• next