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• W3033621030 abstract "Abstract Background Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to migraine had not been well elucidated. Thus, the present study investigated vestibular dysfunction in a rat model of chronic migraine (CM), and to dissect potential mechanisms between migraine and vertigo. Methods Rats subjected to recurrent intermittent administration of nitroglycerin (NTG) were used as the CM model. Migraine- and vestibular-related behaviors were analyzed. Immunofluorescent analyses and quantitative real-time polymerase chain reaction were employed to detect expressions of c-fos and calcitonin gene-related peptide (CGRP) in the trigeminal nucleus caudalis (TNC) and vestibular nucleus (VN). Morphological changes of vestibular afferent terminals was determined under transmission electron microscopy. FluoroGold (FG) and CTB-555 were selected as retrograde tracers and injected into the VN and TNC, respectively. Lentiviral vectors comprising CGRP short hairpin RNA (LV-CGRP) was injected into the trigeminal ganglion. Results CM led to persistent thermal hyperalgesia, spontaneous facial pain, and prominent vestibular dysfunction, accompanied by the upregulation of c-fos labeling neurons and CGRP immunoreactivity in the TNC (c-fos: vehicle vs. CM = 2.9 ± 0.6 vs. 45.5 ± 3.4; CGRP OD: vehicle vs. CM = 0.1 ± 0.0 vs. 0.2 ± 0.0) and VN (c-fos: vehicle vs. CM = 2.3 ± 0.8 vs. 54.0 ± 2.1; CGRP mRNA: vehicle vs. CM = 1.0 ± 0.1 vs. 2.4 ± 0.1). Furthermore, FG-positive neurons was accumulated in the superficial layer of the TNC, and the number of c-fos+/FG+ neurons were significantly increased in rats with CM compared to the vehicle group (vehicle vs. CM = 25.3 ± 2.2 vs. 83.9 ± 3.0). Meanwhile, CTB-555+ neurons dispersed throughout the VN. The structure of vestibular afferent terminals was less pronounced after CM compared with the peripheral vestibular dysfunction model. In vivo knockdown of CGRP in the trigeminal ganglion significantly reduced the number of c-fos labeling neurons (LV-CGRP vs. LV-NC = 9.9 ± 3.0 vs. 60.0 ± 4.5) and CGRP mRNA (LV-CGRP vs. LV-NC = 1.0 ± 0.1 vs. 2.1 ± 0.2) in the VN, further attenuating vestibular dysfunction after CM. Conclusions These data demonstrates the possibility of sensitization of vestibular nucleus neurons to impair vestibular function after CM, and anti-CGRP treatment to restore vestibular dysfunction in patients with CM." @default.
• W3033621030 created "2020-06-12" @default.
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• W3033621030 date "2020-06-10" @default.
• W3033621030 modified "2023-10-05" @default.
• W3033621030 title "Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine" @default.
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• W3033621030 cites W1965790846 @default.
• W3033621030 cites W1966087930 @default.
• W3033621030 cites W1976359020 @default.
• W3033621030 cites W1977091143 @default.
• W3033621030 cites W1977551632 @default.
• W3033621030 cites W1984050552 @default.
• W3033621030 cites W1991542851 @default.
• W3033621030 cites W1997452544 @default.
• W3033621030 cites W2009439698 @default.
• W3033621030 cites W2014007136 @default.
• W3033621030 cites W2018517008 @default.
• W3033621030 cites W2019670494 @default.
• W3033621030 cites W2021766128 @default.
• W3033621030 cites W2030204595 @default.
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• W3033621030 cites W2052083400 @default.
• W3033621030 cites W2052847716 @default.
• W3033621030 cites W2061617105 @default.
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• W3033621030 cites W2085642595 @default.
• W3033621030 cites W2086875921 @default.
• W3033621030 cites W2091263881 @default.
• W3033621030 cites W2096918030 @default.
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• W3033621030 cites W2116230226 @default.
• W3033621030 cites W2117689825 @default.
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• W3033621030 cites W2586533881 @default.
• W3033621030 cites W2752641243 @default.
• W3033621030 cites W2760901533 @default.
• W3033621030 cites W2765205762 @default.
• W3033621030 cites W2786493955 @default.
• W3033621030 cites W2787852154 @default.
• W3033621030 cites W2797436211 @default.
• W3033621030 cites W2800530307 @default.
• W3033621030 cites W2801085490 @default.
• W3033621030 cites W2803505359 @default.
• W3033621030 cites W2895868360 @default.
• W3033621030 cites W2914307124 @default.
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• W3033621030 doi "https://doi.org/10.1186/s10194-020-01145-y" @default.
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