FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033542218> ?p ?o ?g. }

• W3033542218 endingPage "289" @default.
• W3033542218 startingPage "277" @default.
• W3033542218 abstract "The dorsomedial nucleus of the hypothalamus (DMH) plays an important role in the regulation of energy intake and expenditure. Numerous appetite-regulatory signals present in the DMH, including nitric oxide (NO) and endogenous cannabinoids (eCBs), act to regulate food intake, but whether these signals are involved in regulating high fat food intake remains unknown. We therefore asked whether NO and eCBs, administered alone or in combination, would influence the consumption of high fat food in rats. We implanted bilateral guide cannulas in the DMH of young, male Sprague-Dawley rats for microinjection of vehicle, NO (via the precursor l-arginine), the eCB 2-arachidonylglycerol (2-AG), or a combination of the two signals. Following the intrahypothalamic injections, both high fat food intake and body weight were measured for two hours at which point brains were removed and sectioned to confirm cannula placement in the DMH. Here we show that l-arginine significantly increases high fat food intake when administered into the DMH. This effect is abolished in the presence of 2-AG, which alone has no effect on high fat food intake or body weight. The l-arginine-induced increase in high fat food intake is dependent on NO synthesis, as it is prevented with the NO synthase inhibitor, l-NAME. We also demonstrate that l-arginine increases glutamate transmission onto DMH neurons, an effect that also requires NO synthesis and is abolished with 2-AG. Together, these data indicate that NO acts in the DMH to regulate the consumption of high fat food, possibly by enhancing glutamate signaling at DMH synapses." @default.
• W3033542218 created "2020-06-12" @default.
• W3033542218 creator A5018680691 @default.
• W3033542218 creator A5035599084 @default.
• W3033542218 creator A5078906229 @default.
• W3033542218 date "2020-08-01" @default.
• W3033542218 modified "2023-09-26" @default.
• W3033542218 title "Nitric Oxide Acts in the Rat Dorsomedial Hypothalamus to Increase High Fat Food Intake and Glutamate Transmission" @default.
• W3033542218 cites W1495726008 @default.
• W3033542218 cites W1570762301 @default.
• W3033542218 cites W1573604208 @default.
• W3033542218 cites W1824110706 @default.
• W3033542218 cites W1941683315 @default.
• W3033542218 cites W1948588668 @default.
• W3033542218 cites W1963482720 @default.
• W3033542218 cites W1966277324 @default.
• W3033542218 cites W1980787499 @default.
• W3033542218 cites W1981147834 @default.
• W3033542218 cites W1982604009 @default.
• W3033542218 cites W1988263555 @default.
• W3033542218 cites W1989454542 @default.
• W3033542218 cites W1998776908 @default.
• W3033542218 cites W2001384875 @default.
• W3033542218 cites W2001803470 @default.
• W3033542218 cites W2002724833 @default.
• W3033542218 cites W2003637435 @default.
• W3033542218 cites W2008868341 @default.
• W3033542218 cites W2010487701 @default.
• W3033542218 cites W2015825816 @default.
• W3033542218 cites W2018305067 @default.
• W3033542218 cites W2028164195 @default.
• W3033542218 cites W2030326316 @default.
• W3033542218 cites W2037851198 @default.
• W3033542218 cites W2037898861 @default.
• W3033542218 cites W2042456996 @default.
• W3033542218 cites W2046739107 @default.
• W3033542218 cites W2050186976 @default.
• W3033542218 cites W2064128689 @default.
• W3033542218 cites W2072913140 @default.
• W3033542218 cites W2079291209 @default.
• W3033542218 cites W2081361091 @default.
• W3033542218 cites W2083064848 @default.
• W3033542218 cites W2089861942 @default.
• W3033542218 cites W2099878623 @default.
• W3033542218 cites W2101301575 @default.
• W3033542218 cites W2104298523 @default.
• W3033542218 cites W2109898272 @default.
• W3033542218 cites W2123399227 @default.
• W3033542218 cites W2128950440 @default.
• W3033542218 cites W2141943897 @default.
• W3033542218 cites W2142259845 @default.
• W3033542218 cites W2142909425 @default.
• W3033542218 cites W2145146488 @default.
• W3033542218 cites W2159606858 @default.
• W3033542218 cites W2266587081 @default.
• W3033542218 cites W2338796210 @default.
• W3033542218 cites W2410340802 @default.
• W3033542218 cites W2460483755 @default.
• W3033542218 cites W2461517048 @default.
• W3033542218 cites W2576113955 @default.
• W3033542218 cites W2595813537 @default.
• W3033542218 cites W2766153299 @default.
• W3033542218 cites W2770151730 @default.
• W3033542218 cites W2784409775 @default.
• W3033542218 cites W2886309153 @default.
• W3033542218 cites W2908373753 @default.
• W3033542218 cites W2914091513 @default.
• W3033542218 cites W2947591807 @default.
• W3033542218 cites W2953717946 @default.
• W3033542218 cites W2962256421 @default.
• W3033542218 cites W2969334710 @default.
• W3033542218 cites W4296759786 @default.
• W3033542218 doi "https://doi.org/10.1016/j.neuroscience.2020.05.039" @default.
• W3033542218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32505747" @default.
• W3033542218 hasPublicationYear "2020" @default.
• W3033542218 type Work @default.
• W3033542218 sameAs 3033542218 @default.
• W3033542218 citedByCount "3" @default.
• W3033542218 countsByYear W30335422182021 @default.
• W3033542218 countsByYear W30335422182022 @default.
• W3033542218 countsByYear W30335422182023 @default.
• W3033542218 crossrefType "journal-article" @default.
• W3033542218 hasAuthorship W3033542218A5018680691 @default.
• W3033542218 hasAuthorship W3033542218A5035599084 @default.
• W3033542218 hasAuthorship W3033542218A5078906229 @default.
• W3033542218 hasConcept C126322002 @default.
• W3033542218 hasConcept C134018914 @default.
• W3033542218 hasConcept C16613235 @default.
• W3033542218 hasConcept C170493617 @default.
• W3033542218 hasConcept C185592680 @default.
• W3033542218 hasConcept C2776552330 @default.
• W3033542218 hasConcept C2777003273 @default.
• W3033542218 hasConcept C2777468819 @default.
• W3033542218 hasConcept C2992518758 @default.
• W3033542218 hasConcept C3018685816 @default.
• W3033542218 hasConcept C511355011 @default.
• W3033542218 hasConcept C515207424 @default.
• W3033542218 hasConcept C519581460 @default.

• next