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- W3033621808 abstract "The extremophile environment and its microbes have provided access to numerous bioactive secondary metabolites but it is still not fully exploited due to the difficulty for their extreme nature in under laboratory conditions. Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Cultured minority of microbes are collectively believed to contain large number biosynthetic gene clusters that have never been examined for their ability to produce clinically and industrially important natural bioactive secondary metabolites from microbes. Community metagenomics study also proves the dominating characteristics of sulfur- and nitrogen-cycling genes in the extremophiles. Molecular phylogenetic-type analysis to biosynthesis gene diversity of extremophile environment provides a better understanding of the richness of this hidden biosynthetic reservoir with the discovery of additional novel bioactive natural products. In this chapter, we shall try to summarize the protein adaptations of extremophiles, their industrial and biotechnological use." @default.
- W3033621808 created "2020-06-12" @default.
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- W3033621808 date "2020-01-01" @default.
- W3033621808 modified "2023-09-24" @default.
- W3033621808 title "Exploration of extremophiles genomes through gene study for hidden biotechnological and future potential" @default.
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- W3033621808 doi "https://doi.org/10.1016/b978-0-12-818322-9.00024-1" @default.
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