FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033540417> ?p ?o ?g. }

• W3033540417 endingPage "1116" @default.
• W3033540417 startingPage "1103" @default.
• W3033540417 abstract "Objective To investigate neurodegenerative and inflammatory biomarkers in people with amyotrophic lateral sclerosis (PALS), evaluate their predictive value for ALS progression rates, and assess their utility as pharmacodynamic biomarkers for monitoring treatment effects. Methods De-identified, longitudinal plasma, and cerebrospinal fluid (CSF) samples from PALS (n = 108; 85 with samples from ≥2 visits) and controls without neurological disease (n = 41) were obtained from the Northeast ALS Consortium (NEALS) Biofluid Repository. Seventeen of 108 PALS had familial ALS, of whom 10 had C9orf72 mutations. Additional healthy control CSF samples (n = 35) were obtained from multiple sources. We stratified PALS into fast- and slow-progression subgroups using the ALS Functional Rating Scale-Revised change rate. We compared cytokines/chemokines and neurofilament (NF) levels between PALS and controls, among progression subgroups, and in those with C9orf72 mutations. Results We found significant elevations of cytokines, including MCP-1, IL-18, and neurofilaments (NFs), indicators of neurodegeneration, in PALS versus controls. Among PALS, these cytokines and NFs were significantly higher in fast-progression and C9orf72 mutation subgroups versus slow progressors. Analyte levels were generally stable over time, a key feature for monitoring treatment effects. We demonstrated that CSF/plasma neurofilament light chain (NFL) levels may predict disease progression, and stratification by NFL levels can enrich for more homogeneous patient groups. Interpretation Longitudinal stability of cytokines and NFs in PALS support their use for monitoring responses to immunomodulatory and neuroprotective treatments. NFs also have prognostic value for fast-progression patients and may be used to select similar patient subsets in clinical trials." @default.
• W3033540417 created "2020-06-12" @default.
• W3033540417 creator A5005868870 @default.
• W3033540417 creator A5021702903 @default.
• W3033540417 creator A5022932542 @default.
• W3033540417 creator A5025571618 @default.
• W3033540417 creator A5025727547 @default.
• W3033540417 creator A5035524962 @default.
• W3033540417 creator A5036652104 @default.
• W3033540417 creator A5039762494 @default.
• W3033540417 creator A5039905544 @default.
• W3033540417 creator A5047905281 @default.
• W3033540417 creator A5050706034 @default.
• W3033540417 creator A5057092035 @default.
• W3033540417 creator A5062735243 @default.
• W3033540417 creator A5070384343 @default.
• W3033540417 creator A5077751117 @default.
• W3033540417 date "2020-06-09" @default.
• W3033540417 modified "2023-10-11" @default.
• W3033540417 title "Longitudinal biomarkers in amyotrophic lateral sclerosis" @default.
• W3033540417 cites W1981929653 @default.
• W3033540417 cites W2013154697 @default.
• W3033540417 cites W2032162800 @default.
• W3033540417 cites W2046617852 @default.
• W3033540417 cites W2068037239 @default.
• W3033540417 cites W2085165928 @default.
• W3033540417 cites W2086639871 @default.
• W3033540417 cites W2089034809 @default.
• W3033540417 cites W2117813875 @default.
• W3033540417 cites W2119874037 @default.
• W3033540417 cites W2128167427 @default.
• W3033540417 cites W2135014287 @default.
• W3033540417 cites W2136911505 @default.
• W3033540417 cites W2144507462 @default.
• W3033540417 cites W2178618172 @default.
• W3033540417 cites W2415775274 @default.
• W3033540417 cites W2520147597 @default.
• W3033540417 cites W2560731570 @default.
• W3033540417 cites W2604638361 @default.
• W3033540417 cites W2612214304 @default.
• W3033540417 cites W2616124858 @default.
• W3033540417 cites W2675950738 @default.
• W3033540417 cites W2766864364 @default.
• W3033540417 cites W2783728821 @default.
• W3033540417 cites W2792689216 @default.
• W3033540417 cites W2884390718 @default.
• W3033540417 cites W2888662179 @default.
• W3033540417 cites W2888898379 @default.
• W3033540417 cites W2909422691 @default.
• W3033540417 cites W2910657247 @default.
• W3033540417 cites W2915925525 @default.
• W3033540417 cites W2923484387 @default.
• W3033540417 cites W2924086781 @default.
• W3033540417 cites W2939958603 @default.
• W3033540417 cites W2946911440 @default.
• W3033540417 cites W2948784713 @default.
• W3033540417 cites W2969622819 @default.
• W3033540417 cites W2977216525 @default.
• W3033540417 cites W2982367931 @default.
• W3033540417 cites W2995441829 @default.
• W3033540417 doi "https://doi.org/10.1002/acn3.51078" @default.
• W3033540417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7359115" @default.
• W3033540417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32515902" @default.
• W3033540417 hasPublicationYear "2020" @default.
• W3033540417 type Work @default.
• W3033540417 sameAs 3033540417 @default.
• W3033540417 citedByCount "54" @default.
• W3033540417 countsByYear W30335404172020 @default.
• W3033540417 countsByYear W30335404172021 @default.
• W3033540417 countsByYear W30335404172022 @default.
• W3033540417 countsByYear W30335404172023 @default.
• W3033540417 crossrefType "journal-article" @default.
• W3033540417 hasAuthorship W3033540417A5005868870 @default.
• W3033540417 hasAuthorship W3033540417A5021702903 @default.
• W3033540417 hasAuthorship W3033540417A5022932542 @default.
• W3033540417 hasAuthorship W3033540417A5025571618 @default.
• W3033540417 hasAuthorship W3033540417A5025727547 @default.
• W3033540417 hasAuthorship W3033540417A5035524962 @default.
• W3033540417 hasAuthorship W3033540417A5036652104 @default.
• W3033540417 hasAuthorship W3033540417A5039762494 @default.
• W3033540417 hasAuthorship W3033540417A5039905544 @default.
• W3033540417 hasAuthorship W3033540417A5047905281 @default.
• W3033540417 hasAuthorship W3033540417A5050706034 @default.
• W3033540417 hasAuthorship W3033540417A5057092035 @default.
• W3033540417 hasAuthorship W3033540417A5062735243 @default.
• W3033540417 hasAuthorship W3033540417A5070384343 @default.
• W3033540417 hasAuthorship W3033540417A5077751117 @default.
• W3033540417 hasBestOaLocation W30335404171 @default.
• W3033540417 hasConcept C126322002 @default.
• W3033540417 hasConcept C13373296 @default.
• W3033540417 hasConcept C143998085 @default.
• W3033540417 hasConcept C203014093 @default.
• W3033540417 hasConcept C25498285 @default.
• W3033540417 hasConcept C2776914184 @default.
• W3033540417 hasConcept C2776925932 @default.
• W3033540417 hasConcept C2777898937 @default.
• W3033540417 hasConcept C2778641062 @default.
• W3033540417 hasConcept C2779134260 @default.

• next