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- W3033852017 abstract "Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in endosomes. On activation, TLR3 initiates a signal transduction pathway that culminates with the secretion of pro-inflammatory cytokines including type I interferon (IFN). The latter is essential not only for innate immune responses to infection but also for the initiation of antigen-specific immunity against viruses and malignant cells. These aspects of TLR3 biology have supported the development of various agonists for use as stand-alone agents or combined with other therapeutic modalities in cancer patients. Here, we review recent preclinical and clinical advances in the development of TLR3 agonists for oncological disorders.Abbreviations cDC, conventional dendritic cell; CMT, cytokine modulating treatment; CRC, colorectal carcinoma; CTL, cytotoxic T lymphocyte; DC, dendritic cell; dsRNA, double-stranded RNA; FLT3LG, fms-related receptor tyrosine kinase 3 ligand; HNSCC, head and neck squamous cell carcinoma; IFN, interferon; IL, interleukin; ISV, in situ vaccine; MUC1, mucin 1, cell surface associated; PD-1, programmed cell death 1; PD-L1, programmed death-ligand 1; polyA:U, polyadenylic:polyuridylic acid; polyI:C, polyriboinosinic:polyribocytidylic acid; TLR, Toll-like receptor" @default.
- W3033852017 created "2020-06-12" @default.
- W3033852017 creator A5030676333 @default.
- W3033852017 creator A5071827163 @default.
- W3033852017 creator A5074612242 @default.
- W3033852017 creator A5075296559 @default.
- W3033852017 creator A5082768888 @default.
- W3033852017 date "2020-01-01" @default.
- W3033852017 modified "2023-10-18" @default.
- W3033852017 title "Trial watch: TLR3 agonists in cancer therapy" @default.
- W3033852017 cites W1483162601 @default.
- W3033852017 cites W1499993276 @default.
- W3033852017 cites W1577872659 @default.
- W3033852017 cites W1588312796 @default.
- W3033852017 cites W1611944043 @default.
- W3033852017 cites W1884940699 @default.
- W3033852017 cites W1911271782 @default.
- W3033852017 cites W1965869838 @default.
- W3033852017 cites W1966042340 @default.
- W3033852017 cites W1969342260 @default.
- W3033852017 cites W1970182669 @default.
- W3033852017 cites W1972285445 @default.
- W3033852017 cites W1975275391 @default.
- W3033852017 cites W1978739865 @default.
- W3033852017 cites W1978942158 @default.
- W3033852017 cites W1979811833 @default.
- W3033852017 cites W1979976650 @default.
- W3033852017 cites W1986283558 @default.
- W3033852017 cites W1992774812 @default.
- W3033852017 cites W1992999021 @default.
- W3033852017 cites W1996922969 @default.
- W3033852017 cites W1999958013 @default.
- W3033852017 cites W2004593104 @default.
- W3033852017 cites W2006406228 @default.
- W3033852017 cites W2006463083 @default.
- W3033852017 cites W2007026865 @default.
- W3033852017 cites W2011702730 @default.
- W3033852017 cites W2011754553 @default.
- W3033852017 cites W2013469022 @default.
- W3033852017 cites W2015415445 @default.
- W3033852017 cites W2016749309 @default.
- W3033852017 cites W2016920052 @default.
- W3033852017 cites W2016959266 @default.
- W3033852017 cites W2023879569 @default.
- W3033852017 cites W2024321861 @default.
- W3033852017 cites W2028331597 @default.
- W3033852017 cites W2029546284 @default.
- W3033852017 cites W2032655351 @default.
- W3033852017 cites W2033023829 @default.
- W3033852017 cites W2034450834 @default.
- W3033852017 cites W2037260140 @default.
- W3033852017 cites W2037580272 @default.
- W3033852017 cites W2040462046 @default.
- W3033852017 cites W2049345643 @default.
- W3033852017 cites W2051414417 @default.
- W3033852017 cites W2052662898 @default.
- W3033852017 cites W2053429123 @default.
- W3033852017 cites W2057130775 @default.
- W3033852017 cites W2057316742 @default.
- W3033852017 cites W2057809738 @default.
- W3033852017 cites W2059066465 @default.
- W3033852017 cites W2059453959 @default.
- W3033852017 cites W2060351820 @default.
- W3033852017 cites W2061275827 @default.
- W3033852017 cites W2062530917 @default.
- W3033852017 cites W2066822302 @default.
- W3033852017 cites W2067632426 @default.
- W3033852017 cites W2067712862 @default.
- W3033852017 cites W2070793039 @default.
- W3033852017 cites W2074120439 @default.
- W3033852017 cites W2076254833 @default.
- W3033852017 cites W2076635765 @default.
- W3033852017 cites W2078764407 @default.
- W3033852017 cites W2079379555 @default.
- W3033852017 cites W2080776017 @default.
- W3033852017 cites W2081796577 @default.
- W3033852017 cites W2083576842 @default.
- W3033852017 cites W2083613729 @default.
- W3033852017 cites W2085234652 @default.
- W3033852017 cites W2087604357 @default.
- W3033852017 cites W2088091610 @default.
- W3033852017 cites W2090994296 @default.
- W3033852017 cites W2092018061 @default.
- W3033852017 cites W2093808311 @default.
- W3033852017 cites W2094490061 @default.
- W3033852017 cites W2095417693 @default.
- W3033852017 cites W2099316577 @default.
- W3033852017 cites W2103112751 @default.
- W3033852017 cites W2108548328 @default.
- W3033852017 cites W2111260918 @default.
- W3033852017 cites W2113492727 @default.
- W3033852017 cites W2115185894 @default.
- W3033852017 cites W2116574496 @default.
- W3033852017 cites W2116760607 @default.
- W3033852017 cites W2120315525 @default.
- W3033852017 cites W2122784347 @default.
- W3033852017 cites W2126004312 @default.
- W3033852017 cites W2126775275 @default.
- W3033852017 cites W2128432936 @default.
- W3033852017 cites W2130421043 @default.