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• W3033737500 endingPage "108744" @default.
• W3033737500 startingPage "108744" @default.
• W3033737500 abstract "Porcine reproductive and respiratory syndrome virus (PRRSV) plays a key role in porcine respiratory disease complex modulating the host immune response and favouring secondary bacterial infections. Pulmonary alveolar macrophages (PAMs) are the main cells supporting PRRSV replication, with CD163 as the essential receptor for viral infection. Although interstitial pneumonia is by far the representative lung lesion, suppurative bronchopneumonia is described for PRRSV virulent strains. This research explores the role of several immune markers potentially involved in the regulation of the inflammatory response and sensitisation of lung to secondary bacterial infections by PRRSV-1 strains of different virulence. Conventional pigs were intranasally inoculated with the virulent subtype 3 Lena strain or the low virulent subtype 1 3249 strain and euthanised at 1, 3, 6 and 8 dpi. Lena-infected pigs exhibited more severe clinical signs, macroscopic lung score and viraemia associated with an increase of IL-6 and IFN-γ in sera compared to 3249-infected pigs. Extensive areas of lung consolidation corresponding with suppurative bronchopneumonia were observed in Lena-infected pigs. Lung viral load and PRRSV-N-protein+ cells were always higher in Lena-infected animals. PRRSV-N-protein+ cells were linked to a marked drop of CD163+ macrophages. The number of CD14+ and iNOS+ cells gradually increased along PRRSV-1 infection, being more evident in Lena-infected pigs. The frequency of CD200R1+ and FoxP3+ cells peaked late in both PRRSV-1 strains, with a strong correlation between CD200R1+ cells and lung injury in Lena-infected pigs. These results highlight the role of molecules involved in the earlier and higher extent of lung lesions in piglets infected with the virulent Lena strain, pointing out the activation of routes potentially involved in the restraint of the local inflammatory response." @default.
• W3033737500 created "2020-06-12" @default.
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• W3033737500 date "2020-07-01" @default.
• W3033737500 modified "2023-10-14" @default.
• W3033737500 title "Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena" @default.
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• W3033737500 doi "https://doi.org/10.1016/j.vetmic.2020.108744" @default.
• W3033737500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7265841" @default.
• W3033737500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32605751" @default.
• W3033737500 hasPublicationYear "2020" @default.
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• W3033737500 hasAuthorship W3033737500A5000618929 @default.
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