FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3033919932> ?p ?o ?g. }

• W3033919932 abstract "Abstract Background Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreatic ductal adenocarcinoma (PDAC) remains unclear. Herein, we seek to investigate this possibility by a propensity score matching (PSM) analysis. Methods This was a retrospective cohort study in which 419 patients diagnosed with unresectable PDAC and receiving chemotherapy were recruited. Patients were stratified based on the cutoff value of AAPR. The PSM analysis was performed to identify 156 well-balanced patients in each group for overall survival (OS) comparison and subgroup analysis. Univariate and multivariate analyses were carried out to examine the potential of AAPR to indicate the prognosis of unresectable PDAC. The prediction performance of conventional model and combined model including AAPR was compared using the Akaike Information Criterion (AIC) and concordance index (C-index). Results We identified an AAPR of 0.4 to be the optimal cutoff for OS prediction. Patients with AAPR≤0.4 had significantly shorter OS compared with patients with AAPR> 0.4 (6.4 versus 9.3 months; P < 0.001). Based on the PSM cohort and entire cohort, multivariate Cox analysis revealed that high pretreatment for AAPR was an independent marker predicting favorable survival in unresectable PDAC (hazard ratio, 0.556; 95% confidence interval, 0.408 to 0.757; P < 0.001). Significant differences in OS were observed in all subgroups except for the group of patients age ≤ 60. Combined prognostic model including AAPR had lower AIC and higher C-index than conventional prognostic model. Conclusions Pretreatment AAPR servers as an independent prognostic indicator for patients with unresectable PDAC. Inclusion of AAPR improved the prediction performance of conventional prognostic model, potentially helping clinicians to identify patients at high risk and guide individualized treatment." @default.
• W3033919932 created "2020-06-12" @default.
• W3033919932 creator A5002138702 @default.
• W3033919932 creator A5032404132 @default.
• W3033919932 creator A5036381984 @default.
• W3033919932 creator A5036662412 @default.
• W3033919932 creator A5040614393 @default.
• W3033919932 creator A5058931227 @default.
• W3033919932 creator A5082787607 @default.
• W3033919932 creator A5089630065 @default.
• W3033919932 date "2020-06-09" @default.
• W3033919932 modified "2023-10-06" @default.
• W3033919932 title "Albumin-to-alkaline phosphatase ratio serves as a prognostic indicator in unresectable pancreatic ductal adenocarcinoma: a propensity score matching analysis" @default.
• W3033919932 cites W1497359241 @default.
• W3033919932 cites W1931508686 @default.
• W3033919932 cites W1965037168 @default.
• W3033919932 cites W1982024468 @default.
• W3033919932 cites W1983937216 @default.
• W3033919932 cites W1995546722 @default.
• W3033919932 cites W2006744187 @default.
• W3033919932 cites W2006957711 @default.
• W3033919932 cites W2041487550 @default.
• W3033919932 cites W2044783056 @default.
• W3033919932 cites W2058815839 @default.
• W3033919932 cites W2059180671 @default.
• W3033919932 cites W2066052326 @default.
• W3033919932 cites W2066523106 @default.
• W3033919932 cites W2100098337 @default.
• W3033919932 cites W2110015442 @default.
• W3033919932 cites W2117692326 @default.
• W3033919932 cites W2120579447 @default.
• W3033919932 cites W2132556072 @default.
• W3033919932 cites W2133650808 @default.
• W3033919932 cites W2136150034 @default.
• W3033919932 cites W2148238475 @default.
• W3033919932 cites W2151253787 @default.
• W3033919932 cites W2152849583 @default.
• W3033919932 cites W2165480504 @default.
• W3033919932 cites W2260062383 @default.
• W3033919932 cites W2272984102 @default.
• W3033919932 cites W2562047649 @default.
• W3033919932 cites W2573152477 @default.
• W3033919932 cites W2594071329 @default.
• W3033919932 cites W2594484779 @default.
• W3033919932 cites W2613196848 @default.
• W3033919932 cites W2747294052 @default.
• W3033919932 cites W2759471592 @default.
• W3033919932 cites W2766919581 @default.
• W3033919932 cites W2782327081 @default.
• W3033919932 cites W2803832675 @default.
• W3033919932 cites W2910957193 @default.
• W3033919932 cites W2911188335 @default.
• W3033919932 cites W2947957787 @default.
• W3033919932 cites W2961750526 @default.
• W3033919932 cites W2964078044 @default.
• W3033919932 cites W2972538962 @default.
• W3033919932 cites W2985483711 @default.
• W3033919932 cites W2989923235 @default.
• W3033919932 cites W4210976084 @default.
• W3033919932 cites W4229719081 @default.
• W3033919932 doi "https://doi.org/10.1186/s12885-020-07023-9" @default.
• W3033919932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7285790" @default.
• W3033919932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32517802" @default.
• W3033919932 hasPublicationYear "2020" @default.
• W3033919932 type Work @default.
• W3033919932 sameAs 3033919932 @default.
• W3033919932 citedByCount "8" @default.
• W3033919932 countsByYear W30339199322021 @default.
• W3033919932 countsByYear W30339199322022 @default.
• W3033919932 countsByYear W30339199322023 @default.
• W3033919932 crossrefType "journal-article" @default.
• W3033919932 hasAuthorship W3033919932A5002138702 @default.
• W3033919932 hasAuthorship W3033919932A5032404132 @default.
• W3033919932 hasAuthorship W3033919932A5036381984 @default.
• W3033919932 hasAuthorship W3033919932A5036662412 @default.
• W3033919932 hasAuthorship W3033919932A5040614393 @default.
• W3033919932 hasAuthorship W3033919932A5058931227 @default.
• W3033919932 hasAuthorship W3033919932A5082787607 @default.
• W3033919932 hasAuthorship W3033919932A5089630065 @default.
• W3033919932 hasBestOaLocation W30339199321 @default.
• W3033919932 hasConcept C121608353 @default.
• W3033919932 hasConcept C126322002 @default.
• W3033919932 hasConcept C143998085 @default.
• W3033919932 hasConcept C17923572 @default.
• W3033919932 hasConcept C207103383 @default.
• W3033919932 hasConcept C2780210213 @default.
• W3033919932 hasConcept C2992026798 @default.
• W3033919932 hasConcept C38180746 @default.
• W3033919932 hasConcept C44249647 @default.
• W3033919932 hasConcept C50382708 @default.
• W3033919932 hasConcept C71924100 @default.
• W3033919932 hasConcept C72563966 @default.
• W3033919932 hasConcept C90924648 @default.
• W3033919932 hasConceptScore W3033919932C121608353 @default.
• W3033919932 hasConceptScore W3033919932C126322002 @default.
• W3033919932 hasConceptScore W3033919932C143998085 @default.
• W3033919932 hasConceptScore W3033919932C17923572 @default.
• W3033919932 hasConceptScore W3033919932C207103383 @default.
• W3033919932 hasConceptScore W3033919932C2780210213 @default.
• W3033919932 hasConceptScore W3033919932C2992026798 @default.

• next