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• W3033505872 abstract "Abstract To successfully invade new hosts, to break host resistance as well as to move within and between plant cells, viruses and their satellites have evolved a coordinated network of protein interactions. βC1 protein encoded by specific geminiviral satellites acts as a key pathogenicity determinant. βC1 from diverse viruses undergo multiple post-translational modifications (PTMs) such as ubiquitination and phosphorylation. However, the relevance of these and other layers of PTMs in host-geminiviral interactions has not been fully understood. Here we identified the significance of a novel layer of PTMs in Synedrella yellow vein clearing virus (SyYVCV) encoded βC1 protein having well conserved SUMOylation and SUMO-interacting motifs (SIMs). We observed that SyYVCV βC1 undergoes SUMOylation in host plants as a defensive strategy against ubiquitin mediated degradation. On the contrary, SIMs encoded in βC1 mediate degradation of βC1. Both these PTMs are also essential for the function of βC1 protein since SIM and SUMOylation motif mutants failed to promote pathogenicity and viral replication in vivo . In addition, SUMOylation in different motifs of βC1 led to functionally distinct outcomes, regulating the stability and function of the βC1 protein, as well as increased global SUMOylation of host proteins. Our results indicate the presence of a novel mechanism mediating a fine balance between defence and counter-defence in which a SIM site is competitively sought for degradation and as a counter defense, βC1 undergoes SUMOylation to escape from its degradation. Summary Statement βC1 viral protein has evolved counter-defensive strategies to perturb host protein degradation pathways" @default.
• W3033505872 created "2020-06-12" @default.
• W3033505872 creator A5021094956 @default.
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• W3033505872 creator A5083023404 @default.
• W3033505872 creator A5087725258 @default.
• W3033505872 date "2020-06-05" @default.
• W3033505872 modified "2023-09-24" @default.
• W3033505872 title "Stability of Begomoviral pathogenicity determinant βC1 is modulated by mutually antagonistic SUMOylation and SIM interactions" @default.
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• W3033505872 doi "https://doi.org/10.1101/2020.06.05.135830" @default.
• W3033505872 hasPublicationYear "2020" @default.
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