Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033585575> ?p ?o ?g. }
- W3033585575 abstract "Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1R and histamine H3 receptors (H3R). Using an HD mouse striatal cell model and HD mouse organotypic brain slices we found that D1R-induced cell death signaling and neuronal degeneration, are mitigated by an H3R antagonist. We demonstrate that the D1R-H3R heteromer is expressed in HD mice at early but not late stages of HD, correlating with HD progression. In accordance, we found this target expressed in human control subjects and low-grade HD patients. Finally, treatment of HD mice with an H3R antagonist prevented cognitive and motor learning deficits and the loss of heteromer expression. Taken together, our results indicate that D1R - H3R heteromers play a pivotal role in dopamine signaling and represent novel targets for treating HD." @default.
- W3033585575 created "2020-06-12" @default.
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- W3033585575 date "2020-06-09" @default.
- W3033585575 modified "2023-10-17" @default.
- W3033585575 title "Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease" @default.
- W3033585575 cites W1503601165 @default.
- W3033585575 cites W1606808023 @default.
- W3033585575 cites W1878860530 @default.
- W3033585575 cites W1905860502 @default.
- W3033585575 cites W1965414505 @default.
- W3033585575 cites W1966244470 @default.
- W3033585575 cites W1968180135 @default.
- W3033585575 cites W1972840565 @default.
- W3033585575 cites W1973555325 @default.
- W3033585575 cites W1974931223 @default.
- W3033585575 cites W1977569817 @default.
- W3033585575 cites W1977860760 @default.
- W3033585575 cites W1978386512 @default.
- W3033585575 cites W1978623496 @default.
- W3033585575 cites W1979333165 @default.
- W3033585575 cites W1981298128 @default.
- W3033585575 cites W1983402821 @default.
- W3033585575 cites W1984221300 @default.
- W3033585575 cites W1986411734 @default.
- W3033585575 cites W1986475550 @default.
- W3033585575 cites W1990368217 @default.
- W3033585575 cites W1990593389 @default.
- W3033585575 cites W1993068285 @default.
- W3033585575 cites W1994498762 @default.
- W3033585575 cites W1995119071 @default.
- W3033585575 cites W2000197702 @default.
- W3033585575 cites W2000673652 @default.
- W3033585575 cites W2001495408 @default.
- W3033585575 cites W2002630545 @default.
- W3033585575 cites W2003314029 @default.
- W3033585575 cites W2003872694 @default.
- W3033585575 cites W2006385634 @default.
- W3033585575 cites W2011930674 @default.
- W3033585575 cites W2013780985 @default.
- W3033585575 cites W2018254952 @default.
- W3033585575 cites W2020453673 @default.
- W3033585575 cites W2022863516 @default.
- W3033585575 cites W2024526921 @default.
- W3033585575 cites W2026124745 @default.
- W3033585575 cites W2027460679 @default.
- W3033585575 cites W2029021490 @default.
- W3033585575 cites W2032287572 @default.
- W3033585575 cites W2032297237 @default.
- W3033585575 cites W2042088692 @default.
- W3033585575 cites W2046835548 @default.
- W3033585575 cites W2051634852 @default.
- W3033585575 cites W2051716212 @default.
- W3033585575 cites W2052102717 @default.
- W3033585575 cites W2053096012 @default.
- W3033585575 cites W2057279990 @default.
- W3033585575 cites W2058321088 @default.
- W3033585575 cites W2058364486 @default.
- W3033585575 cites W2058407325 @default.
- W3033585575 cites W2059581034 @default.
- W3033585575 cites W2060545685 @default.
- W3033585575 cites W2062682951 @default.
- W3033585575 cites W2064636913 @default.
- W3033585575 cites W2065306196 @default.
- W3033585575 cites W2067297186 @default.
- W3033585575 cites W2077072108 @default.
- W3033585575 cites W2079529409 @default.
- W3033585575 cites W2080690616 @default.
- W3033585575 cites W2082056883 @default.
- W3033585575 cites W2083075330 @default.
- W3033585575 cites W2085275470 @default.
- W3033585575 cites W2087028922 @default.
- W3033585575 cites W2087698675 @default.
- W3033585575 cites W2097744565 @default.
- W3033585575 cites W2097801108 @default.
- W3033585575 cites W2106116883 @default.
- W3033585575 cites W2107356497 @default.
- W3033585575 cites W2111727127 @default.
- W3033585575 cites W2117341801 @default.
- W3033585575 cites W2118200565 @default.
- W3033585575 cites W2118546680 @default.
- W3033585575 cites W2119660954 @default.
- W3033585575 cites W2121642311 @default.