Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033901345> ?p ?o ?g. }
- W3033901345 endingPage "1511" @default.
- W3033901345 startingPage "1503" @default.
- W3033901345 abstract "Abstract Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and clinical remission. However, there is active discussion about the additional advantages of including histological remission as a target. Accumulating evidence indicates that microscopic activity persists in endoscopically quiescent UC, that histological changes may lag behind clinical remission after treatment, and that absence of histological activity predicts lower rates of relapse, hospitalization, surgery and subsequent neoplasia. Obtaining useful information from mucosal biopsies in this setting depends on accurate and consistent evaluation of histological features. However, there is no standardization of biopsy procedures, histological sample processing technique or histological scoring systems, and there is no agreement on the definitions of histological remission, response or activity. Accordingly, a consensus expert panel convened by the European Crohn’s and Colitis Organisation [ECCO] reviewed the literature and agreed a number of position statements regarding harmonization of UC histopathology. The objective was to provide evidence-based guidance for the standardization and harmonization of procedures, definitions and scoring systems for histology in UC, and to reach expert consensus where possible. We propose the absence of intraepithelial neutrophils, erosion and ulceration as a minimum requirement for the definition of histological remission. For randomized control trials we recommend the use of the Robarts histopathology index [RHI] or the Nancy index [NI]. For observational studies or in clinical practice we recommend the use of the NI. To predict the risk of future neoplasia in UC, cumulative histological scores over time are more useful than single scores." @default.
- W3033901345 created "2020-06-12" @default.
- W3033901345 creator A5003632939 @default.
- W3033901345 creator A5010902289 @default.
- W3033901345 creator A5016662642 @default.
- W3033901345 creator A5026242093 @default.
- W3033901345 creator A5029323265 @default.
- W3033901345 creator A5033174333 @default.
- W3033901345 creator A5034073531 @default.
- W3033901345 creator A5042884495 @default.
- W3033901345 creator A5045595770 @default.
- W3033901345 creator A5047563454 @default.
- W3033901345 creator A5050041656 @default.
- W3033901345 creator A5052535018 @default.
- W3033901345 creator A5058227847 @default.
- W3033901345 creator A5058837422 @default.
- W3033901345 creator A5062083052 @default.
- W3033901345 creator A5089243858 @default.
- W3033901345 date "2020-06-06" @default.
- W3033901345 modified "2023-10-18" @default.
- W3033901345 title "ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology" @default.
- W3033901345 cites W1929766967 @default.
- W3033901345 cites W1964102710 @default.
- W3033901345 cites W1964112349 @default.
- W3033901345 cites W1973691341 @default.
- W3033901345 cites W1983254671 @default.
- W3033901345 cites W1985687346 @default.
- W3033901345 cites W1990397098 @default.
- W3033901345 cites W2002483612 @default.
- W3033901345 cites W2007838388 @default.
- W3033901345 cites W2010457821 @default.
- W3033901345 cites W2012281284 @default.
- W3033901345 cites W2015747379 @default.
- W3033901345 cites W2023125040 @default.
- W3033901345 cites W2032892451 @default.
- W3033901345 cites W2034917977 @default.
- W3033901345 cites W2036563054 @default.
- W3033901345 cites W2057618437 @default.
- W3033901345 cites W2058788523 @default.
- W3033901345 cites W2065057455 @default.
- W3033901345 cites W2079332790 @default.
- W3033901345 cites W2087914672 @default.
- W3033901345 cites W2092895549 @default.
- W3033901345 cites W2102649003 @default.
- W3033901345 cites W2103712425 @default.
- W3033901345 cites W2107729707 @default.
- W3033901345 cites W2108599253 @default.
- W3033901345 cites W2110052276 @default.
- W3033901345 cites W2116318925 @default.
- W3033901345 cites W2122443382 @default.
- W3033901345 cites W2128889398 @default.
- W3033901345 cites W2130721872 @default.
- W3033901345 cites W2146687191 @default.
- W3033901345 cites W2149170290 @default.
- W3033901345 cites W2151855380 @default.
- W3033901345 cites W2154052814 @default.
- W3033901345 cites W2166021109 @default.
- W3033901345 cites W2167286837 @default.
- W3033901345 cites W2179998127 @default.
- W3033901345 cites W2284831904 @default.
- W3033901345 cites W2306466871 @default.
- W3033901345 cites W2326968164 @default.
- W3033901345 cites W2333793896 @default.
- W3033901345 cites W2406401379 @default.
- W3033901345 cites W2409292287 @default.
- W3033901345 cites W2472723929 @default.
- W3033901345 cites W2516545869 @default.
- W3033901345 cites W2531437823 @default.
- W3033901345 cites W2543969963 @default.
- W3033901345 cites W2550259131 @default.
- W3033901345 cites W2583633660 @default.
- W3033901345 cites W2589294144 @default.
- W3033901345 cites W2614323529 @default.
- W3033901345 cites W2623019834 @default.
- W3033901345 cites W2737243795 @default.
- W3033901345 cites W2747273870 @default.
- W3033901345 cites W2751232659 @default.
- W3033901345 cites W2753613200 @default.
- W3033901345 cites W2755016301 @default.
- W3033901345 cites W2760887048 @default.
- W3033901345 cites W2763264915 @default.
- W3033901345 cites W2783177521 @default.
- W3033901345 cites W2783221675 @default.
- W3033901345 cites W2787397416 @default.
- W3033901345 cites W2793160664 @default.
- W3033901345 cites W2803416433 @default.
- W3033901345 cites W2884078938 @default.
- W3033901345 cites W2888572800 @default.
- W3033901345 cites W2896640019 @default.
- W3033901345 cites W2901078969 @default.
- W3033901345 cites W2911317352 @default.
- W3033901345 cites W2929751835 @default.
- W3033901345 cites W2938788352 @default.
- W3033901345 cites W2944534759 @default.
- W3033901345 cites W2950290187 @default.
- W3033901345 cites W2971377136 @default.
- W3033901345 cites W2985172642 @default.
- W3033901345 cites W2993154661 @default.