FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033590698> ?p ?o ?g. }

• W3033590698 endingPage "102472" @default.
• W3033590698 startingPage "102472" @default.
• W3033590698 abstract "Whether combining Chinese herbal medicines (CHMs) and chemotherapy to treat patients with advanced non-small-cell lung cancer (NSCLC) has clinical benefits has yet to be confirmed. A meta-analysis was performed to address the efficacy of CHM in patients with advanced NSCLC. Seven databases, including PubMed, MEDLINE, Cochrane Library, Embase, CINAHL Plus with Full Text (EBSCO), WANFANG DATA and the Chinese National Knowledge Infrastructure (CNKI), were systematically searched for available literature through March10, 2020. A meta-analysis was conducted to generate combined risk ratios(RRs) with 95 % confidence intervals (CIs) for objective response rates (ORRs), disease control rates (DCRs), and 1-year overall survival (OS) rates, and a random-effects model was used to estimate the standardized mean differences (SMDs) with 95 % CI for quality or life (QOL), median survival time (mST) and progression-free survival (PFS). Reports of 14 randomized controlled trials involving 1451 patients were included in the analysis. Among them, 739 patients received CHMs, and 712 patients received chemotherapy alone. The ORR (RR = 1.37, 95 % CI [1.20‐1.58], p = .000), DCR (RR = 1.13, 95 % CI [1.07‐1.21], p = 0.000), QOL (SMD = 1.47; 95 % CI [0.30–2.64]; p = 0.014), mST (SMD = 1.62; 95 % CI [1.15‐2.08];p = .000), and 1-year OS rate (RR = 1.24, 95 % CI [1.05‐1.47], p = 0.01) were higher in patients with NSCLC who received CHMs than in those who received only chemotherapy. However, the CHM group was not found to have a higher median PFS (SMD = 1.27, 95 % CI [-0.22‐2.78], p = .095) than the chemotherapy group. Publication bias for ORR and DCR was indicated by funnel plot. For the efficacy endpoint, no evidence of a lack of robustness was found, according to the sensitivity analysis. These results must be interpreted with caution due to differences in the designs of the trials and patients’ characteristics, and also due to the presence of missing data. Our study found that higher ORR, DCR, QOL, mST and 1-year OS rate were associated with CHM use as an adjuvant to chemotherapy. Although these results require further confirmation, CHMs apparently have potential therapeutic value for patients with advanced NSCLC." @default.
• W3033590698 created "2020-06-12" @default.
• W3033590698 creator A5008090849 @default.
• W3033590698 creator A5027607245 @default.
• W3033590698 creator A5039627897 @default.
• W3033590698 creator A5043266967 @default.
• W3033590698 creator A5090952663 @default.
• W3033590698 date "2020-08-01" @default.
• W3033590698 modified "2023-09-30" @default.
• W3033590698 title "Systematic review and meta-analysis of Chinese herbal medicine as adjuvant treatment in advanced non-small cell lung cancer patients" @default.
• W3033590698 cites W1970386532 @default.
• W3033590698 cites W1974045981 @default.
• W3033590698 cites W1977093042 @default.
• W3033590698 cites W1986215651 @default.
• W3033590698 cites W2001826948 @default.
• W3033590698 cites W2014923137 @default.
• W3033590698 cites W2066993094 @default.
• W3033590698 cites W2129992678 @default.
• W3033590698 cites W2138705226 @default.
• W3033590698 cites W2143121686 @default.
• W3033590698 cites W2157823046 @default.
• W3033590698 cites W2160260402 @default.
• W3033590698 cites W2206879497 @default.
• W3033590698 cites W2413888850 @default.
• W3033590698 cites W2510643311 @default.
• W3033590698 cites W2589155514 @default.
• W3033590698 cites W2733307304 @default.
• W3033590698 cites W2735381236 @default.
• W3033590698 cites W2750645423 @default.
• W3033590698 cites W2795773685 @default.
• W3033590698 cites W2796611961 @default.
