FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033700536> ?p ?o ?g. }

• W3033700536 endingPage "100089" @default.
• W3033700536 startingPage "100089" @default.
• W3033700536 abstract "Noise, a disturbing and unwanted sound is currently being perceived as a widespread environmental stressor. In the present study we investigated the activation of oxidative stress as a mechanism involved in cognitive impairment through changes in neuro-inflammation. Sprague Dawley rats (200-220 ​ ​g ​m) were exposed to moderate (100dB) sound pressure level (SPL) noise daily for 2 ​h ​s over a period of 15 and 30 days and the consequence on brain regions of hippocampus observed through behavioral studies by Morris Water Maze to assess effects on spatial memory coupled with biochemical evaluation of markers of oxidative stress and inflammation. Further, the underlying mechanism pertaining to apoptosis was investigated by immuno-histological studies through assessment of Caspase-3 and TUNEL assay as well as morphological parameters, namely Nissl bodies in CA1, CA3 and DG regions of hippocampus. Poorer performance in the MWM indicative of decrement in concept formation, attention, working memory, and reference memory was observed on 15 and 30 days of noise exposures. At the cellular level, increased oxidative stress and inflammation was noticed as evinced by elevated levels of TNF-α, IL-6, IL-1α and IFN-γ in both hippocampus and plasma. Exposure to noise also led to a gradual increase in the number of pyknotic and apoptotic neurons together with the increase in DNA fragmentation in hippocampus. Increased levels of inflammatory genes (i.g.) ccl2, ccr5, ifng, il13, il1a, tnfa coupled with decreased levels of bmp2 and il3 genes were found in both the noise exposure groups. Our findings revealed that moderate intensity noise exposure impaired early memory changes in expression of several gene families including genes associated with regulation of transcription, inflammatory response, and, response to oxidative stress." @default.
• W3033700536 created "2020-06-12" @default.
• W3033700536 creator A5006198090 @default.
• W3033700536 creator A5007477235 @default.
• W3033700536 creator A5018082801 @default.
• W3033700536 creator A5028122689 @default.
• W3033700536 creator A5081038717 @default.
• W3033700536 date "2020-05-01" @default.
• W3033700536 modified "2023-09-23" @default.
• W3033700536 title "Moderate noise associated oxidative stress with concomitant memory impairment, neuro-inflammation and neurodegeneration" @default.
• W3033700536 cites W104892186 @default.
• W3033700536 cites W1085403008 @default.
• W3033700536 cites W1492728201 @default.
• W3033700536 cites W1970757672 @default.
• W3033700536 cites W1977956790 @default.
• W3033700536 cites W1980524078 @default.
• W3033700536 cites W1980662526 @default.
• W3033700536 cites W1981377196 @default.
• W3033700536 cites W1988635850 @default.
• W3033700536 cites W1998878650 @default.
• W3033700536 cites W2007618030 @default.
• W3033700536 cites W2009291568 @default.
• W3033700536 cites W2013333685 @default.
• W3033700536 cites W2017169966 @default.
• W3033700536 cites W2022443561 @default.
• W3033700536 cites W2025084107 @default.
• W3033700536 cites W2036790169 @default.
• W3033700536 cites W2047860183 @default.
• W3033700536 cites W2049167261 @default.
• W3033700536 cites W2050138498 @default.
• W3033700536 cites W2070447896 @default.
• W3033700536 cites W2072267350 @default.
• W3033700536 cites W2091237743 @default.
• W3033700536 cites W2111354263 @default.
• W3033700536 cites W2111964682 @default.
• W3033700536 cites W2120495407 @default.
• W3033700536 cites W2120666984 @default.
• W3033700536 cites W2121966499 @default.
• W3033700536 cites W2158553737 @default.
• W3033700536 cites W2172147964 @default.
• W3033700536 cites W2344245973 @default.
• W3033700536 cites W2820111490 @default.
• W3033700536 cites W2884834704 @default.
• W3033700536 cites W2912165760 @default.
• W3033700536 doi "https://doi.org/10.1016/j.bbih.2020.100089" @default.
• W3033700536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8474184" @default.
• W3033700536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34589861" @default.
• W3033700536 hasPublicationYear "2020" @default.
• W3033700536 type Work @default.
• W3033700536 sameAs 3033700536 @default.
• W3033700536 citedByCount "4" @default.
• W3033700536 countsByYear W30337005362020 @default.
• W3033700536 countsByYear W30337005362022 @default.
• W3033700536 countsByYear W30337005362023 @default.
• W3033700536 crossrefType "journal-article" @default.
• W3033700536 hasAuthorship W3033700536A5006198090 @default.
• W3033700536 hasAuthorship W3033700536A5007477235 @default.
• W3033700536 hasAuthorship W3033700536A5018082801 @default.
• W3033700536 hasAuthorship W3033700536A5028122689 @default.
• W3033700536 hasAuthorship W3033700536A5081038717 @default.
• W3033700536 hasBestOaLocation W30337005361 @default.
• W3033700536 hasConcept C126322002 @default.
• W3033700536 hasConcept C134018914 @default.
• W3033700536 hasConcept C169760540 @default.
• W3033700536 hasConcept C169900460 @default.
• W3033700536 hasConcept C196795494 @default.
• W3033700536 hasConcept C204232928 @default.
• W3033700536 hasConcept C2776151105 @default.
• W3033700536 hasConcept C2776914184 @default.
• W3033700536 hasConcept C2776925932 @default.
• W3033700536 hasConcept C2779134260 @default.
• W3033700536 hasConcept C2781161787 @default.
• W3033700536 hasConcept C3018842126 @default.
• W3033700536 hasConcept C44752575 @default.
• W3033700536 hasConcept C71924100 @default.
• W3033700536 hasConcept C86803240 @default.
• W3033700536 hasConceptScore W3033700536C126322002 @default.
• W3033700536 hasConceptScore W3033700536C134018914 @default.
• W3033700536 hasConceptScore W3033700536C169760540 @default.
• W3033700536 hasConceptScore W3033700536C169900460 @default.
• W3033700536 hasConceptScore W3033700536C196795494 @default.
• W3033700536 hasConceptScore W3033700536C204232928 @default.
• W3033700536 hasConceptScore W3033700536C2776151105 @default.
• W3033700536 hasConceptScore W3033700536C2776914184 @default.
• W3033700536 hasConceptScore W3033700536C2776925932 @default.
• W3033700536 hasConceptScore W3033700536C2779134260 @default.
• W3033700536 hasConceptScore W3033700536C2781161787 @default.
• W3033700536 hasConceptScore W3033700536C3018842126 @default.
• W3033700536 hasConceptScore W3033700536C44752575 @default.
• W3033700536 hasConceptScore W3033700536C71924100 @default.
• W3033700536 hasConceptScore W3033700536C86803240 @default.
• W3033700536 hasFunder F4320321024 @default.
• W3033700536 hasLocation W30337005361 @default.
• W3033700536 hasLocation W30337005362 @default.
• W3033700536 hasLocation W30337005363 @default.
• W3033700536 hasOpenAccess W3033700536 @default.
• W3033700536 hasPrimaryLocation W30337005361 @default.
• W3033700536 hasRelatedWork W2055723753 @default.

• next