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• W3033655077 abstract "Abstract Much microbiome research has focused on populations that are predominantly of European descent, and from narrow demographics that do not capture the socio-economic and lifestyle differences which impact human health. Here we examined the airway microbiomes of the Orang Asli, the indigenous peoples of Malaysia. A total of 130 participants were recruited from two sites in the north-eastern state of Terengganu in Peninsular Malaysia. Using 16S rRNA sequencing, the nasal microbiome was significantly more diverse in those aged 5–17 years compared to 50+ years ( p = 0.023) and clustered by age (PERMANOVA analysis of the Bray–Curtis distance, p = 0.001). Hierarchical clustering of Bray–Curtis dissimilarity scores revealed six microbiome clusters. The largest cluster ( n = 28; 35.4%) had a marked abundance of Corynebacterium . In the oral microbiomes Streptococcus , Neisseria and Haemophilus were dominant. Using conventional microbiology, high levels of Staphylococcus aureus carriage were observed, particularly in the 18–65 age group ( n = 17/36; 47.2% 95% CI: 30.9–63.5). The highest carriage of pneumococci was in the <5 and 5 to 17 year olds, with 57.1% (4/7) and 49.2% (30/61), respectively. Sixteen pneumococcal serotypes were identified, the most common being the nonvaccine-type 23A (14.6%) and the vaccine-type 6B (9.8%). The prevalence of pneumococcal serotypes covered by pneumococcal conjugate vaccines support introduction into a Malaysian national immunisation schedule. In addition, the dominance of Corynebacterium in the airway microbiomes is intriguing given their role as a potentially protective commensal with respect to acute infection and respiratory health." @default.
• W3033655077 created "2020-06-12" @default.
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• W3033655077 date "2021-01-05" @default.
• W3033655077 modified "2023-10-10" @default.
• W3033655077 title "The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia" @default.
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• W3033655077 doi "https://doi.org/10.1038/s41522-020-00173-5" @default.
• W3033655077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7785749" @default.
• W3033655077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33402693" @default.
• W3033655077 hasPublicationYear "2021" @default.
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