• W3033590698 cites W2884796678 @default.
• W3033590698 cites W2886790097 @default.
• W3033590698 cites W2889646458 @default.
• W3033590698 cites W2896015292 @default.
• W3033590698 cites W2896668430 @default.
• W3033590698 cites W2898446596 @default.
• W3033590698 cites W2917696006 @default.
• W3033590698 cites W2920580866 @default.
• W3033590698 cites W2946770614 @default.
• W3033590698 cites W2965486449 @default.
• W3033590698 cites W2985194372 @default.
• W3033590698 cites W2985465595 @default.
• W3033590698 cites W2993110724 @default.
• W3033590698 cites W4294215472 @default.
• W3033590698 doi "https://doi.org/10.1016/j.ctim.2020.102472" @default.
• W3033590698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32951722" @default.
• W3033590698 hasPublicationYear "2020" @default.
• W3033590698 type Work @default.
• W3033590698 sameAs 3033590698 @default.
• W3033590698 citedByCount "9" @default.
• W3033590698 countsByYear W30335906982021 @default.
• W3033590698 countsByYear W30335906982022 @default.
• W3033590698 countsByYear W30335906982023 @default.
• W3033590698 crossrefType "journal-article" @default.
• W3033590698 hasAuthorship W3033590698A5008090849 @default.
• W3033590698 hasAuthorship W3033590698A5027607245 @default.
• W3033590698 hasAuthorship W3033590698A5039627897 @default.
• W3033590698 hasAuthorship W3033590698A5043266967 @default.
• W3033590698 hasAuthorship W3033590698A5090952663 @default.
• W3033590698 hasConcept C126322002 @default.
• W3033590698 hasConcept C142724271 @default.
• W3033590698 hasConcept C143998085 @default.
• W3033590698 hasConcept C159110408 @default.
• W3033590698 hasConcept C168563851 @default.
• W3033590698 hasConcept C17744445 @default.
• W3033590698 hasConcept C188947578 @default.
• W3033590698 hasConcept C199539241 @default.
• W3033590698 hasConcept C204787440 @default.
• W3033590698 hasConcept C2776256026 @default.
• W3033590698 hasConcept C2776478404 @default.
• W3033590698 hasConcept C2776694085 @default.
• W3033590698 hasConcept C2779473830 @default.
• W3033590698 hasConcept C2779951463 @default.
• W3033590698 hasConcept C44249647 @default.
• W3033590698 hasConcept C71924100 @default.
• W3033590698 hasConcept C82789193 @default.
• W3033590698 hasConcept C95190672 @default.
• W3033590698 hasConceptScore W3033590698C126322002 @default.
• W3033590698 hasConceptScore W3033590698C142724271 @default.
• W3033590698 hasConceptScore W3033590698C143998085 @default.
• W3033590698 hasConceptScore W3033590698C159110408 @default.
• W3033590698 hasConceptScore W3033590698C168563851 @default.
• W3033590698 hasConceptScore W3033590698C17744445 @default.
• W3033590698 hasConceptScore W3033590698C188947578 @default.
• W3033590698 hasConceptScore W3033590698C199539241 @default.
• W3033590698 hasConceptScore W3033590698C204787440 @default.
• W3033590698 hasConceptScore W3033590698C2776256026 @default.
• W3033590698 hasConceptScore W3033590698C2776478404 @default.
• W3033590698 hasConceptScore W3033590698C2776694085 @default.
• W3033590698 hasConceptScore W3033590698C2779473830 @default.
• W3033590698 hasConceptScore W3033590698C2779951463 @default.
• W3033590698 hasConceptScore W3033590698C44249647 @default.
• W3033590698 hasConceptScore W3033590698C71924100 @default.
• W3033590698 hasConceptScore W3033590698C82789193 @default.
• W3033590698 hasConceptScore W3033590698C95190672 @default.
• W3033590698 hasFunder F4320313619 @default.
• W3033590698 hasLocation W30335906981 @default.

• next