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- W3033884071 abstract "Patent ductus arteriosus is associated with multiple comorbidities in premature infants, however a causal link or strategy to decrease these morbidities has not been found. The association between the patent ductus arteriosus and morbidities has biologic plausibility as, like any cardiac mixing lesion, a significant systemic to pulmonic shunt may lead to pulmonary over-circulation and systemic hypoperfusion. Understanding the underlying pathophysiology of associated morbidities in the setting of a patent ductus arteriosus may aid in risk stratifying infants and offer a patient targeted approach to infants with a pathological ductal shunt. While the deleterious impact of increased pulmonary blood flow maybe easier to identify, the impact on end-organ perfusion is more challenging. In this review, we will discuss the pathophysiology of a hemodynamically significant patent ductus arteriosus in premature infants, impact on end-organ perfusion and associated morbidities, and novel modalities to assess shunt volume and effect on end-organ perfusion." @default.
- W3033884071 created "2020-06-12" @default.
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- W3033884071 date "2020-10-01" @default.
- W3033884071 modified "2023-10-18" @default.
- W3033884071 title "Patent ductus arteriosus and cerebral, cardiac, and gut hemodynamics in premature neonates" @default.
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- W3033884071 doi "https://doi.org/10.1016/j.siny.2020.101120" @default.
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