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• W3033555890 endingPage "383" @default.
• W3033555890 startingPage "369" @default.
• W3033555890 abstract "Desmopressin is a synthetic analogue of the natural antidiuretic hormone arginine vasopressin. Over the years, it has been clinically used to manage nocturnal polyuria in children with enuresis. Various pharmaceutical formulations of desmopressin have been commercialized for this indication—nasal spray, nasal drops, oral tablet and oral lyophilizate. Despite the fact that desmopressin is a frequently prescribed drug in children, its use and posology is based on limited pediatric data. This review provides an overview of the current pediatric pharmacological data related to the different desmopressin formulations, including their pharmacokinetics, pharmacodynamics and adverse events. Regarding the pharmacokinetics, a profound food effect on the oral bioavailability was demonstrated as well as different plasma concentration–time profiles (double absorption peak) of the desmopressin lyophilizate between adults and children. Literature about maturational differences in distribution, metabolism and excretion of desmopressin is rather limited. Regarding the pharmacodynamics, formulation/dose/food effect and predictors of response were evaluated. The lyophilizate is the preferred formulation, but the claimed bioequivalence in adults (200 µg tablet and 120 µg lyophilizate), could not be readily extrapolated to children. Prescribing the standard flat-dose regimen to the entire pediatric population might be insufficient to attain response to desmopressin treatment, whereby dosing schemes based on age and weight were proposed. Moreover, response to desmopressin is variable, whereby complete-, partial- and non-responders are reported. Different reasons were enumerated that might explain the difference in response rate to desmopressin observed: different pathophysiological mechanisms, bladder capacity and other predictive factors (i.e. breast feeding, familial history, compliance, sex, etc.). Also, the relapse rate of desmopressin treatment was high, rendering it necessary to use a pragmatic approach for the treatment of enuresis, whereby careful consideration of the position of desmopressin within this treatment is required. Regarding the safety of the different desmopressin formulations, the use of desmopressin was generally considered safe, but additional measures should be taken to prevent severe hyponatremia. To conclude the review, to date, major knowledge gaps in pediatric pharmacological aspects of the different desmopressin formulations still remain. Additional information should be collected about the clinical relevance of the double absorption peak, the food effect, the bioequivalence/therapeutic equivalence, the pediatric adapted dosing regimens, the study endpoints and the difference between performing studies at daytime or at nighttime. To fill in these gaps, additional well designed pharmacokinetic and pharmacodynamic studies in children should be performed." @default.
• W3033555890 created "2020-06-12" @default.
• W3033555890 creator A5012848308 @default.
• W3033555890 creator A5032893370 @default.
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• W3033555890 creator A5053984741 @default.
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• W3033555890 creator A5087769725 @default.
• W3033555890 date "2020-06-08" @default.
• W3033555890 modified "2023-10-16" @default.
• W3033555890 title "Pediatric Pharmacology of Desmopressin in Children with Enuresis: A Comprehensive Review" @default.
• W3033555890 cites W1481088047 @default.
• W3033555890 cites W1489698388 @default.
• W3033555890 cites W1765311263 @default.
• W3033555890 cites W1865234613 @default.
• W3033555890 cites W1971943018 @default.
• W3033555890 cites W1974200017 @default.
• W3033555890 cites W1976387462 @default.
• W3033555890 cites W1978288695 @default.
• W3033555890 cites W1981652536 @default.
• W3033555890 cites W1983069437 @default.
• W3033555890 cites W1984851899 @default.
• W3033555890 cites W1987559147 @default.
• W3033555890 cites W1989574773 @default.
• W3033555890 cites W1990358002 @default.
• W3033555890 cites W1993468607 @default.
• W3033555890 cites W1994039738 @default.
• W3033555890 cites W1995627578 @default.
• W3033555890 cites W1996553139 @default.
• W3033555890 cites W1997815032 @default.
• W3033555890 cites W1998316071 @default.
• W3033555890 cites W1999351778 @default.
• W3033555890 cites W2002584235 @default.
• W3033555890 cites W2005845111 @default.
• W3033555890 cites W2006282399 @default.
• W3033555890 cites W2006387676 @default.
• W3033555890 cites W2006526972 @default.
• W3033555890 cites W2009625540 @default.
• W3033555890 cites W2010332894 @default.
• W3033555890 cites W2010820521 @default.
• W3033555890 cites W2013058870 @default.
• W3033555890 cites W2016548984 @default.
• W3033555890 cites W2018537320 @default.
• W3033555890 cites W2020958409 @default.
• W3033555890 cites W2024703456 @default.
• W3033555890 cites W2028142101 @default.
• W3033555890 cites W2033439047 @default.
• W3033555890 cites W2034104348 @default.
• W3033555890 cites W2036958791 @default.
• W3033555890 cites W2037976451 @default.
• W3033555890 cites W2038092217 @default.
• W3033555890 cites W2040832831 @default.
• W3033555890 cites W2043553193 @default.
• W3033555890 cites W2043628975 @default.
• W3033555890 cites W2047183822 @default.
• W3033555890 cites W2050535768 @default.
• W3033555890 cites W2052088932 @default.
• W3033555890 cites W2058059747 @default.
• W3033555890 cites W2060080956 @default.
• W3033555890 cites W2060828834 @default.
• W3033555890 cites W2063738721 @default.
• W3033555890 cites W2064074420 @default.
• W3033555890 cites W2064257397 @default.
• W3033555890 cites W2064672412 @default.
• W3033555890 cites W2064819957 @default.
• W3033555890 cites W2065831906 @default.
• W3033555890 cites W2066630069 @default.
• W3033555890 cites W2068103266 @default.
• W3033555890 cites W2069938368 @default.
• W3033555890 cites W2071403175 @default.
• W3033555890 cites W2072497643 @default.
• W3033555890 cites W2073642196 @default.
• W3033555890 cites W2074589264 @default.
• W3033555890 cites W2076490856 @default.
• W3033555890 cites W2076850987 @default.
• W3033555890 cites W2077010625 @default.
• W3033555890 cites W2078447331 @default.
• W3033555890 cites W2079591141 @default.
• W3033555890 cites W2082288527 @default.
• W3033555890 cites W2082964231 @default.
• W3033555890 cites W2086045773 @default.
• W3033555890 cites W2090530243 @default.
• W3033555890 cites W2093028220 @default.
• W3033555890 cites W2094817289 @default.
• W3033555890 cites W2098309855 @default.
• W3033555890 cites W2103651135 @default.
• W3033555890 cites W2104400232 @default.
• W3033555890 cites W2105887556 @default.
• W3033555890 cites W2106997418 @default.
• W3033555890 cites W2113561590 @default.
• W3033555890 cites W2114515246 @default.
• W3033555890 cites W2117959567 @default.
• W3033555890 cites W2119585411 @default.
• W3033555890 cites W2120658813 @default.
• W3033555890 cites W2124777172 @default.

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