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• W3033854321 abstract "Summary Background Oncostatin M is upregulated in Crohn's disease inflamed intestinal mucosa, and has been suggested as a promising biomarker to predict responsiveness to anti‐TNF therapy in patients with inflammatory bowel diseases. Aim To evaluate the suitability of serum oncostatin M as a predictive marker of response to infliximab in Crohn's disease. Methods We included patients treated with infliximab monotherapy. All patients underwent colonoscopy at week 54 to evaluate mucosal healing. Serum oncostatin M and faecal calprotectin were measured at baseline and after 14 weeks of treatment. Mann‐Whitney test was used to evaluate correlation of oncostatin M and faecal calprotectin at baseline and week 14 with mucosal healing at week 54. Their accuracy in predicting mucosal healing was assessed by area under the curve (AUC). Results In a cohort of 45 included patients, 27 displayed mucosal healing. At both baseline and week 14, oncostatin M levels were significantly lower in patients with mucosal healing than in patients not achieving this endpoint ( P < 0.001). Faecal calprotectin levels at week 14 were lower also in responders than nonresponders ( P < 0.001). Oncostatin M values at baseline and week 14 were significantly associated (Spearman correlation = 0.92, P < 0.001). The diagnostic accuracy of oncostatin M at baseline in predicting mucosal healing (AUC = 0.91) was greater than faecal calprotectin (AUC = 0.51, P < 0.001). Conclusion These results suggest that oncostatin M can predict the outcome of infliximab treatment. Compared with faecal calprotectin, the predictive capability of oncostatin M was appreciable at baseline, thus indicating oncostatin M as a promising biomarker for driving therapeutic choices in Crohn's disease." @default.
• W3033854321 created "2020-06-12" @default.
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• W3033854321 date "2020-06-07" @default.
• W3033854321 modified "2023-10-18" @default.
• W3033854321 title "Serum oncostatin M at baseline predicts mucosal healing in Crohn's disease patients treated with infliximab" @default.
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• W3033854321 doi "https://doi.org/10.1111/apt.15870" @default.
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