Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033575327> ?p ?o ?g. }
- W3033575327 endingPage "110276" @default.
- W3033575327 startingPage "110276" @default.
- W3033575327 abstract "Lentiviral vectors (LVs) have provided an efficient way to integrate our gene of interest into eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied to become an invaluable asset in gene delivery. This abled LVs to be used in both research laboratories and gene therapy. Pseudotyping HIV-1 based LVs, abled it to transduce different types of cells, especially hematopoietic stem cells. A wide range of tropism, plus to the ability to integrate genes into target cells, made LVs an armamentarium in gene therapy. The third and fourth generations of self-inactivating LVs are being used to achieve safe gene therapy. Not only advanced methods enabled the clinical-grade LV production on a large scale, but also considerably heightened transduction efficiency. One of which is microfluidic systems that revolutionized gene delivery approaches. Since gene therapy using LVs attracted lots of attention to itself, we provided a brief review of LV structure and life-cycle along with methods for improving both LV production and transduction. Also, we mentioned some of their utilization in immunotherapy and gene therapy." @default.
- W3033575327 created "2020-06-12" @default.
- W3033575327 creator A5001087591 @default.
- W3033575327 creator A5020025721 @default.
- W3033575327 creator A5057755011 @default.
- W3033575327 creator A5066365901 @default.
- W3033575327 creator A5082295998 @default.
- W3033575327 date "2020-08-01" @default.
- W3033575327 modified "2023-09-30" @default.
- W3033575327 title "Concise review on optimized methods in production and transduction of lentiviral vectors in order to facilitate immunotherapy and gene therapy" @default.
- W3033575327 cites W103437854 @default.
- W3033575327 cites W1425216227 @default.
- W3033575327 cites W144183931 @default.
- W3033575327 cites W1535490554 @default.
- W3033575327 cites W1538642163 @default.
- W3033575327 cites W1556946899 @default.
- W3033575327 cites W1788853185 @default.
- W3033575327 cites W1965017622 @default.
- W3033575327 cites W1965094062 @default.
- W3033575327 cites W1980192086 @default.
- W3033575327 cites W1981449360 @default.
- W3033575327 cites W1981802925 @default.
- W3033575327 cites W1985256996 @default.
- W3033575327 cites W1988214449 @default.
- W3033575327 cites W1991668507 @default.
- W3033575327 cites W1993259584 @default.
- W3033575327 cites W1997463594 @default.
- W3033575327 cites W1998643766 @default.
- W3033575327 cites W1999595668 @default.
- W3033575327 cites W1999977344 @default.
- W3033575327 cites W2000337153 @default.
- W3033575327 cites W2004291887 @default.
- W3033575327 cites W2004462834 @default.
- W3033575327 cites W2008943991 @default.
- W3033575327 cites W2009241639 @default.
- W3033575327 cites W2009761723 @default.
- W3033575327 cites W2010458160 @default.
- W3033575327 cites W2010577903 @default.
- W3033575327 cites W2015153666 @default.
- W3033575327 cites W2018325561 @default.
- W3033575327 cites W2018609975 @default.
- W3033575327 cites W2027539193 @default.
- W3033575327 cites W2029790612 @default.
- W3033575327 cites W2031875199 @default.
- W3033575327 cites W2035444138 @default.
- W3033575327 cites W2041208222 @default.
- W3033575327 cites W2042862052 @default.
- W3033575327 cites W2043011805 @default.
- W3033575327 cites W2046963695 @default.
- W3033575327 cites W2047452261 @default.
- W3033575327 cites W2049340874 @default.
- W3033575327 cites W2051622847 @default.
- W3033575327 cites W2052575262 @default.
- W3033575327 cites W2058768365 @default.
- W3033575327 cites W2060523316 @default.
- W3033575327 cites W2061568696 @default.
- W3033575327 cites W2063246268 @default.
- W3033575327 cites W2064216963 @default.
- W3033575327 cites W2067229421 @default.
- W3033575327 cites W2067290715 @default.
- W3033575327 cites W2068286575 @default.
- W3033575327 cites W2069090326 @default.
- W3033575327 cites W2070780294 @default.
- W3033575327 cites W2070881126 @default.
- W3033575327 cites W2072916562 @default.
- W3033575327 cites W2073246940 @default.
- W3033575327 cites W2075741684 @default.
- W3033575327 cites W2075895937 @default.
- W3033575327 cites W2076891452 @default.
- W3033575327 cites W2078891878 @default.
- W3033575327 cites W2086651005 @default.
- W3033575327 cites W2088240772 @default.
- W3033575327 cites W2089319449 @default.
- W3033575327 cites W2090798040 @default.
- W3033575327 cites W2094961897 @default.
- W3033575327 cites W2096176271 @default.
- W3033575327 cites W2099491642 @default.
- W3033575327 cites W2101981348 @default.
- W3033575327 cites W2102274109 @default.
- W3033575327 cites W2111021707 @default.
- W3033575327 cites W2117867057 @default.
- W3033575327 cites W2119296588 @default.
- W3033575327 cites W2131731195 @default.
- W3033575327 cites W2135332827 @default.
- W3033575327 cites W2136274459 @default.
- W3033575327 cites W2140226886 @default.
- W3033575327 cites W2141570423 @default.
- W3033575327 cites W2142159826 @default.
- W3033575327 cites W2142456569 @default.
- W3033575327 cites W2146299708 @default.
- W3033575327 cites W2146923102 @default.
- W3033575327 cites W2153955991 @default.
- W3033575327 cites W2159507231 @default.
- W3033575327 cites W2165726585 @default.
- W3033575327 cites W2165957545 @default.
- W3033575327 cites W2169250825 @default.
- W3033575327 cites W2305494742 @default.
- W3033575327 cites W2328438661 @default.