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- W3033503140 abstract "The causes for preterm birth (PTB) often remain elusive. We investigated whether circulating human milk oligosaccharides (HMOs) might be involved in modulating urinary and vaginal microbiome promoting or preventing PTB. We identified here HMOs and key microbial taxa associated with indicators of PTB. Based on our results, we propose two models for how HMOs might modulate risk for PTB: (i) by changes in HMOs associated with sterile inflammation (microbiome-independent) and (ii) by HMO-driven shifts in microbiome (microbiome-dependent). Our findings will guide current efforts to better predict the risk for PTB in seemingly healthy pregnant women and also provide appropriate preventive strategies." @default.
- W3033503140 created "2020-06-12" @default.
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- W3033503140 date "2020-06-30" @default.
- W3033503140 modified "2023-10-18" @default.
- W3033503140 title "Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner" @default.
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- W3033503140 doi "https://doi.org/10.1128/msystems.00334-20" @default.
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