Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033823508> ?p ?o ?g. }
- W3033823508 endingPage "298" @default.
- W3033823508 startingPage "298" @default.
- W3033823508 abstract "Polar marine ecosystems hold the potential for bioactive compound biodiscovery, based on their untapped macro- and microorganism diversity. Characterization of polar benthic marine invertebrate-associated microbiomes is limited to few studies. This study was motivated by our interest in better understanding the microbiome structure and composition of the ascidian, Synoicum adareanum, in which palmerolide A (PalA), a bioactive macrolide with specificity against melanoma, was isolated. PalA bears structural resemblance to a hybrid nonribosomal peptide-polyketide that has similarities to microbially-produced macrolides. We conducted a spatial survey to assess both PalA levels and microbiome composition in S. adareanum in a region of the Antarctic Peninsula near Anvers Island (64°46′ S, 64°03′ W). PalA was ubiquitous and abundant across a collection of 21 ascidians (3 subsamples each) sampled from seven sites across the Anvers Island Archipelago. The microbiome composition (V3–V4 16S rRNA gene sequence variants) of these 63 samples revealed a core suite of 21 bacterial amplicon sequence variants (ASVs)—20 of which were distinct from regional bacterioplankton. ASV co-occurrence analysis across all 63 samples yielded subgroups of taxa that may be interacting biologically (interacting subsystems) and, although the levels of PalA detected were not found to correlate with specific sequence variants, the core members appeared to occur in a preferred optimum and tolerance range of PalA levels. These results, together with an analysis of the biosynthetic potential of related microbiome taxa, describe a conserved, high-latitude core microbiome with unique composition and substantial promise for natural product biosynthesis that likely influences the ecology of the holobiont." @default.
- W3033823508 created "2020-06-12" @default.
- W3033823508 creator A5006014190 @default.
- W3033823508 creator A5012567626 @default.
- W3033823508 creator A5044888119 @default.
- W3033823508 creator A5055420267 @default.
- W3033823508 creator A5055512390 @default.
- W3033823508 creator A5063824632 @default.
- W3033823508 creator A5069231615 @default.
- W3033823508 creator A5069453413 @default.
- W3033823508 creator A5073335661 @default.
- W3033823508 creator A5075136369 @default.
- W3033823508 creator A5077072391 @default.
- W3033823508 creator A5078081186 @default.
- W3033823508 creator A5081988322 @default.
- W3033823508 creator A5085204682 @default.
- W3033823508 date "2020-06-02" @default.
- W3033823508 modified "2023-10-10" @default.
- W3033823508 title "Uncovering the Core Microbiome and Distribution of Palmerolide in Synoicum adareanum Across the Anvers Island Archipelago, Antarctica" @default.
- W3033823508 cites W1561814691 @default.
- W3033823508 cites W1914920873 @default.
- W3033823508 cites W1966327575 @default.
- W3033823508 cites W1974880412 @default.
- W3033823508 cites W1976578940 @default.
- W3033823508 cites W1980824875 @default.
- W3033823508 cites W1986803907 @default.
- W3033823508 cites W1987246007 @default.
- W3033823508 cites W1994582862 @default.
- W3033823508 cites W1997417897 @default.
- W3033823508 cites W1998292935 @default.
- W3033823508 cites W2009231348 @default.
- W3033823508 cites W2010216550 @default.
- W3033823508 cites W2014734784 @default.
- W3033823508 cites W2021306689 @default.
- W3033823508 cites W2026006003 @default.
- W3033823508 cites W2027026672 @default.
- W3033823508 cites W2030955289 @default.
- W3033823508 cites W2042434632 @default.
- W3033823508 cites W2042458697 @default.
- W3033823508 cites W2053950354 @default.
- W3033823508 cites W2054825958 @default.
- W3033823508 cites W2057568081 @default.
- W3033823508 cites W2061575722 @default.
- W3033823508 cites W2066295801 @default.
- W3033823508 cites W2073672902 @default.
- W3033823508 cites W2077495330 @default.
- W3033823508 cites W2080283023 @default.
- W3033823508 cites W2080902075 @default.
- W3033823508 cites W2085516131 @default.
- W3033823508 cites W2086749449 @default.
- W3033823508 cites W2097107919 @default.
- W3033823508 cites W2102374372 @default.
- W3033823508 cites W2105229101 @default.
- W3033823508 cites W2126854509 @default.
- W3033823508 cites W2129554829 @default.
- W3033823508 cites W2132001915 @default.
- W3033823508 cites W2134987297 @default.
- W3033823508 cites W2135057795 @default.
- W3033823508 cites W2135634073 @default.
- W3033823508 cites W2137856266 @default.
- W3033823508 cites W2141721280 @default.
- W3033823508 cites W2161840984 @default.
- W3033823508 cites W2165520535 @default.
- W3033823508 cites W2298739530 @default.
- W3033823508 cites W2311203695 @default.
- W3033823508 cites W2401404581 @default.
- W3033823508 cites W2460873539 @default.
- W3033823508 cites W2475445983 @default.
- W3033823508 cites W2494628338 @default.
- W3033823508 cites W2535017472 @default.
- W3033823508 cites W2751946531 @default.
- W3033823508 cites W2769473564 @default.
- W3033823508 cites W2790257467 @default.
- W3033823508 cites W2807082050 @default.
- W3033823508 cites W2884468388 @default.
- W3033823508 cites W2900444323 @default.
- W3033823508 cites W2948986002 @default.
- W3033823508 cites W2950136933 @default.
- W3033823508 cites W2952178453 @default.
- W3033823508 cites W2963276645 @default.
- W3033823508 cites W2973520306 @default.
- W3033823508 cites W2990322439 @default.
- W3033823508 cites W4249788213 @default.
- W3033823508 doi "https://doi.org/10.3390/md18060298" @default.
- W3033823508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7345734" @default.
- W3033823508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32498449" @default.
- W3033823508 hasPublicationYear "2020" @default.
- W3033823508 type Work @default.
- W3033823508 sameAs 3033823508 @default.
- W3033823508 citedByCount "14" @default.
- W3033823508 countsByYear W30338235082021 @default.
- W3033823508 countsByYear W30338235082022 @default.
- W3033823508 crossrefType "journal-article" @default.
- W3033823508 hasAuthorship W3033823508A5006014190 @default.
- W3033823508 hasAuthorship W3033823508A5012567626 @default.
- W3033823508 hasAuthorship W3033823508A5044888119 @default.
- W3033823508 hasAuthorship W3033823508A5055420267 @default.
- W3033823508 hasAuthorship W3033823508A5055512390 @default.