FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033684673> ?p ?o ?g. }

• W3033684673 endingPage "1388" @default.
• W3033684673 startingPage "1388" @default.
• W3033684673 abstract "Glycogen synthase kinase (GSK)3β is a multifunctional serine/threonine protein kinase with more than 100 substrates and interacting molecules. GSK3β is normally active in cells and negative regulation of GSK3β activity via phosphorylation of its serine 9 residue is required for most normal cells to maintain homeostasis. Aberrant expression and activity of GSK3β contributes to the pathogenesis and progression of common recalcitrant diseases such as glucose intolerance, neurodegenerative disorders and cancer. Despite recognized roles against several proto-oncoproteins and mediators of the epithelial–mesenchymal transition, deregulated GSK3β also participates in tumor cell survival, evasion of apoptosis, proliferation and invasion, as well as sustaining cancer stemness and inducing therapy resistance. A therapeutic effect from GSK3β inhibition has been demonstrated in 25 different cancer types. Moreover, there is increasing evidence that GSK3β inhibition protects normal cells and tissues from the harmful effects associated with conventional cancer therapies. Here, we review the evidence supporting aberrant GSK3β as a hallmark property of cancer and highlight the beneficial effects of GSK3β inhibition on normal cells and tissues during cancer therapy. The biological rationale for targeting GSK3β in the treatment of cancer is also discussed at length." @default.
• W3033684673 created "2020-06-12" @default.
• W3033684673 creator A5032836340 @default.
• W3033684673 creator A5053435190 @default.
• W3033684673 creator A5058032939 @default.
• W3033684673 creator A5085347834 @default.
• W3033684673 date "2020-06-03" @default.
• W3033684673 modified "2023-10-03" @default.
• W3033684673 title "Glycogen Synthase Kinase 3β in Cancer Biology and Treatment" @default.
• W3033684673 cites W1246025851 @default.
• W3033684673 cites W1487499403 @default.
• W3033684673 cites W1499904920 @default.
• W3033684673 cites W1531311621 @default.
• W3033684673 cites W1549571859 @default.
• W3033684673 cites W1550516490 @default.
• W3033684673 cites W1564515478 @default.
• W3033684673 cites W1568081373 @default.
• W3033684673 cites W1573065398 @default.
• W3033684673 cites W1581943791 @default.
• W3033684673 cites W1634699770 @default.
• W3033684673 cites W1674676341 @default.
• W3033684673 cites W1716978847 @default.
• W3033684673 cites W1755723233 @default.
• W3033684673 cites W1842457464 @default.
• W3033684673 cites W1860297623 @default.
• W3033684673 cites W1894832831 @default.
• W3033684673 cites W1950105649 @default.
• W3033684673 cites W1953029315 @default.
• W3033684673 cites W1964632863 @default.
• W3033684673 cites W1968904120 @default.
• W3033684673 cites W1971669672 @default.
• W3033684673 cites W1971714772 @default.
• W3033684673 cites W1972019822 @default.
• W3033684673 cites W1974110134 @default.
• W3033684673 cites W1976153058 @default.
• W3033684673 cites W1977195675 @default.
• W3033684673 cites W1977455716 @default.
• W3033684673 cites W1978714931 @default.
• W3033684673 cites W1979602806 @default.
• W3033684673 cites W1979700215 @default.
• W3033684673 cites W1980088710 @default.
• W3033684673 cites W1980195727 @default.
• W3033684673 cites W1981824665 @default.
• W3033684673 cites W1988428451 @default.
• W3033684673 cites W1988623463 @default.
• W3033684673 cites W1989168656 @default.
• W3033684673 cites W1989304353 @default.
• W3033684673 cites W1989548729 @default.
• W3033684673 cites W1990201193 @default.
• W3033684673 cites W1991433778 @default.
• W3033684673 cites W1991959472 @default.
• W3033684673 cites W1992861698 @default.
• W3033684673 cites W1994994301 @default.
• W3033684673 cites W1995284165 @default.
• W3033684673 cites W1995945309 @default.
• W3033684673 cites W1997224330 @default.
• W3033684673 cites W1997229505 @default.
• W3033684673 cites W1997546539 @default.
• W3033684673 cites W1999876234 @default.
• W3033684673 cites W2000324903 @default.
• W3033684673 cites W2001573731 @default.
• W3033684673 cites W2002216151 @default.
• W3033684673 cites W2002564957 @default.
• W3033684673 cites W2003799931 @default.
• W3033684673 cites W2006964316 @default.
• W3033684673 cites W2007241783 @default.
• W3033684673 cites W2009046911 @default.
• W3033684673 cites W2009555189 @default.
• W3033684673 cites W2010119111 @default.
• W3033684673 cites W2010657606 @default.
• W3033684673 cites W2011401291 @default.
• W3033684673 cites W2012868552 @default.
• W3033684673 cites W2013800509 @default.
• W3033684673 cites W2014623749 @default.
• W3033684673 cites W2017818235 @default.
• W3033684673 cites W2019196925 @default.
• W3033684673 cites W2021174770 @default.
• W3033684673 cites W2021499671 @default.
• W3033684673 cites W2021953628 @default.
• W3033684673 cites W2028295337 @default.
• W3033684673 cites W2031607563 @default.
• W3033684673 cites W2032506765 @default.
• W3033684673 cites W2033830808 @default.
• W3033684673 cites W2034143104 @default.
• W3033684673 cites W2034459983 @default.
• W3033684673 cites W2035376760 @default.
• W3033684673 cites W2035705797 @default.
• W3033684673 cites W2035827704 @default.
• W3033684673 cites W2036619542 @default.
• W3033684673 cites W2036978461 @default.
• W3033684673 cites W2039816570 @default.
• W3033684673 cites W2041277465 @default.
• W3033684673 cites W2041353769 @default.
• W3033684673 cites W2042619042 @default.
• W3033684673 cites W2043474049 @default.
• W3033684673 cites W2043650993 @default.
• W3033684673 cites W2046464769 @default.
• W3033684673 cites W2046815613 @default.

• next