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- W3033509997 abstract "ABSTRACT Little is known about the impact of naturally occurring genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate how genetic influences on mRNA translational efficiency are associated with complex disease phenotypes using a panel of rat recombinant inbred lines. We identify a locus for cardiac hypertrophy that is associated with a translatome-wide and protein length-dependent shift in translational efficiency. This master regulator primarily affects the translation of very short and very long protein-coding sequences, altering the physiological stoichiometric translation rates of sarcomere proteins. Mechanistic dissection of this locus points to altered ribosome assembly, characterized by accumulation of polysome half-mers, changed ribosomal configurations and misregulation of the small nucleolar RNA SNORA48 . We postulate that this locus enhances a pre-existing negative correlation between protein length and translation initiation in diseased hearts. Our work shows that a single genomic locus can trigger a complex, translation-driven molecular mechanism that contributes to phenotypic variability between individuals. Graphical Abstract Highlights Genetic variability impacts protein synthesis rates in a rat model for cardiac hypertrophy A trans locus affects stoichiometric translation rates of cardiac sarcomeric proteins This master regulator locus induces a global, protein length-dependent shift in translation Dysregulated ribosome assembly induces half-mer formation and affects translation initiation rate" @default.
- W3033509997 created "2020-06-12" @default.
- W3033509997 creator A5009628707 @default.
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- W3033509997 date "2020-06-06" @default.
- W3033509997 modified "2023-10-06" @default.
- W3033509997 title "Transcontrol of cardiac mRNA translation in a protein length-dependent fashion" @default.
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