FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033604730> ?p ?o ?g. }

• W3033604730 endingPage "378" @default.
• W3033604730 startingPage "370" @default.
• W3033604730 abstract "Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential preclinical model organisms in neurology and regenerative medicine research. Earlier studies have suggested that the limb regeneration ability of this salamander notably decreases with induction of metamorphosis by thyroid hormones. Metamorphic axolotl requires further validation as a negative control in preclinical regenerative medicine research, not to mention the study of molecular substrates of its regenerative abilities. In this study, we report new observations on the effect of experimentally induced metamorphosis on spinal cord regeneration in axolotl. Surprisingly, we found that metamorphic animals were successful to functionally restore the spinal cord after an experimentally induced injury. To discern the molecular signatures of spinal cord regeneration, we performed transcriptomics analyses at 1- and 7-days postinjury (dpi) for both spinal cord injury (SCI)-induced (experimental) and laminectomy (sham) groups. We observed 119 and 989 differentially expressed genes at 1- and 7-dpi, respectively, while the corresponding mouse orthologous genes were enriched in junction-, immune system-, and extracellular matrix-related pathways. Taken together, our findings challenge the prior notions of limited regenerative ability of metamorphic axolotl which exhibited successful spinal cord regeneration in our experience. Moreover, we report on molecular signatures that can potentially explain the mechanistic substrates of the regenerative capacity of the metamorphic axolotl. To the best of our knowledge, this is the first report on molecular responses to SCI and functional restoration in metamorphic axolotls. These new findings advance our understanding of spinal cord regeneration, and may thus help optimize the future use of axolotl as a preclinical model in regenerative medicine and integrative biology fields." @default.
• W3033604730 created "2020-06-12" @default.
• W3033604730 creator A5001521707 @default.
• W3033604730 creator A5007343951 @default.
• W3033604730 creator A5017317470 @default.
• W3033604730 creator A5042134761 @default.
• W3033604730 creator A5047620766 @default.
• W3033604730 creator A5053788129 @default.
• W3033604730 creator A5056523710 @default.
• W3033604730 date "2020-06-01" @default.
• W3033604730 modified "2023-09-26" @default.
• W3033604730 title "Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (<i>Ambystoma mexicanum</i>) Model in Regenerative Medicine" @default.
• W3033604730 cites W1536345725 @default.
• W3033604730 cites W1595677918 @default.
• W3033604730 cites W1596753747 @default.
• W3033604730 cites W1970970899 @default.
• W3033604730 cites W1973094248 @default.
• W3033604730 cites W1988279940 @default.
• W3033604730 cites W1991466583 @default.
• W3033604730 cites W1999574084 @default.
• W3033604730 cites W2014196270 @default.
• W3033604730 cites W2016854872 @default.
• W3033604730 cites W2029702685 @default.
• W3033604730 cites W2035618305 @default.
• W3033604730 cites W2036897871 @default.
• W3033604730 cites W2052380760 @default.
• W3033604730 cites W2082942199 @default.
• W3033604730 cites W2088633231 @default.
• W3033604730 cites W2100007813 @default.
• W3033604730 cites W2110648073 @default.
• W3033604730 cites W2111605071 @default.
• W3033604730 cites W2114527252 @default.
• W3033604730 cites W2117941971 @default.
• W3033604730 cites W2120220697 @default.
• W3033604730 cites W2126419817 @default.
• W3033604730 cites W2139904607 @default.
• W3033604730 cites W2141224543 @default.
• W3033604730 cites W2143924854 @default.
• W3033604730 cites W2150612768 @default.
• W3033604730 cites W2150947082 @default.
• W3033604730 cites W2155490506 @default.
• W3033604730 cites W2159675211 @default.
• W3033604730 cites W2276788395 @default.
• W3033604730 cites W2465075119 @default.
• W3033604730 cites W2479468016 @default.
• W3033604730 cites W2557436751 @default.
• W3033604730 cites W2763591928 @default.
• W3033604730 cites W2784936077 @default.
• W3033604730 cites W2883510896 @default.
• W3033604730 cites W2886805804 @default.
• W3033604730 cites W2888121578 @default.
• W3033604730 cites W2900402493 @default.
• W3033604730 cites W2900569176 @default.
• W3033604730 cites W2901104860 @default.
• W3033604730 cites W2906992644 @default.
• W3033604730 cites W2958031011 @default.
• W3033604730 cites W2963310322 @default.
• W3033604730 cites W2965241789 @default.
• W3033604730 cites W2989743893 @default.
• W3033604730 doi "https://doi.org/10.1089/omi.2020.0024" @default.
• W3033604730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32496969" @default.
• W3033604730 hasPublicationYear "2020" @default.
• W3033604730 type Work @default.
• W3033604730 sameAs 3033604730 @default.
• W3033604730 citedByCount "6" @default.
• W3033604730 countsByYear W30336047302020 @default.
• W3033604730 countsByYear W30336047302021 @default.
• W3033604730 countsByYear W30336047302022 @default.
• W3033604730 countsByYear W30336047302023 @default.
• W3033604730 crossrefType "journal-article" @default.
• W3033604730 hasAuthorship W3033604730A5001521707 @default.
• W3033604730 hasAuthorship W3033604730A5007343951 @default.
• W3033604730 hasAuthorship W3033604730A5017317470 @default.
• W3033604730 hasAuthorship W3033604730A5042134761 @default.
• W3033604730 hasAuthorship W3033604730A5047620766 @default.
• W3033604730 hasAuthorship W3033604730A5053788129 @default.
• W3033604730 hasAuthorship W3033604730A5056523710 @default.
• W3033604730 hasConcept C105702510 @default.
• W3033604730 hasConcept C10854531 @default.
• W3033604730 hasConcept C136397037 @default.
• W3033604730 hasConcept C169760540 @default.
• W3033604730 hasConcept C171056886 @default.
• W3033604730 hasConcept C173758957 @default.
• W3033604730 hasConcept C2778334475 @default.
• W3033604730 hasConcept C2779945282 @default.
• W3033604730 hasConcept C2780775167 @default.
• W3033604730 hasConcept C28328180 @default.
• W3033604730 hasConcept C2908669727 @default.
• W3033604730 hasConcept C529278444 @default.
• W3033604730 hasConcept C59822182 @default.
• W3033604730 hasConcept C71924100 @default.
• W3033604730 hasConcept C86803240 @default.
• W3033604730 hasConcept C95444343 @default.
• W3033604730 hasConceptScore W3033604730C105702510 @default.
• W3033604730 hasConceptScore W3033604730C10854531 @default.
• W3033604730 hasConceptScore W3033604730C136397037 @default.
• W3033604730 hasConceptScore W3033604730C169760540 @default.
• W3033604730 hasConceptScore W3033604730C171056886 @default.

• next