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- W3033484579 abstract ": Primary myelofibrosis (PMF) is a rare kind of myeloproliferative neoplasm (MPN) associated with progressive cytopenia and extramedullary hematopoiesis (EMH), which characterised by clonal proliferation of myeloid cells and renal involvement in PMF is rare. We here report a case of 54-year-old man complained of foamy urine and anasarca, abdominal imaging showed obstructive uropathy, finally diagnosed with PMF and non-IgM monoclonal gammopathy of undetermined significance (MGUS). This patient had a reported history of splenohepatomegalia for unknown reason for more than 20 years, gout and urinary tract stones for more than 10 years. To confirm the diagnosis of MPN, bone marrow biopsy was done, which was suggestive of PMF. Moreover, V617F JAK2 and G543C DNMT3A mutation were found. This patient was diagnosed with goat, obstructive uropathy and renal failure which were induced by PMF, combined with non-IgM monoclonal gammopathy, which is barely reported. Therefore, this report describes a rare case and review of literature." @default.
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- W3033484579 date "2020-06-01" @default.
- W3033484579 modified "2023-09-26" @default.
- W3033484579 title "Obstructive uropathy in a patient with primary myelofibrosis and non-IgM monoclonal gammopathy of undetermined significance—a case report" @default.
- W3033484579 doi "https://doi.org/10.21037/jxym-20-48" @default.
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