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- W3033804924 abstract "Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG form a belt that demarcates lesioned from intact white matter. Mice with selective inactivation of Ndst1 in the OLG lineage display increased lesion size, sustained microglia and OPC reactivity. HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrichment of this morphogen involved in myelin regeneration. In MS patients, Ndst1 is also found overexpressed in oligodendroglia and the number of Ndst1-expressing oligodendroglia is inversely correlated with lesion size and positively correlated with remyelination potential. Our study suggests that mature OLG surrounding demyelinated lesions are not passive witnesses but contribute to protection and regeneration by producing HS." @default.
- W3033804924 created "2020-06-12" @default.
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- W3033804924 date "2020-06-09" @default.
- W3033804924 modified "2023-10-03" @default.
- W3033804924 title "Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production" @default.
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- W3033804924 doi "https://doi.org/10.7554/elife.51735" @default.
- W3033804924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7308090" @default.
- W3033804924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32515730" @default.
- W3033804924 hasPublicationYear "2020" @default.
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