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- W3033832788 abstract "Ibuprofen is an analgesics-anti-inflammatory agent that is often prescribed, but it has gastrointestinal side effects. Effervescent tablet is expected to resolve that problem, but Ibuprofen has a low solubility in water. So it modified into a solid dispersion using Polyethylene-glycol 6000 as hydrophilic polymer to improved solubility in water. Direct compression method is suitable for solid dispersion, so it needs co-processed excipient. Starches were made by extracting Suweg tuber. Combination of Suweg starch and lactose are developed as co-processed excipient by Simplex Lattice Design method. Ibuprofen-PEG 6000 is formulated with variation of ratio 1:1, 1:1.5, 1:2, 1:3, and 2:1. Optimum ratio was confirmed by yield (%), solubility, drug content, FTIR profile, and SEM. Software Design Expert produce 8 formulas based on lower and upper value of Suweg starch and lactose ratio, with physical responses are hardness, friability and dissolving time. Optimum combination of co-processed excipient was confirmed by statistical analysis of one sample t- test based on physical responses compare to software prediction. Optimum ratio of ibuprofen-PEG 6000 is 1:1. FTIR analysis drug excipient compatibility showed no interaction with polymer and excipients. SEM analysis showed change of particle structure with highest solubility of solid dispersion is 0.37 mg/mL, drug content 99.16%, and yield 96.70%. Optimum proportion of Suweg starch: lactose are 64.32% : 35.68%. Optimum Formula of Effervescent Tablet meets good tablet quality standard and stability, there are : granular flow rate 4.7 6± 0.29 g/sec; angle of response 27.52 ± 0.95 °; dissolving time 211.67 ± 18.88 sec; hardness 2.11 ± 0.05 Kg; friability 0.47 ± 0.04%; pH 6.07 ± 0.02, moisture content 0.41 ± 0.2, and percentage of ibuprofen in tablet 98.54 ± 0.42%." @default.
- W3033832788 created "2020-06-12" @default.
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- W3033832788 date "2020-01-01" @default.
- W3033832788 modified "2023-09-25" @default.
- W3033832788 title "Optimization of Suweg starch (Amorphophallus paeoniifolius (Dennst.) Nicolson) and lactose as co-processed excipient of Ibuprofen-PEG 6000 solid dispersion of effervescent tablet" @default.
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- W3033832788 doi "https://doi.org/10.1063/5.0005632" @default.
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