Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033710822> ?p ?o ?g. }
- W3033710822 abstract "Abstract Fear, anxiety, and trauma-related disorders, including post-traumatic stress disorder (PTSD), are quite common and debilitating, with an estimated lifetime prevalence of ~28% in Western populations. They are associated with excessive fear reactions, often including an inability to extinguish learned fear, increased avoidance behavior, as well as altered cognition and mood. There is an extensive literature demonstrating the importance of N- methyl- d -aspartate receptor (NMDAR) function in regulating these behaviors. NMDARs require the binding of a co-agonist, d -serine or glycine, at the glycine modulatory site (GMS) to function. d -serine is now garnering attention as the primary NMDAR co-agonist in limbic brain regions implicated in neuropsychiatric disorders. l -serine is synthesized by astrocytes, which is then transported to neurons for conversion to d -serine by serine racemase (SR), a model we term the ‘serine shuttle.’ The neuronally-released d -serine is what regulates NMDAR activity. Our review discusses how the systems that regulate the synaptic availability of d -serine, a critical gatekeeper of NMDAR-dependent activation, could be targeted to improve the pharmacologic management of anxiety-related disorders where the desired outcomes are the facilitation of fear extinction, as well as mood and cognitive enhancement." @default.
- W3033710822 created "2020-06-12" @default.
- W3033710822 creator A5005170631 @default.
- W3033710822 creator A5051690277 @default.
- W3033710822 date "2020-06-09" @default.
- W3033710822 modified "2023-10-06" @default.
- W3033710822 title "d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders" @default.
- W3033710822 cites W1506410119 @default.
- W3033710822 cites W1547865271 @default.
- W3033710822 cites W1763274674 @default.
- W3033710822 cites W1780722919 @default.
- W3033710822 cites W1797368996 @default.
- W3033710822 cites W1833075442 @default.
- W3033710822 cites W1917239456 @default.
- W3033710822 cites W1946000001 @default.
- W3033710822 cites W1972018788 @default.
- W3033710822 cites W1972434093 @default.
- W3033710822 cites W1977502547 @default.
- W3033710822 cites W1977923848 @default.
- W3033710822 cites W1978489779 @default.
- W3033710822 cites W1979751654 @default.
- W3033710822 cites W1986110171 @default.
- W3033710822 cites W1989045560 @default.
- W3033710822 cites W1989317045 @default.
- W3033710822 cites W1989982790 @default.
- W3033710822 cites W1996045753 @default.
- W3033710822 cites W1997566439 @default.
- W3033710822 cites W2000924162 @default.
- W3033710822 cites W2002360316 @default.
- W3033710822 cites W2002672156 @default.
- W3033710822 cites W2010158663 @default.
- W3033710822 cites W2025360676 @default.
- W3033710822 cites W2026096441 @default.
- W3033710822 cites W2026836897 @default.
- W3033710822 cites W2031636627 @default.
- W3033710822 cites W2036796078 @default.
- W3033710822 cites W2039872800 @default.
- W3033710822 cites W2040394639 @default.
- W3033710822 cites W2040549344 @default.
- W3033710822 cites W2041620154 @default.
- W3033710822 cites W2046222481 @default.
- W3033710822 cites W2047534429 @default.
- W3033710822 cites W2048181000 @default.
- W3033710822 cites W2049460016 @default.
- W3033710822 cites W2049812132 @default.
- W3033710822 cites W2051145567 @default.
- W3033710822 cites W2051513718 @default.
- W3033710822 cites W2052093136 @default.
- W3033710822 cites W2053273968 @default.
- W3033710822 cites W2054939283 @default.
- W3033710822 cites W2055042327 @default.
- W3033710822 cites W2055652253 @default.
- W3033710822 cites W2056734208 @default.
- W3033710822 cites W2062772815 @default.
- W3033710822 cites W2062959060 @default.
- W3033710822 cites W2065483210 @default.
- W3033710822 cites W2071802266 @default.
- W3033710822 cites W2076425653 @default.
- W3033710822 cites W2076923795 @default.
- W3033710822 cites W2077466797 @default.
- W3033710822 cites W2078096392 @default.
- W3033710822 cites W2080357839 @default.
- W3033710822 cites W2081273690 @default.
- W3033710822 cites W2081499611 @default.
- W3033710822 cites W2081678712 @default.
- W3033710822 cites W2081999660 @default.
- W3033710822 cites W2082548493 @default.
- W3033710822 cites W2084026457 @default.
- W3033710822 cites W2087940090 @default.
- W3033710822 cites W2088638836 @default.
- W3033710822 cites W2090389523 @default.
- W3033710822 cites W2091429488 @default.
- W3033710822 cites W2092481091 @default.
- W3033710822 cites W2100590082 @default.
- W3033710822 cites W2103881507 @default.
- W3033710822 cites W2104613739 @default.
- W3033710822 cites W2108175286 @default.
- W3033710822 cites W2108961156 @default.
- W3033710822 cites W2109167188 @default.
- W3033710822 cites W2109805561 @default.
- W3033710822 cites W2109807917 @default.
- W3033710822 cites W2109909801 @default.
- W3033710822 cites W2110787178 @default.
- W3033710822 cites W2113485684 @default.
- W3033710822 cites W2118826874 @default.
- W3033710822 cites W2120714531 @default.
- W3033710822 cites W2123090955 @default.
- W3033710822 cites W2124556602 @default.
- W3033710822 cites W2128762670 @default.
- W3033710822 cites W2130838343 @default.
- W3033710822 cites W2135743854 @default.
- W3033710822 cites W2135772494 @default.
- W3033710822 cites W2137004537 @default.
- W3033710822 cites W2140807764 @default.
- W3033710822 cites W2141196156 @default.
- W3033710822 cites W2141412827 @default.
- W3033710822 cites W2146741375 @default.
- W3033710822 cites W2147808921 @default.
- W3033710822 cites W2149932734 @default.
- W3033710822 cites W2150417149 @default.