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- W30336310 abstract "Heterogeneity in circulating HDL-cholesterol concentrations in response to dietary fat intake may be due, in part, to genetic variations in the hepatic lipase (HL) gene. A polymorphism in the HL gene (−514C>T) has been shown to modify the effect of dietary fat on circulating HDL-cholesterol concentrations in some cohort studies, but the effects have not been consistent. We investigated the gene-diet interaction in a population of Canadian individuals with type 2 diabetes. Subjects (n=109) recruited were type 2 diabetic men (n=53) and women (n=56) aged 42–75 years. Blood samples were collected to determine fasting plasma lipid levels and genotyping was performed by PCR-RFLP. An analysis of covariance was performed for age, sex, BMI and alcohol intake. We found an interaction between the HL −514C>T polymorphism and intakes of total fat (p=0.005), saturated fat (p=0.02), and monounsaturated fat (p= 0.01), but not polyunsaturated fat (p= 0.10) on serum HDL-cholesterol. Energy from total fat intake was inversely associated with serum HDL-cholesterol for individuals with the T allele (regression coefficient β =−0.02±0.01 mmol/l /1% energy from fat; p=0.007), but not among those with the CC genotype (p=0.31) (p for interaction =0.005). All interactions were observed among non-obese, but not obese individuals. In summary, the HL −514 C>T polymorphism modifies the association between dietary fat intake and serum HDL-cholesterol in non-obese individuals with type 2 diabetes. Supported by CIHR (MCT-44205)." @default.
- W30336310 created "2016-06-24" @default.
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- W30336310 date "2007-01-01" @default.
- W30336310 modified "2023-10-15" @default.
- W30336310 title "Hepatic Lipase ‐514C>T Polymorphism Modifies the Association between Dietary Fat Intake and Fasting Levels of HDL‐cholesterol in Individuals with Type 2 Diabetes" @default.
- W30336310 doi "https://doi.org/10.1096/fasebj.21.6.a1105-b" @default.
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