FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033611127> ?p ?o ?g. }

• W3033611127 endingPage "28013" @default.
• W3033611127 startingPage "28004" @default.
• W3033611127 abstract "Tumor microenvironment (TME)-responsive nanocarrier systems that keep the photosensitizer (PS) inactive during systemic circulation and then efficiently release or activate the PS in response to unique TME conditions have attracted much attention. Herein, we report novel TME-responsive, self-quenched polysaccharide nanoparticles (NPs) with a reactive oxygen species (ROS)-sensitive cascade. The PS, pheophorbide A (PhA), was conjugated to a water-soluble glycol chitosan (GC) through an ROS-sensitive thioketal (TK) linker. The amphiphilic GC-TK-PhA conjugates could arrange themselves into NPs and remain photoinactive due to their self-quenching effects. Upon reaching the ROS-rich hypoxic core of the tumor tissue, the NPs release the PS in a photoactive form by efficient, ROS-sensitive TK bond cleavage, thus generating potent phototoxic effects. Following near-infrared irradiation, the increase in locoregional ROS levels further accelerates the release and activation of PS. These cascade reactions caused a significant reduction in the tumor volume, demonstrating good antitumor potential." @default.
• W3033611127 created "2020-06-12" @default.
• W3033611127 creator A5015625444 @default.
• W3033611127 creator A5053995401 @default.
• W3033611127 creator A5061296132 @default.
• W3033611127 creator A5067418350 @default.
• W3033611127 creator A5073996116 @default.
• W3033611127 creator A5075499419 @default.
• W3033611127 date "2020-06-05" @default.
• W3033611127 modified "2023-10-16" @default.
• W3033611127 title "Self-Quenched Polysaccharide Nanoparticles with a Reactive Oxygen Species-Sensitive Cascade for Enhanced Photodynamic Therapy" @default.
• W3033611127 cites W1992172691 @default.
• W3033611127 cites W2028119065 @default.
• W3033611127 cites W2057602876 @default.
• W3033611127 cites W2124716248 @default.
• W3033611127 cites W2171190698 @default.
• W3033611127 cites W2316841960 @default.
• W3033611127 cites W2552930736 @default.
• W3033611127 cites W2776345905 @default.
• W3033611127 cites W2790757017 @default.
• W3033611127 cites W2806731036 @default.
• W3033611127 cites W2897634419 @default.
• W3033611127 cites W2898015119 @default.
• W3033611127 cites W2898883774 @default.
• W3033611127 cites W2912326420 @default.
• W3033611127 cites W2916203461 @default.
• W3033611127 cites W2922564936 @default.
• W3033611127 cites W2923284444 @default.
• W3033611127 cites W2933595696 @default.
• W3033611127 cites W2941791583 @default.
• W3033611127 cites W2951712229 @default.
• W3033611127 cites W2952125305 @default.
• W3033611127 cites W2968039590 @default.
• W3033611127 cites W2970285711 @default.
• W3033611127 cites W2971448959 @default.
• W3033611127 cites W2973724306 @default.
• W3033611127 cites W2990207795 @default.
• W3033611127 doi "https://doi.org/10.1021/acsami.0c06311" @default.
• W3033611127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32501678" @default.
• W3033611127 hasPublicationYear "2020" @default.
• W3033611127 type Work @default.
• W3033611127 sameAs 3033611127 @default.
• W3033611127 citedByCount "27" @default.
• W3033611127 countsByYear W30336111272020 @default.
• W3033611127 countsByYear W30336111272021 @default.
• W3033611127 countsByYear W30336111272022 @default.
• W3033611127 countsByYear W30336111272023 @default.
• W3033611127 crossrefType "journal-article" @default.
• W3033611127 hasAuthorship W3033611127A5015625444 @default.
• W3033611127 hasAuthorship W3033611127A5053995401 @default.
• W3033611127 hasAuthorship W3033611127A5061296132 @default.
• W3033611127 hasAuthorship W3033611127A5067418350 @default.
• W3033611127 hasAuthorship W3033611127A5073996116 @default.
• W3033611127 hasAuthorship W3033611127A5075499419 @default.
• W3033611127 hasConcept C127413603 @default.
• W3033611127 hasConcept C155672457 @default.
• W3033611127 hasConcept C171250308 @default.
• W3033611127 hasConcept C178790620 @default.
• W3033611127 hasConcept C185592680 @default.
• W3033611127 hasConcept C192562407 @default.
• W3033611127 hasConcept C2781323092 @default.
• W3033611127 hasConcept C34146451 @default.
• W3033611127 hasConcept C42360764 @default.
• W3033611127 hasConcept C48349386 @default.
• W3033611127 hasConcept C540031477 @default.
• W3033611127 hasConcept C55493867 @default.
• W3033611127 hasConcept C75473681 @default.
• W3033611127 hasConceptScore W3033611127C127413603 @default.
• W3033611127 hasConceptScore W3033611127C155672457 @default.
• W3033611127 hasConceptScore W3033611127C171250308 @default.
• W3033611127 hasConceptScore W3033611127C178790620 @default.
• W3033611127 hasConceptScore W3033611127C185592680 @default.
• W3033611127 hasConceptScore W3033611127C192562407 @default.
• W3033611127 hasConceptScore W3033611127C2781323092 @default.
• W3033611127 hasConceptScore W3033611127C34146451 @default.
• W3033611127 hasConceptScore W3033611127C42360764 @default.
• W3033611127 hasConceptScore W3033611127C48349386 @default.
• W3033611127 hasConceptScore W3033611127C540031477 @default.
• W3033611127 hasConceptScore W3033611127C55493867 @default.
• W3033611127 hasConceptScore W3033611127C75473681 @default.
• W3033611127 hasFunder F4320321681 @default.
• W3033611127 hasFunder F4320322120 @default.
• W3033611127 hasIssue "25" @default.
• W3033611127 hasLocation W30336111271 @default.
• W3033611127 hasOpenAccess W3033611127 @default.
• W3033611127 hasPrimaryLocation W30336111271 @default.
• W3033611127 hasRelatedWork W2006043039 @default.
• W3033611127 hasRelatedWork W2027454142 @default.
• W3033611127 hasRelatedWork W2057364330 @default.
• W3033611127 hasRelatedWork W2070391038 @default.
• W3033611127 hasRelatedWork W2169492644 @default.
• W3033611127 hasRelatedWork W2333295409 @default.
• W3033611127 hasRelatedWork W2547917240 @default.
• W3033611127 hasRelatedWork W2808489470 @default.
• W3033611127 hasRelatedWork W3082923381 @default.
• W3033611127 hasRelatedWork W3216624863 @default.
• W3033611127 hasVolume "12" @default.
• W3033611127 isParatext "false" @default.

• next