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- W3033846739 endingPage "553" @default.
- W3033846739 startingPage "531" @default.
- W3033846739 abstract "Abstract The cerebral cortex is divided into areas with different functions in a process called arealization. The areas are further subdivided into vertical columns of excitatory projection neurons (PNs) and inhibitory interneurons (INs) that preferentially intersynapse and simultaneously respond to the same input modality. These elementary functional units of the cortex are called minicolumns. How does the process of neuronal migration contribute to the formation of minicolumns? According to the Radial Unit Hypothesis, minicolumns are composed of sister PNs that arise from a single neural progenitor cell and migrate into the cortical plate through a narrow radial path. This path is kept narrow though a variety of cell–cell interactions and secreted molecules, which constrain the tangential distribution of migrating PNs. The mechanisms that direct migrating INs into particular minicolumns are less clear, but the regulation of the timing and location of a migrating IN's shift from tangential to radial migration is likely to determine which column it enters. A shift from one migration mode to another (radial to tangential or vice versa) is a mechanistically complicated shift, and problems in that shift in both PNs and INs might lead to misfashioned columns and might underlie certain developmental disorders such as autism or schizophrenia." @default.
- W3033846739 created "2020-06-12" @default.
- W3033846739 creator A5036084581 @default.
- W3033846739 date "2020-01-01" @default.
- W3033846739 modified "2023-10-14" @default.
- W3033846739 title "Coordination of different modes of neuronal migration and functional organization of the cerebral cortex" @default.
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